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    Synthesis of Nano Ceramic Powders for Drug Delivery and It’s Release

    , M.Sc. Thesis Sharif University of Technology Shahriari, Rezvan (Author) ; Nemati, Ali (Supervisor) ; Dobakhti, Faramarz (Supervisor)
    Abstract
    In this project, Fe3O4 nanoparticles were synthesized and coated with different polymeric materials for drug delivery application. For this purpose, water dispersible oleic acid(OA)- pluronic block copolymer coated magnetite iron oxide nanoparticles were synthesized that can be loaded with proper doses of cephalexin. Our data indicated that formulation of iron oxide nanoparticles was developed by optimizing the amount of oleic acid required to coat iron oxide nanoparticles and then by optimizing the amount of pluronic required to form an aqueous dispersion of oleic acid coated nanoparticles. Synthesis of magnetite nanoparticles was done by the addition of a strong base (NH4OH) to ferrous... 

    The Insider Threat: Analyzing and Modeling

    , M.Sc. Thesis Sharif University of Technology Amin, Assiabi (Author) ; Hendesi, Faramarz (Supervisor)
    Abstract
    Nowadays, most of businesses are becoming computer-based. This trend causes the organizations to become more vulnerable to internal and external threats. Internal threats are done through insiders. Insiders unlike outsiders have capabilities which aid them to easily carry out their illicit activities. Unfortunately, most of research in computer security has focused on the outsider threats, whereas the most damaging is the result of insiders’ illicit activities.This dissertation addresses three primary necessities of the research in the area of insider threat: a consistent definition of insider threat, a classification of types of insider threats, and a classification of vulnerabilities which... 

    An Intelligent Routing Protocol for Delay Tolerant Networks Using Genetic Algorithm

    , M.Sc. Thesis Sharif University of Technology Akhavan Bitaghsir, Saeed (Author) ; Hendessi, Faramarz (Supervisor)
    Abstract
    Due to the dynamic topology of vehicular ad hoc networks, routing of packets in these networks faces a lot of difficulties. The situation will become more challenging when we have to deal with Delay Tolerant Networks (DTN) which are also sparse and partitioned and we need to use some vehicles to store the packets and carry them from one partition to another. Despite all these difficulties, by looking through movements of vehicles in an urban environment, we can find out that the topology of the network does not change in a pure random way and we can bring the traffic models of streets into account for having better routing performance. In this thesis, we proposed an intelligent routing... 

    Fire Probabilistic Safety Assessment (Fire-PSA)Level 1 in Auxiliary Building ofIR-360 Nuclear Power Plant

    , M.Sc. Thesis Sharif University of Technology Hassanian, Amir (Author) ; Ghofrani , Mohammad Bagher (Supervisor) ; Yousefpour, Faramarz (Supervisor) ; Karimi, Kaveh (Co-Advisor)
    Abstract
    Fire is one of the most important events in nuclear power plants which has a large share of total core damage frequency. For example, the core damage frequency in Bushehr nuclear power plant from fire accidents is 6.1E-6/ year which is equivalent to about 63 percent of core damage frequency from all internal accidents. However, due to the unavoidable presence of flammable materials, e.g. Electrical equipment, cables, gas, flammable liquids, …), it is impossible to prevent fires in these plants . Fire at nuclear power plants may be caused directly or indirectly by one or more initiating events, which the following accidents in turn would threaten the safety of the plant. In this project,... 

    Probabilistic Safety Assessment of IR-360 for Station BlackOut Accident (SBO) and Determination of the Frequency of Occurrence

    , M.Sc. Thesis Sharif University of Technology Moinian, Fatemeh (Author) ; Ghofrani, Mohammad Bagher (Supervisor) ; Yousefpour, Faramarz (Supervisor) ; Karimi, Kave (Co-Advisor)
    Abstract
    Station Blackout (SBO) involves Loss of Offsite Power (LOOP) concurrent with failure of the onsiteemergency ac power system. Although SBO is a beyond designbasis accident, in recent years this accident attracts a lot of attention. Fukushima nuclear accident which was initiated by earthquake followedby tsunami led to a SBO accident. In this thesis, Probabilistic Safety Assessment (PSA) is applied to analyze SBO in IR-360 nuclear power plant and to compute its frequency. Meanwhile, weak points of the plant are identified in order to minimize the SBOprobability of occurrence. Fault tree method is used to evaluate emergency power system and offsite power system reliabilities. Common Cause... 

    Solvent effects on kinetics of an heteroatomic nucleophilic substitution reaction in ionic liquid and molecular solvents mixtures

    , Article Russian Journal of Physical Chemistry A ; Volume 87, Issue 12 , December , 2013 , pp 1969-1975 ; 1531-863X Salari, H. (Hadi) ; Pedervand, M. (Mohsen) ; Sadeghzadeh-Darabi, F. (Faramarz) ; Gholami, M. R. (Mohammad Reza) ; Sharif University of Technology
    2013
    Abstract
    Rate constants, k A, for the aromatic nucleophilic substitution reaction of 2-chloro-3,5-dinitropyridine with aniline were determined in different compositions of 2-propanol mixed with hexane, benzene, and 2-methylpropan-2-ol and 1-ethyl-3-methylimidazolium ethylsulfate ([Emim][EtSO4]) with dimethyl sulfoxide at 25°C. The obtained rate constants of the reaction in pure solvents are in the following order: 2-methylpropan-2-ol > dimethyl sulfoxide > 2-propanol > hexane > benzene > [Emim][EtSO4]. Molecularmicroscopic solvent parameters corresponding to the selected binary mixtures were utilized to study the kinetics of a nucleophilic substitution reaction in order to investigate and compare the... 

    Kinetic and mechanistic study of p-nitrochlorobenzene photoreduction and Bacillus inactivation over aluminosilicate-based nanocomposites

    , Article Monatshefte für Chemie - Chemical Monthly ; Volume 144, Issue 5 , May , 2013 , pp 589-596 ; ISSN: 1434-4475 Padervand, M. (Mohsen) ; Salari, H. (Hadi) ; Sadeghzadeh Darabi, F. (Faramarz) ; Gholami, M. R. (Mohammad Reza) ; Sharif University of Technology
    2013
    Abstract
    Photocatalytic reduction of p-nitrochlorobenzene was studied over aluminosilicate-based AgBr and AgBr-TiO2 photocatalysts which were prepared and characterized. The photoreaction was performed in the presence of LiBH4, which is a strong reducing agent, in the solution medium. A new mechanism is proposed for reduction of p-nitrochlorobenzene under photocatalytic conditions. The effect of pH, illumination source, LiBH4 concentration, temperature, catalyst dosage, and alcoholic scavengers was also studied. The results showed that the best efficiency was obtained over Ag/AgBr/TiO2/aluminosilicates at natural pH under UV light. We observed that the reaction yield was affected by changing the... 

    A hydrogen-bonded extracellular matrix-mimicking bactericidal hydrogel with radical scavenging and hemostatic function for ph-responsive wound healing acceleration

    , Article Advanced Healthcare Materials ; 2020 Ahmadian, Z ; Correia, A ; Hasany, M ; Figueiredo, P ; Dobakhti, F ; Eskandari, M. R ; Hosseini, H ; Abiri, R ; Khorshid, S ; Hirvonen, J ; Santos, H. A ; Shahbazi, M. A ; Sharif University of Technology
    Wiley-VCH Verlag  2020
    Abstract
    Generation of reactive oxygen species, delayed blood clotting, prolonged inflammation, bacterial infection, and slow cell proliferation are the main challenges of effective wound repair. Herein, a multifunctional extracellular matrix-mimicking hydrogel is fabricated through abundant hydrogen bonding among the functional groups of gelatin and tannic acid (TA) as a green chemistry approach. The hydrogel shows adjustable physicochemical properties by altering the concentration of TA and it represents high safety features both in vitro and in vivo on fibroblasts, red blood cells, and mice organs. In addition to the merit of facile encapsulation of cell proliferation-inducing hydrophilic drugs,... 

    A hydrogen-bonded extracellular matrix-mimicking bactericidal hydrogel with radical scavenging and hemostatic function for ph-responsive wound healing acceleration

    , Article Advanced Healthcare Materials ; Volume 10, Issue 3 , 2021 ; 21922640 (ISSN) Ahmadian, Z ; Correia, A ; Hasany, M ; Figueiredo, P ; Dobakhti, F ; Eskandari, M. R ; Hosseini, S.H ; Abiri, R ; Khorshid, S ; Hirvonen, J ; Santos, H. A ; Shahbazi, M. A ; Sharif University of Technology
    Wiley-VCH Verlag  2021
    Abstract
    Generation of reactive oxygen species, delayed blood clotting, prolonged inflammation, bacterial infection, and slow cell proliferation are the main challenges of effective wound repair. Herein, a multifunctional extracellular matrix-mimicking hydrogel is fabricated through abundant hydrogen bonding among the functional groups of gelatin and tannic acid (TA) as a green chemistry approach. The hydrogel shows adjustable physicochemical properties by altering the concentration of TA and it represents high safety features both in vitro and in vivo on fibroblasts, red blood cells, and mice organs. In addition to the merit of facile encapsulation of cell proliferation-inducing hydrophilic drugs,... 

    A hydrogen-bonded extracellular matrix-mimicking bactericidal hydrogel with radical scavenging and hemostatic function for ph-responsive wound healing acceleration

    , Article Advanced Healthcare Materials ; Volume 10, Issue 3 , 2021 ; 21922640 (ISSN) Ahmadian, Z ; Correia, A ; Hasany, M ; Figueiredo, P ; Dobakhti, F ; Eskandari, M. R ; Hosseini, S. H ; Abiri, R ; Khorshid, S ; Hirvonen, J ; Santos, H. A ; Shahbazi, M. A ; Sharif University of Technology
    Wiley-VCH Verlag  2021
    Abstract
    Generation of reactive oxygen species, delayed blood clotting, prolonged inflammation, bacterial infection, and slow cell proliferation are the main challenges of effective wound repair. Herein, a multifunctional extracellular matrix-mimicking hydrogel is fabricated through abundant hydrogen bonding among the functional groups of gelatin and tannic acid (TA) as a green chemistry approach. The hydrogel shows adjustable physicochemical properties by altering the concentration of TA and it represents high safety features both in vitro and in vivo on fibroblasts, red blood cells, and mice organs. In addition to the merit of facile encapsulation of cell proliferation-inducing hydrophilic drugs,...