Sharif Digital Repository

The respiratory system is a vital organ system which makes breathing and gas exchange possible for human's body. The loss of functionality in this system is due to either genetical problems or environmental issues like pollution or toxic gases which in many cases is inevitable. These circumstances may cause different respiratory diseases which may not be curable presently but their side effects can be partly controlled by careful and timely analysis improving the quality of patient's life. So, an appropriate device for conducting different analysis can be effective for people who suffer from respiratory diseases such as chronic obstructive pulmonary disease (COPD), asthma, occupational lung... 

In this study, a hybrid magnetic-DNA directed immobilisation approach is presented to enhance protein capture and detection on a microfluidic platform. DNA-modified magnetic nanoparticles are added in a solution to capture fluorescently labelled immunocomplexes to be detected optically. A magnetic set-up composed of cubic permanent magnets and a microchannel was designed and implemented based on finite element analysis results to efficiently concentrate the nanoparticles only over a defined area of the microchannel as the sensing zone. This in turn, led to the fluorescence emission localisation and the searching area reduction. Also, compared to processes in which the immunocomplex is formed... 

Over-the-air (OTA) software download is a key enabling technology for terminal reconfigurations. With increasing the number of network protocols, variety of software products with different software providers and new software threats, it becomes important to download and install assured software on the mobile terminals. Most of the related research works on downloading assured software, focus on software validation after download, and mainly on the terminal. In this paper, a model is proposed in which an Assurance Agency is exploited. This agency is responsible for performing software examination and validations. Unlike related work, examination and validation operations are centrally... 

A general modeling framework is presented for the development of the frequency equation of a microgyroscope, which is modeled as a suspended cantilever beam with a tip mass under general base excitation. Specifically, the beam is considered to vibrate in all the three directions, while subjected to a base rotational motion around its longitudinal direction. This is a common configuration utilized in many vibrating beam gyroscopes and well drilling systems. The governing equations are derived by using the Extended Hamilton's Principle with a general 6-dof base motion. The natural frequency equation is then extracted in a closed-form for the case where the beam support undergoes longitudinal... 

This paper discusses the effects of substrate motions on the performance of microgyroscopes modeled as ring structures. Using the Extended Hamiltonian Principle, the equations of motion of a ring micro-gyroscope are derived, and the natural frequency equation and response characteristics are extracted in closed form for the case where the substrate undergoes normal rotation. The Galerkin approximation is then used to arrive at the ordinary differential equations of motion for the ring. In these equations, the effects of angular, centripetal and Coriolis accelerations are all apparent. The response of the system to different inputs is studied and the system sensitivity to variation in input... 

This paper discusses the effects of substrate motions on the performance of a microgyroscope modeled as a ring structure. Using Extended Hamilton's Principle, the equations of motion are derived. The natural frequency equation and response of gyroscope are then extracted in closed-form for the case where substrate undergoes normal rotation. The Galerkin approximation is used for discretizing the partial differential equations of motion into ordinary differential equations. In these equations, the effects of angular accelerations, centripetal and coriolis accelerations are well apparent. The response of the system to different inputs is studied and the system sensitivity to input parameter... 

This paper discusses the effects of substrate motions on the performance of microgyroscopes modeled as suspended beams with a tip mass. The substrate movements can be motions along as well as rotations around the three axes. Using Extended Hamiltonian Principle and Galerkin approximation, the equations of the motion of the beam are analytically derived. In these equations, the effects of beam distributed mass, tip mass, angular accelerations, centripetal and coriolis accelerations are clearly apparent. The effect of electrostatic forces inducing the excitation vibrations are considered as linear functions of beam displacement. The response of the system to different inputs is studied and the... 

This paper presents the modeling steps towards development of frequency equations for a cantilever beam with a tip mass under general base excitations. More specifically, the beam is considered to vibrate in all the three directions, while subjected to a base rotational motion around its longitudinal direction. This is a common configuration utilized in many vibrating beam gyroscopes and well drilling systems. The governing equations are derived using Extended Hamilton's Principle with general 6-DOF base motion. The natural frequency equations are then extracted in closed-form for the case where the base undergoes longitudinal rotation. For validation purposes, the resulting natural... 

Using the public network for distributed computations compromises the immunity of control loops to cyberattacks such as data manipulation and eavesdropping. These risks have forced control system engineers to find solutions to protect control systems against these dangers. Encrypted control studies these dangers and tries to propose new modified control systems to increase the immunity of the control systems. Secret sharing is one of the tools used in the encrypted control field. In this paper, we modify this tool to propose an algorithm to design a secure control system. This scheme while guarantees the security of the control systems, can attenuate the measurement noise as well. To achieve... 

In this article, an easy and low-cost fabrication method for microfluidic chips with 3D electrodes is proposed. As an application of this method, the fabricated chip has been employed as a particle separator using the dielectrophoresis force. This new design does not require a sheath current, and the separation can be done only by using an injection pump, which reduces cost and complexity. The developed microfluidic channel and electrodes are engraved simultaneously using a laser, and therefore the depth of the channel and the electrodes are equal, which increases the efficiency of the chip. Then the electrodes' engraved regions were filled up by silver paste to the level of that of the... 

The present study is aimed at the development of a novel approach based on the magnetic improvement of DNA-directed antibody immobilization to prepare a highly efficient sensing platform. Magnetic nanoparticle substrates with high surface area capture the dual DNA-conjugated antibodies in a solution. This allows overcoming the typical mass transport limitation of the surface-based antibody immobilization. Antibody-magnetic nanoparticle conjugation is based on a robust hybridization between a DNA tether (attached to the antibody) and its complementary sequence (immobilized on the nanoparticle). Conventional antibody immobilization for the detection of proteins is often insignificant for the... 

To increase the flight endurance of a Micro air vehicle (MAVs), which operates at low Reynolds number flow, one way is to harvest energy during its flight. By inspiring from the nature when all the birds use their feathers to control and distribute their power along the flying time, a solution might be design of a piezoelectric plate as feathers, which scavenges energy directly from the fluid flow. Cantilevered beam with piezo-ceramic layer undergoing vortex-induced vibrations can convert the mechanical energy available from the ambient environment to a usable electrical power. Since a flow-driven piezoelectric composite beam takes a form of natural three-way coupling of the turbulent fluid... 

Achievement of industries in production and offering products depends on different factors like having an appropriate maintenance system. This issue should be reached through the most appropriate and practical methods. In this study, based on how the external parameters would influence the productivity of a maintenance system the researcher aims at designing a dynamic system model to analyze the productivity of a maintenance system using acquired information from a car device company by determination of the percentage of parameters and indexes and their influence on maintenance system productivity. The proposed model is simulated for a system with parameters of precise value according to... 

Protein mass spectra pattern recognition is a new forum in which many machine learning algorithms have been conducted to enhance the chance of early cancer diagnosis. The high-dimensionality-small-sample (HDSS) problem of cancer proteomic datasets still requires more sophisticated approaches to improve the classification accuracy. In this study we present a simple ensemble strategy based on measuring the generalizing capability of different subsets of training data and apply it in making final decision. Using a limited number of biomarkers along with 5 classification algorithms, the proposed method achieved a promising performance over a well-known prostate cancer mass spectroscopy dataset.... 

Phytochemical investigation of the aerial parts of Salvia eremophila led to the isolation of a lupane triterpenoid, 3β, 20-dihydroxylupane-28-oic acid (1), together with eight other compounds, comprising three diterpene, two triterpene, two flavonoids and a steroidal glucoside. Their structures were elucidated by interpretation of their one-dimensional and two-dimensional NMR spectra and completed by the analysis of the HRESIMS data. Compounds 1, 2-4 and 8 were evaluated for their cytotoxicities against five human tumour cell lines. Compounds 1 and 3 hold a good potential for use in future studies due to their anti-cancer properties  

The present study is aimed at the synthesis of MnFe2O4@SiO2@PMIDA in terms of highly efficient sensing platform for anti-prostate specific membrane antigen (PSMA) immobilization. Superparamagnetic manganese ferrite nanoparticles were synthesized following co-precipitation method and then SiO2 shell was coated on the magnetic core with tetraethyl orthosilicate (TEOS) through a silanization reaction to prevent oxidation, agglomeration and, increase the density of OH groups on the surface of MnFe2O4. Subsequently, MnFe2O4@SiO2@PMIDA obtained as a result of the reaction between N-(phosphonomethyl)iminodiacetic acid (PMIDA) and MnFe2O4@SiO2. The reactive carboxyl groups on the surface of magnetic... 

Various EEG features have been used in depth of anesthesia (DOA) studies. The objective of this study was to And the excellent features or combination of them than can discriminate between different anesthesia states. Conducting a clinical study on 22 patients we could define 4 distinct anesthetic states: awake, moderate, general anesthesia, and isoelectric. We examined features that have been used in earlier studies using single-channel EEG signal processing method. The maximum accuracy (99.02%) achieved using approximate entropy as the feature. Some other features could well discriminate a particular state of anesthesia. We could completely classify the patterns by means of 3 features and... 

In spite of the extensive literature on the analysis of the muscle synergies during gait, the functionality of these synergies has not been studied in detail. This study explored the relationship between the motor modules and the kinematic maneuvers involved in human walking. Motion and surface electromyography data (of 28 trunk and lower extremity muscles) were acquired from ten healthy subjects during ten trials of self-selected speed gait each. The joint angle trajectories were half-wave rectified and divided into two independent positive directional degrees-of-freedom. The muscle and kinematic synergies were both extracted using the non-negative matrix factorization (NNMF) technique and... 

Streaming potential measurement is one of the electrokinetic techniques used to determine the average zeta potential of porous rock which can provide reliable information on reservoir flow behavior and wettability state of the rock surface. Streaming potential measurement using electrodes has recently been introduced in the oil reservoirs applications and there are still significant uncertainties during the measurements and interpretation of streaming potential results. The primary purpose of this work is to establish a setup to measure the streaming potential of porous media with low scattering and evaluate voltage measurements based on the paired stabilization and pressure ramping methods.... 

The effects of severe shot-peening process and formation of a nanostructured surface layer on mechanical properties of A356.0 alloy were investigated in this paper. X-ray diffraction analyses revealed that the average size of near-surface grains in severe shot-peened specimens is 75.8 nm. Three types of disk-shaped specimens, non-treated, conventionally shot-peened, and severely shot-peened were subjected to pin-on-disk wear test in the dry condition, in different loading and sliding speeds. Shot-peening process increases both hardness and roughness of the surface, and these two factors have, respectively, positive and negative effects on wear resistance. However, because of high-density...