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    Mesoporous silica nanoparticles (MCM-41) coated PEGylated chitosan as a pH-Responsive nanocarrier for triggered release of erythromycin [electronic resource]

    , Article International Journal of Polymeric Materials and Polymeric Biomaterials ; 2014, Volume 63, Issue 13, Pages 692-697 Pourjavadi, A. (Ali) ; Mazaheri Tehrani, Zahra ; Sharif University of Technology
    Abstract
    A pH-responsive drug delivery system based on core shell structure of mesoporous silica nanoparticle (MSN) and chitosan-PEG copolymer was prepared and characterized by Fourier transform infrared spectroscopy (FT-IR), thermogravimetric analysis (TGA), scanning electron microscope (SEM), and high-resolution transmission microscope (HR-TEM) techniques. In order to improve compatibility MSN and drug, mesoporous nanosilica was modified by 3-aminopropyl triethoxysilane. The release of erythromycin (a macrolide antibiotic) as a model drug was investigated in two pHs, 7.4 and 5.5  

    Theoretical and Computational Investigation of Quantum Plasmonic Properties of Nanocluster Dimers

    , M.Sc. Thesis Sharif University of Technology Mahmoudi, Erfan (Author) ; Jamshidi, Zahra (Supervisor)
    Abstract
    In today's era, metal nanoparticles play an important role in technologies emerging from different sciences, such as chemistry, physics, optics, material science, due to their unique characteristics. In the development of nanooptics science, it can be said that metal nanoparticles play an important role. The ability of conductive electrons collective oscillation causes surface charge density fluctuations in nanoparticles, this phenomenon is known as surface plasmons. Surface plasmons are surprisingly coupled with light and cause the significant increase in the intensity of optical fields induced in nanoparticles. Therefore, with the presence of localized surface plasmons or plasmon... 

    Theoretical Investigation of Ab-initio MD Approach to Increase the Efficiency and Accuracy of VCD Spectrum Calculation

    , M.Sc. Thesis Sharif University of Technology Hadi, Hossein (Author) ; Jamshidi, Zahra (Supervisor)
    Abstract
    Understanding of the Molecules is the main purpose of the chemistry. Ab-initio molecular dynamics (AIMD) as a branch of the computational chemistry, tries to give us a deep comprehension of the molecule, and its chemical, physical and optical activities. This comprehension, relies on the accuracy of quantum mechanics, in addition to the speed of the classical mechanics. The mixing of the quantum mechanics and the classical mechanics could simulate activities of the atoms in the time-domain, provided the mixing is done with precaution. This, in turn, helps us to forecast the response of a molecule in different situations, and also translating the macroscopic phenomena in a nanoscopic... 

    Investigation of Plasmonic Excitation in Carbonic Nanostructures Within Near-IR

    , M.Sc. Thesis Sharif University of Technology Madadi, Mahkam (Author) ; Jamshidi, Zahra (Supervisor)
    Abstract
    To date, the plasmonic properties of many metallic and semi-conducting materials have been investigated and used in various industries. One of the plasmonic material categories that have always been considered is polycyclic aromatic hydrocarbon or PAH, whose plasmonic resonance energy depends on the charge state of the molecule. In this regard, it is easy to change the plasmonic resonance energy via changing the induced charge, which is a unique feature of the mentioned materials. In addition, plasmonic structures with excitations in the infrared region are able to enhance the vibration intensity of absorbed molecules by increasing the electric field around themselves. Therefore, they have... 

    Using Nonlinear Effects of Light for Optical Signal Processing

    , M.Sc. Thesis Sharif University of Technology Shatery, Farshid (Author) ; Kavehvash, Zahra (Supervisor)
    Abstract
    Ultrafast signal processing in time-domain with high resolution and reconfigura-bility is a challenging task. This paper, for the first time, introduces a time-varying metasurface consisting of graphene microribbon array for implementing time-lens in the terahertz domain. Given that the surface conductivity of graphene is proportional to the Fermi energy level in the THz regime, it is possible to change the phase property of the incident electromagnetic pulse by changing the Fermi level while the Fermi level itself is a function of voltage. Upon this fact, a quadratic temporal phase modulator, namely time-lens has been realized. This phase modulation is applied to the impinging signal in the... 

    Using Simulation-Optimization Approach for Fire Station Location and Vehicle Assignment Problem: a Case Study in Tehran, Iran

    , M.Sc. Thesis Sharif University of Technology Pirmohammadi, Ali (Author) ; Amini, Zahra (Supervisor)
    Abstract
    In this research, the problem of locating fire stations and allocating equipment has been studied and a simulation-optimization approach has been presented to solve the problem. The mathematical models of this research were developed based on the idea of the randomness of the covered demand and the maximum expected coverage model. In these models, the issue of non-availability of equipment to cover accidents, the random nature of accidents, various fire incidents and the equipment needed to cover them are considered. Two mathematical models with deterministic and non-deterministic approach with different scenarios for demand are proposed. The non-deterministic model is developed with the aim... 

    Introducing An Integrated Framework For Solving The Fleet Planning Problem Using A Simulation-Optimization Approach

    , M.Sc. Thesis Sharif University of Technology Sahebi, Armin (Author) ; Amini, Zahra (Supervisor)
    Abstract
    One of the main concerns of industrial companies’ managers is providing an efficient logistics system. To achieve an efficient logistics system, the fleet planning problem is studied by many researchers in recent years. This problem consists of multiple sub-problems at three levels: operational, tactical, and strategic. These sub-problems are closely related to each other and need to be studied and addressed in an integrated manner. In this research, an attempt is made to provide an integrated framework to solve the vehicle routing problem (operational), outsourcing problem (tactical), and fleet composition problem (strategic). These problems have various uncertainties, including customer... 

    Analytical Modelling and Optimization of Disk Type, Slot Less Resolver

    , M.Sc. Thesis Sharif University of Technology Moheyseni, Atefeh (Author) ; Nasiri Gheidari, Zahra (Supervisor)
    Abstract
    Resolvers, due to their robust structure, are widely used in automation systems. Among the types of resolvers, the accuracy of the Wound Rotor (WR) resolver in the occurrence of common mechanical errors is higher than other types of resolvers. therefore, in this thesis, an AFWRR is studied to improve the performance. Increasing the number of poles in WR resolvers is a good solution for increasing the accuracy of these electromagnetic position sensors. However, high-speed WR resolvers due to employing fractional slot windings suffer from rich sub-harmonics in the induced voltages. A common solution for suppressing the undesirable sub-harmonics is using multi-layer winding with appropriate... 

    A Survey on Searchable Symmetric Encryption Schemes

    , M.Sc. Thesis Sharif University of Technology Sajadieh, Zahra Sadat (Author) ; Khazaei, Shahram (Supervisor)
    Abstract
    Using “Searchable Encryption” enables us to encrypt the data, while preserving the possibility of running search queries. One of the most important applications of the mentioned is in Cloud Storage. As users do not trust the Cloud space, they are not inclined to store their data on the Could. The solution to this problem is of course, Cryptography. However, ordinary Cryptography methods, eliminate the data’s searchability. Hence, we need encryption schemes that code the data while retaining their searchability. So far, various schemes has been proposed that differ in their performance, security level, and usage. In this thesis, we aim to discuss and analyze these methods  

    Time Domain Optical Signal Processing Based on the Duality Between Dispersion and Diffraction

    , M.Sc. Thesis Sharif University of Technology Eksiri, Fatemeh (Author) ; Kavehvash, Zahra (Supervisor)
    Abstract
    In the last decades, due to the growing demand of transferring information with high transmission rates, the complexity and development of telecommunication and optical systems is remarkable. Researchers around the world attempt to explore extraordinary potential of light to process information. In the mid-19th century, scientists discovered a mathematical symmetry between the spatial and temporal optics fields, which originated from the similarity of equations governing the paraxial diffraction of beams and the dispersion of narrow-band pulses known as space– time duality in scientific texts. This new approach provides more advanced and potent methods to temporal processing and... 

    Improving the Stability of an Urban Traffic Network with Limited Data by Using Percolation Theory and Dynamic Clustering

    , M.Sc. Thesis Sharif University of Technology Hassanzadeh, Ehsan (Author) ; Amini, Zahra (Supervisor)
    Abstract
    One of the most vital aspects of understanding the traffic phenomenon is scrutinizing the traffic transition status, such as the transition from free flow to congestion. The Percolation Theory is a renowned theory focusing on analyzing various network types to detect the critical zones, which are the zones including links that are important to control to improve stability. By calculating the quality indices of network links, the Percolation Theory can simulate the traffic percolation propagation in the network and determine possible critical zones for further analysis. Most studies in this field assume access to data of several traffic parameters for the entire transportation network, such... 

    Temporal Depth Imaging Based on Dispersion

    , M.Sc. Thesis Sharif University of Technology Behzadfar, Shiva (Author) ; Kavehvash, Zahra (Supervisor)
    Abstract
    In this thesis, the aim is designing an optical temporal imaging system. In recent years, due to many applications, including the receipt of high-rate data by slow receivers and compensation of dispersion in telecommunication systems, researchers have considered the topic of temporal imaging. This field of research is based on dispersion, electro-optical modulators or time lenses and space-time theory. By modeling dispersion properties as a depth dimension and taking ideas from three-dimensional spatial imaging systems we intended to increase the temporal resolution and depth of focus of the structure. We also present a novel technique for multiplexing and demultiplexing telecommunication... 

    Traffic Flow Imputation for Urban Roads with Graph Neural Networks

    , M.Sc. Thesis Sharif University of Technology Sabzekar, Sina (Author) ; Amini, Zahra (Supervisor)
    Abstract
    Traffic data plays an essential role in Intelligent Transportation Systems (ITS) and offers numerous advantages, including efficient traffic control and system performance improvement. However, due to the scarcity of data collection systems, missing data in traffic datasets is inevitable. Therefore, traffic data imputation becomes an essential task. Graph Neural Network (GNN) is a type of neural network that operates on graph-structured data and has shown potential in handling traffic network related tasks such as traffic prediction and traffic data imputation. In this paper, we contribute to the body of knowledge with two aspects. First, we focus on traffic data imputation using solely... 

    Modification of Biomedical Imaging Methods in Short Wavelength Infrared Window

    , Ph.D. Dissertation Sharif University of Technology Hassan Abbasi (Author) ; Kavehvash, Zahra (Supervisor)
    Abstract
    In recent years, optical biomedical imaging techniques show great potential in noninvasive imaging. Although these methods have many advantages over other biomedical imaging methods (such as Computerized Tomography (CT), Magnetic Resonance Imaging (MRI) and etc.), these techniques confront with some problems such as optical scattering, light absorption and etc. For in vivo imaging, the short-wavelength infrared region (SWIR; 1,000–2,000 nm) provides several advantages over the visible and near-infrared regions: general lack of auto-fluorescence, low light absorption by blood and tissue, and reduced scattering. In this thesis we want to analyze the traditional IR imaging techniques and... 

    Upgrading the Ultrasound Imaging System Based on The Implementation of the Strain Imaging Mode

    , M.Sc. Thesis Sharif University of Technology Fathi, Haniyeh (Author) ; Kavehvash, Zahra (Supervisor)
    Abstract
    Strain imaging is a non-invasive ultrasound modality for assessing cardiac function in echocardiography systems. In this thesis, we implemented a fully automated strain imaging system containing 5 steps: 1) echocardiographic view recognition, 2) cardiac cycle phase detection, i.e., the events of end-diastole (ED) and end-systole (ES), 3) segmentation of left ventricular (LV) myocardium, 4) motion estimation of this wall and 5) strain calculation. In this work, we propose a novel deep learning-based framework for phase detection of cardiac cycle by the use of echocardiographic images in multibeat videos. Further, by applying the augmentation technique, the model has been able to detect events... 

    Design, Analysis, Fabrication and Experimental Study of a Large Organs Laparoscopic Surgery Instrument with Tactile Sensing

    , Ph.D. Dissertation Sharif University of Technology Mirbagheri, Alireza (Author) ; Farahmand, Farzam (Supervisor)
    Abstract
    In order to perform laparoscopic surgery of large intra-abdominal organs with minimum trauma on patient’s body, an endoscopic tool is designed, analyzed and fabricated in this project. This instrument is capable of passing through a 10mm incision point on patient’s abdomen and then be opened to grasp and hold large organs up to 80mm in diameter. It acts as a miniature hand with three fingers which are opened and closed parallel with each other. Using this tool, there will be no need for a 7-9 cm incision for entering surgeon hand which is required in hand assisted laparoscopic surgery method. In order to evaluate the capability of the tool in grasping and manipulating large organs, the... 

    Robotic Modeling of Paraplegic Locomotion to Improve the Gait Efficiency Using Modified Motion Pattern and Orthotics Design

    , M.Sc. Thesis Sharif University of Technology Abdolshah, Saeed (Author) ; Farahmand, Farzam (Supervisor)
    Abstract
    Walking on legs using orthosis for spinal cord injury patients has many advantages and decreases the physiological and psychological problems comparing with wheelchair application, however high energy consumption and early exhaustion of patients are disadvantages of orthosis usage. The most important group of orthosis for spinal cord injury patients is RGO (Reciprocating Gait Orhtosis) which a reciprocating cable mechanism links two hip joints motion. So swinging of mobile leg gets easier and stability of patient in standing and walking step increases. Regarding to existent reports about high energy consumption in walking by orthosis, this project has been fulfilled to design an improved... 

    Design and Implementation of a Master Robot for a Fracture Reduction Robotic Telesurgery System

    , M.Sc. Thesis Sharif University of Technology Nazari, Kianoosh (Author) ; Farahmand, Farzam (Supervisor)
    Abstract
    Common fracture treatments include open reduction and intramedullary nailing technology. However, these methods have disadvantages such as intraoperative X-ray radiation, delayed union or nonunion and postoperative rotation. Robots provide a novel solution to the aforementioned problems while having new challenges. The robotic system used in the study by providing more precise motion and exerting higher amount of forces makes the operation procedure more straightforward. In a normal operation 300-400 N of extension force would be needed which is fully provided by the surgen which leads to physical his/her (khastegi), by using the robotic system however, this force is simply provided without... 

    Human Arm Modeling in Haptic Training System of Sinus Endoscopy

    , M.Sc. Thesis Sharif University of Technology Esfandiari, Mojtaba (Author) ; Farahmand, Farzam (Supervisor)
    Abstract
    In recent years, computer haptics research area have gradually grown all around the world. It deals with displaying the rendered contact properties in a virtual environment to a human user while interaction to a haptic interface. In general, a haptic interface provides essential haptic feedback information of a remote environment to a human user. The human operator, as a part of computer haptic system, will usually make an interaction by the haptic interface in a real environment which is usually limited to the end-effector of the physical device. On the other hand, the virtual tool in the virtual environment will interact by the virtual based remote environment which is generated from the... 

    Design and Implementation of an Activation Mechanism for Wristed Laparoscopic Instruments at Sina Robotic Surgery System

    , M.Sc. Thesis Sharif University of Technology Hanifeh, Shahrzad (Author) ; Farahmand, Farzam (Supervisor)
    Abstract
    Sina surgical system is a telesurgery robotic system which is capable of using the conventional laparoscopic tools. In order to provide the wrist degree of freedom and increase the surgical maneuverability, a mechanism is introduced here which enables Sina to use and activate the wristed laparoscopic instrument Laparo-Angle. At first, the kinematics and dynamics characteristics of Laparo-Angle were identified experimentally. This tool contains 4 degrees of freedom, pitch, yaw, grasp and distal Roll. Activation of pitch and Yaw degrees of freedom requires a mechanism which at least has two rotational degrees of freedom to move the tool handle in a cone shape workspace with an apex angle of 36...