Sharif Digital Repository

Many efforts have been performed on the poly(vinylidene fluoride), PVDF, due to its piezoelectric, pyroelectric and ferroelectric potentials. In this thesis Poly (vinyldene Flouride) (PVDF)/Poly (vinyl Asetate) (PVAc)/Multi-walled carbon nanotubes (MWCNT) and Poly (vinyldene Flouride) (PVDF)/Poly (vinyl Asetate) (PVAc)/Graphene Oxide nonasheets (GOn) nanocomposite films were prepared via solution casting method. The effect of concentration of PVAc, MWCNT and graphene oxide on PVDF nanocomposites were investigated. Graphene oxides synthesized by modified Hummer’s method. Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) results showed that the crystalline structure of... 

In this work, magnetite (Fe3O4) nanoparticles with an average siz21.9nm
modified by oleic acid were prepared by the coprecipitation method, which can linked well with organic molecules because of the presence of C-O-C on their surface. Then magnetic poly(lactic acid) (PLA)/ poly(ethylene glycol) (PEG) microspheres were prepared by the single emulsion solvent evaporation technology. The incorporation of magnetit nanoparticles and dox into the PLA matrix was confirmed by FTIR. XRD and VSM confirmed the existence of MNPs in the microspheres which maintained superparamagnetic behavior with a saturation magnetization of 50.69 emu/g.Electron microscopy SEM showed that the magnetic microspheres... 

The purpose of this project was to produce and examine the Poly(lactic acid)/poly(ethylene-co-vinyl acetate)/ nano-clay nanocomposite by solution casting that can be used for food packaging. In this study, it was observed that solvent evaporation at 4°C gives uniform films, without phase separation and free of voids, in a certain composition of polymers related to the rate of solvent evaporation.According to DMTA results Poly(lactic acid) and poly(ethylene-co-vinyl acetate) with 28% vinyl acetate, were compatible in less than 10% poly(ethylene-co-vinyl acetate) content in blend of them. Also, results of SEM tests showed that ethylene-co-vinyl acetate particle size in blends with 3 and 5... 

Polyvinylidene fluoride is highly regarded by researchers due to its piezoelectric properties, mechanical properties, chemical and thermal stability and biocompatibility. This thermoplastic polymer has a semi-crystalline structure and, depending on the crystallization conditions, has five distinct crystalline phases α, β, γ, δ and ε. The β, γ and δ phases are electroactive, and among them, the β phase has high piezoelectric activity due to its high dipole moment. This study focuses on increasing the amount of β phase in polyvinylidene fluoride and increasing its piezoelectric property. Polyvinylidene fluoride is highly miscible with oxygen containing polymers such as polymethyl... 

In this research, the EVA/BT/MWCNT nanocomposites were prepared via the solution casting method in the various weight fractions of Barium titanate (BT) and multi-walled carbon nanotubes (MWCNT). Barium titanate-based ceramic material has a high dielectric constant, and it is used in the manufacture of sensors, capacitors, and electrical memories. On the other hand, multi-walled carbon nanotubes, due to electric charges on their surface and high electrical conductivity, can affect the dielectric properties combined with barium titanate and the hybrid of these two materials a polymer matrix suitable for special applications. In this study, ethylene-vinyl acetate (EVA) copolymer was used as a... 

In recent years, the tendency to use biodegradable and biocompatible polymer nanoparticles for drug delivery applications has been increasing, the reason for this being the possibility of precise control of the drug release rate, ease of use, and no need for external Surgery after the release of the drug, increases the therapeutic efficiency of the drug and reduces the side effects with its precise transfer. In this research work, drug carrier nanocomposites were prepared from polylactic acid (PLA), polyethylene glycol (PEG) and hydroxyapatite (HAp) and for the controlled release of ciprofloxacin (CIP). It was used to treat bone infections. The drug loading efficiency for nano-carriers was... 

Composite film PLA/PVDF and nanocomposite films PLA/PVDF/MWCNT with a solution method by solvent Dimethyl formamide was prepared at 65◦c. poly vinylidene fluoride as matrix phase and poly lacticacid was used an amplifier. In the next sextion multiwalled carbon nanotubes were added to the PLA/PVDF composite.Scaning Electron microscope results, showed that the PLA/PVDF composite and PLA/PVDF/MWCNT nanocomposites, non porous structure and carbon nanotubes in the polymer matrix have been well dispersed. The impact of nanoparticles in the polymer matrix by X-Ray Diffraction and Differential Scaning Calorimetry was investigated. With differential scaning calorimeter (DSC) and stress strain test,... 

Polyvinyl alcohol and polyvinyl pyrrolidone polymers are among the biocompatible and widely used polymers that are very important in medical science and their composites are used in tissue engineering, bone engineering, etc. Various nanoparticles have been used to improve the properties of these composites. With this knowledge, in this study, to prepare a biocompatible nanocomposite for medical engineering and improve the piezoelectric, mechanical, and electrical properties of these two polymers, different percentages of these polymers were prepared with barium titanate nanoparticles and scanning electron microscopy using infrared spectroscopy tests. Mechanical properties tests,... 

In this research, we developed a drug release system of two biocompatible and biodegradable polymers and biocompatible ceramic nanoparticles. Hydrogels of sodium alginate (SA) were crosslinked using calcium chloride. The SA hydrogels were blended with polyvinyl pyrrolidone (PVP) and mixed with hydroxyapatite nanoparticles (HAP) to make hydrogel nanocomposites in the form of microbeads as drug carriers. Ciprofloxacin was selected as a model antibiotic drug for treatment of bone infection. It was found that SA and PVP form hydrogen bonds and are miscible at whole range of concentrations. Indeed, the SA/PVP blends may be considered as interpenetrating polymer networks (IPNs). HAP nanoparticles... 

Poly (Lacticacid) belongs to the family of aliphatic polyesters. PLA can be made from annually renewable resources to yield articles for use in either the industrial packaging field or the biocompatible /bioabsorbable medical device market. Production of PLA through polycondensation in an industrial way was the aim of this project. In order to have the appropriate reaction conditions a steel reactor was designed and constructed. Feasibilty of PLA production in the constructed reactor was investigated and the product was analyzed, using H-NMR and FT-IR spectrum analysis. The average molecular weight was measured by GPC and ubbelohde viscometery method. Studies have shown that oligomerization... 

Poly (vinyl alcohol) (PVA) hydrogel is a biocompatible material, which has been widely applied in drug delivery applications. Microspheres, nanospheres, and other types of particle-based drug delivery vehicles have proven capacity for long-term release. There is growing interest to overcoming the inherent pharmacological limitations of hydrogels by formulating particulate systems into the hydrogel matrix to form new delivery platforms. We here describe a simple composite system based on poly (vinyl alcohol) (PVA) hydrogels containing entrapped drug-loaded poly (lactic acid) (PLA) microspheres for controlled delivery over extended period of time. Gamma-Irradiation and freeze-thawing was... 

One of the great challenges of food industry is the lack of packing materials which can disperse active compositions properly for variety of applications; therefore an antioxidant/antibacterial release system of poly lactic acid in a specific time is a necessity for being used in food packing industry. Most of the researches have been done in the field of drug release system, yet numbers of researches done in the field of food industry are rare. Rate of antibacterial/antioxidant release from polymeric film is relatively fast also calculated based on Fick’s second law of diffusion; therefore primary poly lactic acid is modified by adding ameliorative agents such as poly ethylene glycol and... 

Poly vinyl alcohol/graphene oxide (GO) nanocomposites were made through solution casting method. The nanocomposite were characterized by XRD , FTIR , FESEM , DSC and mechanical measurements. Graphene oxide was irradiated by gamma ray at 35 KGy in a 50/50 water-ethanol solution and then added to PVA aqueous solution in various GO concentrations (0.3 , 0.7 , 1 wt%) and sonicated. The resulting suspensions were cast into petri dishes to make thin films. Also PVA/GO Hydrogels were prepared by gamma irradiation at 20 KGy. It was observed that GO uniformly dispersed within PVA indicating strong interaction through forming hydrogen bonds between hydroxyl groups of PVA and GO surface. Tensile... 

Polyvinylalcohol/MWCNT nanocomposite films were fabricated via solution casting method. Glycerol was added to the polymer matrix as plasticizer in order to improve the flexibility and toughness of resultant films. Surface modification of MWCNTs were carried out by subjecting to gamma irradiation of 60Co source to total doses of 50.0 and 75 kGy in pure ethanol and in a solution with equal volume fraction of water and ethanol. The produced nanocomposites in each case which contain different type of modified MWCNTs were characterized by x-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), mechanical and electrical measurements. The... 

The goal of this research project was to prepare gelatin/PVA porous scaffolds by chemical and gamma irradiation methods to be used for human dermal fibroblast cell culture. First, the polymers were dissolved in hot water and mixed properly to achieve a homogenous solution. The mixture was then frozen at -200C and immersed in ethanol/ glutaraldehyde solution at -200C for 48 hours in order to extract ice crystals and also form chemical crosslinks in gelatin by glutaraldehyde. After being rinsed with distilled water the samples were lyophilized. The effects of polymers solution concentration, gelatin/PVA ratio and glutaraldehyde /gelatin ratio were investigated on characteristics of the... 

The nucleus pulposus, which is a part of intervertebral disc, is normally hydrated and gel-like to maintain normal biomechanical functions of the disc through intradiscal pressures. In a degenerated disc, however, water content of nucleus is significantly reduced, resulting in an abnormal stress state of the annulus. Surgical interventions cannot restore the biomedical function to vertebral segment. One approach to restore the normal biomechanics of an intervertebral disc is to replace the nucleus with a prosthetic material which leads to a restoration of the behavior of the disc. The mechanical behavior of poly(vinyl alcohol) and nanodiamond hydrogel may provide a material suitable for... 

Ethylene vinyl acetate copolymer produces flexible products and is compatible with many polymers and additives, the reason is that it has Vinyl group which is polar and Ethylene group which is nonpolar. In fact, it consists of two parts. One is a hard and semi-crystalline Polyethylene region and the other is soft, flexible, polar, and amorphous Vinyl Acetate. Improving the properties of this copolymer can broaden its application. For this purpose, Ethylene Vinyl Acetate with 18 and 28% Vinyl Acetate was used as a matrix and nano-alumina as reinforcement in this project. The spherical structure and chemicallu active surface, along with significant mechanical properties, suggeats Alumina... 

Today, tissue engineering research is expanding to a large extent, so tissue engineering has the ability to build artificial organs and tissues. In this project, we have used two polymers of polyethylene glycol and polyvinyl chloride, which are used for network irradiation. After irradiation, these polymers were made by drying the freewheeling porous scaffolds and the effect of different parameters on the structure of these scaffolds was investigated. To investigate the effect of different factors on gelation, swelling, tensile test, degradability and finally the conditions of fibroplast cell growth on scaffolds were investigated. The results of the gel test showed that the gel was higher... 

In recent years along with time and cost intensive process of developing new and better drugs for diseases like cancer, scientists and researchers are attempting to develop novel drug delivery systems for already existing drugs.The purpose of these novel drug delivery systems such as nanogels is controlling drug release rate as well as delivery to a specific target tissue in order to reduce side effects. One of the most commonly used drugs for cancer treatment is Doxorubicin HCl, commercially known as Adricin. In this project biodegradable and biocompatible polymers PLA and PEG were used to synthesize nanocarriers for Adricin. These nanocarriers were then dispersed in an agar hydrogel. The... 

Nowadays, the use of processed conductive polymers for conducting matrix polymers, as well as improving other properties for planting in the body, is very common. In this project, the fabrication and identification of electrically conductive films and fibers from biocompatible poly lactic acid and conductive polyAniline polymer in the form of nano-fibers or nanoparticles was intended. These fibers and films have been made in form of a plate or tube then, have been used as biosensors. These polymeric prostheses should be sterilized before planting in human body. Gamma rays are the best sterilization methods and are used at low doses (25 kGy) to sterilize plastic medical supplies. On the other...