Sharif Digital Repository

Biodegradable magnesium (Mg) alloys exhibit great potential for use as temporary structures in tissue engineering applications. Such degradable implants require no secondary surgery for their removal. In addition, their comparable mechanical properties with the human bone, together with excellent biocompatibility, make them a suitable candidate for fracture treatments. Nevertheless, some challenges remain. Fast degradation of the Mg-based alloys in physiological environments leads to a loss of the mechanical support that is needed for complete tissue healing and also to the accumulation of hydrogen gas bubbles at the interface of the implant and tissue. Among different methods used to... 

The effects of Sr additions, heat treatment (T4 and T6), and multi-directional forging on the microstructural evolution, mechanical properties and biodegradability of Mg-4Zn-xSr alloys were investigated. Corrosion behavior of the alloys was evaluated by the polarization and hydrogen evolution tests. Shear punch and hardness tests were employed to determine the mechanical properties. It was found that mechanical properties and corrosion resistance of the as-cast Mg-4Zn alloy increased by 0.3 wt% Sr addition. However, further increasing the Sr content not only did not improve the mechanical strength, but also had detrimental effects on the corrosion resistance, due to the increased size and... 

Magnesium and its alloys have gained significant popularity due to their light weight and their potential for use as bioresorbable materials. However, their application is limited in practice due to their relatively poor corrosion resistance. Several methods are available for improving the corrosion resistance of Mg alloys for bio-applications such as using different coatings, alloying, and modifying the microstructural parameters such as the grain size and the crystallographic texture. This review provides a comprehensive summary of the effects of crystallographic texture and twinning, as one of the most important deformation mechanisms of Mg and Mg alloys, on the corrosion behavior.... 

Magnesium and its alloys have gained significant popularity due to their light weight and their potential for use as bioresorbable materials. However, their application is limited in practice due to their relatively poor corrosion resistance. Several methods are available for improving the corrosion resistance of Mg alloys for bio-applications such as using different coatings, alloying, and modifying the microstructural parameters such as the grain size and the crystallographic texture. This review provides a comprehensive summary of the effects of crystallographic texture and twinning, as one of the most important deformation mechanisms of Mg and Mg alloys, on the corrosion behavior.... 

The effects of Sr additions (0.3, 0.6 and 0.9 wt%) on the microstructural evolution, thermal stability, and mechanical properties of a cast Mg–4Zn alloy were investigated. The extent of grain growth and stability of the intermetallic compounds were studied by optical and scanning electron microscopy (SEM), respectively. Mechanical properties of the studied alloys were evaluated by shear punch testing (SPT) method and also the hardness test. Hardness and shear strength of the base alloy were increased by Sr additions in the as-cast condition, due to the grain refinement effect of Sr and also presence of the Sr-containing Mg17Sr2 and Mg70Zn25Sr5 precipitates. However, the optimum amount of Sr... 

Hydrothermal method was applied to create a protective coating on the Mg–4Zn–0.3Sr alloy, using de-ionized water (as precursor) for different synthesizing times of 3, 4, 5, and 6 h. XRD and EDS line-scan confirmed formation of Mg(OH)2 coating. Based on the surface morphological appearance, 5 h coating time at 160 °C was found to be the optimum condition. The corrosion current of 2.58 µA/cm2 in the uncoated sample decreased to 0.48 µA/cm2 in the coated condition. Also, the cytotoxicity assessments using Alamar blue test showed that the cell viability and cell attachment to the formed Mg(OH)2 coating are more pronounced in comparison with the uncoated alloy. © 2022 Elsevier B.V  

In vivo dose-dependent effects of nanoscale graphene oxide (NGO) sheets on reproduction capability of Balb/C mice were investigated. Biodistribution study of the NGO sheets (intravenously injected into male mice at dose of ∼2000 μg/mL or 4 mg/kg of body weight) showed a high graphene uptake in testis. Hence, in vivo effects of the NGO sheets on important characteristics of spermatozoa (including their viability, morphology, kinetics, DNA damage and chromosomal aberration) were evaluated. Significant in vivo effects was found at the injected concentrations ≥200 μg/mL after (e.g., ∼45% reduction in sperm viability and motility at 2000 μg/mL). Observation of remarkable DNA fragmentations and... 

Asian red ginseng was used for green reduction of chemically exfoliated graphene oxide (GO) into reduced graphene oxide (rGO). The reduction level and electrical conductivity of the ginseng-rGO sheets were comparable to those of hydrazine-rGO ones. Reduction by ginseng resulted in repairing the sp 2 graphitic structure of the rGO, while hydrazine-rGO showed more defects and/or smaller aromatic domains. The ginseng-rGO sheets presented a better stability against aggregation than the hydrazine-rGO ones in an aqueous suspension. Whilst the hydrophobic hydrazine-rGO films exhibited no toxicity against human neural stem cells (hNSCs), the hydrophilic GO and ginseng-rGO films (as more... 

Vigorous debates have taken place within and between many countries about regulatory policy regimes covering the assessment and approval of genetically modified (GM) crops. In Iran, a very vigorous and hotly contested policy debate concerning legislation covering GM crops occurred between 2004 and 2009, but it was confined within government circles with almost no public discussion. This paper analyses the Iranian policy-making process in the period 2006-9. It explains how and why a stalemate arose in disputes between ministries and departments. The chosen analytical framework draws mainly on the regulation of technological risks and the analysis of public policy-making. It deploys the... 

A μ-way latin trade of volume s is a set of μ partial latin rectangles (of inconsequential size) containing exactly the same s filled cells, such that if cell (i, j) is filled, it contains a different entry in each of the μ partial latin rectangles, and such that row i in each of the μ partial latin rectangles contains, set-wise, the same symbols and column j, likewise. In this paper we show that all μ-way latin trades with sufficiently large volumes exist, and state some theorems on the non-existence of μ-way latin trades of certain volumes. We also find the set of possible volumes (that is, the volume spectrum) of μ-way latin trades for μ = 4 and 5. (The case μ = 2 was dealt with by Fu,... 

The set of integers k for which there exist three latin squares of order n having precisely k cells identical, with their remaining n2 -k cells different in all three latin squares, denoted by I3[n], is determined here for all orders n. In particular, it is shown that I3[n] = {0,.,n2 -15}U [n2 - 12,n2-9,n2], for n ≫8. ©2002 Eisevier Science B.V. All rights reserved  

Coronary angiography is a vital instrument to detect the prevailing of vascular diseases, and accurate vascular segmentation acts a crucial role for proper quantitative analysis of the vascular tree morphological features. Level set methods are popular for segmenting the coronary arteries, but their performance is related to suitable start-up and optimum setting of regulating parameters, essentially done manually. This research presents a novel fuzzy level set procedure with the objective of segmentation of the coronary artery tree in 2-D X-ray angiography as automatically. It is clever to clearly develop from the early segmentation with spatial fuzzy grouping. The adjusting parameters of... 

Visual attributes are great means of describing images or scenes, in a way both humans and computers understand. In order to establish a correspondence between images and to be able to compare the strength of each property between images, relative attributes were introduced. However, since their introduction, hand-crafted and engineered features were used to learn increasingly complex models for the problem of relative attributes. This limits the applicability of those methods for more realistic cases. We introduce a deep neural network architecture for the task of relative attribute prediction. A convolutional neural network (ConvNet) is adopted to learn the features by including an... 

We present the first public code for the calculation of the astrometric centroid shift occurring during microlensing events. The computation is based on the contour integration scheme and covers single and binary lensing of finite sources with arbitrary limb darkening profiles. This allows for general detailed investigations of the impact of finite source size in astrometric binary microlensing. The new code is embedded in version 3.0 of vbbinarylensing, which offers a powerful computational tool for extensive studies of microlensing data from current surveys and future space missions. © 2021 The Author(s) Published by Oxford University Press on behalf of Royal Astronomical Society  

The possibility of real-time tuning of optical devices has attracted a lot of interest over the last decade. At the same time, coming up with simple lithography-free structures has always been a challenge in the design of large-area compatible devices. In this work, we present the concept and the sample design of an electrically tunable, lithography-free, ultra-thin transmission-mode color filter, the spectrum of which continuously covers the whole visible region. A simple Metal-Insulator-Metal (MIM) cavity configuration is used. It is shown that using the electro-optic dielectric material of 4-dimethyl-amino-N-methyl-4-stilbazoliumtosylate (DAST) as the dielectric layer in this... 

Magnetic flux leakage is the most widely used method for oil and gas pipeline non destructive testing. The saturation level of the sample under test has a significant effect on its efficiency; therefore, the magnetizing yoke requires an elaborate design. The finite element method is the conventional approach used for this purpose, but it is very time consuming. In this article, a neuro-fuzzy method is presented to model the behavior of the magnetizing yoke. Modeling a few different designs with the finite element method and using the results for training the neuro-fuzzy model eradicates the necessity of modeling a huge number of designs with the finite element method. The acquired... 

The problem of finding necessary and sufficient conditions to decompose a complete tripartite graph K(r, s, t) into 5-cycles was first considered by Mahmoodian and Mirzakhani (1995). They stated some necessary conditions and conjectured that these conditions are also sufficient. Since then, many cases of the problem have been solved by various authors; however the case when the partite sets r ≤ s ≤ t have odd and distinct sizes remains open. A necessary condition is t ≤ 3r. Billington and Cavenagh (2011) have shown that when r, s, and t are all odd and r ≤ s ≤ t ≤ κr, where κ ≈ 1.0806, then the conjectured necessary conditions for decomposing are also sufficient. We extend this result... 

Graphene oxide nanoplatelets (GONPs) with extremely sharp edges (lateral dimensions ∼20-200 nm and thicknesses <2 nm) were applied in extraction of the overexpressed guanine synthesized in the cytoplasm of leukemia cells. The blood serums containing the extracted guanine were used in differential pulse voltammetry (DPV) with reduced graphene oxide nanowall (rGONW) electrodes to develop fast and ultra-sensitive electrochemical detection of leukemia cells at leukemia fractions (LFs) of ∼10-11 (as the lower detection limit). The stability of the DPV signals obtained by oxidation of the extracted guanine on the rGONWs was studied after 20 cycles. Without the guanine extraction, the DPV peaks... 

Specific and sensitive electroanalysis of blood-circulating protein cancer biomarkers is often complicated by interference from serum proteins nonspecifically adsorbing at the biosensing interface and masking specific reactions of interest. Here, we have developed an electrocatalytically amplified assay for specific and sensitive analysis of human epidermal growth factor receptor-2 (HER-2/neu, a protein cancer biomarker over-expressed in breast cancers) that allows us to avoid both the interference from bovine serum albumin (BSA) and electrocatalytic amplification of the signal stemming from the specific aptamer−HER-2/neu binding. A HER-2/neu-specific thiolated aptamer sequence was...