HAP/Agar Nanocarriers for Bone Anti-infection Drug

, M.Sc. Thesis Sharif University of Technology Ghazagh, Parisa (Author) ; Frounchi, Masood (Supervisor)

Abstract

Successful treatment of bone infections is a major orthopedic challenge due to the physiological and anatomical features of bone. In this project, we prepared a drug delivery system with injectable and biodegradable polysaccharide agar containing alginate, polyvinyl alcohol and hydroxyapatite nanocarriers composite microspheres. Alginate and polyvinyl alcohol composite microspheres are crosslinked by calcium and freeze-thawing technique. Using the freeze thawing process for polyvinyl alcohol crosslinking, in addition to alginate crosslinking, improved hydrogel swelling behavior and enhanced drug loading and thus slowed drug release, drug loading increased with increasing PVA percentage from ...

The Study of Effective Parameters on Thorium Extraction by Cyanex 272 in an Emulsion Liquid Membrane System

, M.Sc. Thesis Sharif University of Technology Ehyaie, Darya (Author) ; Samadfam, Mohammad (Supervisor) ; Zaheri, Parisa (Supervisor) ; Zahakifar, Fazel (Co-Supervisor)

Abstract

This study used the emulsion liquid membrane method to investigate the extraction and separation of thorium from nitrate solution. According to the results obtained from the studies, Cyanex 272 was a suitable option for selectively extracting thorium. For simultaneous extraction and stripping of thorium from dilute aqueous solutions, an emulsion liquid membrane system consisting of Cyanex 272 as an extractant, Span 80 as a surfactant and sulfuric acid solution as a receiving phase (internal phase) was used. Emulsion liquid membrane method has high mass transfer flux due to high surface to volume ratio, which causes high extraction efficiency and fast transfer of thorium ions from its low...

Experimental Study of Drying and Calcination of Simulated High-Level Waste (HLW)

, M.Sc. Thesis Sharif University of Technology Farahzadi, Zahra (Author) ; Samadfam, Mohammad (Supervisor) ; Zahakifar, Fazel (Supervisor) ; Zaheri, Parisa (Co-Supervisor)

Abstract

One of the novel methods of stabilization of nuclear waste is the use of vitrification technology. In order to stabilize high level wastes (HLLW) in glass, it is required that the elements are in their oxide form. Therefore, it is necessary to evaporate the waste and turn it into a solid form so that the elements can be converted into oxide form in the calcination furnace. Hence, one of the challenges of stabilization is the optimization of evaporation and calcination conditions. In this research, the parameters affecting evaporation were first investigated. Using laboratory measurements of application: temperature (110 to 180 °C), presence of nitric acid (0.5 to 4 mol/L), ratio of zirconium...

Fabrication Patient-Specific Drill Guide Templates for Cervical Pedicle Screw Placement

, M.Sc. Thesis Sharif University of Technology Safahieh, Amir Hossein (Author) ; Arjmand, Navid (Supervisor) ; Parnianpour, Mohammad (Supervisor) ; Azimi, Parisa (Co-Supervisor)

Abstract

One of the most common spinal surgeries involves spinal fusion or vertebral fixation, which is used to treat various conditions such as intervertebral disc disease, scoliosis (lateral deviation of the spinal column), fractures, infections, or the presence of tumors in the spinal column. In this surgical procedure, the use of pedicle screws and titanium rods prevents motion and friction between two vertebrae. Screws may enter the vertebrae in the wrong position and angle, causing bone weakening, rupture of nerve roots or blood vessels, weakness or lack of sensation in some parts of the body, spinal cord injury, and in severe cases, paralysis of the patient. For this reason, fusion surgery is...