Loading...
Search for:
gheysari--hengameh
0.069 seconds
Drug-target Interaction Prediction through Learning Methods for SARS-COV2 Based on Sequence and Structural Data
, M.Sc. Thesis Sharif University of Technology ; Koohi, Somayyeh (Supervisor)
Abstract
Predicting the binding affinity of drug molecules and proteins is one of the most important stages of drug discovery, development and screening, for which numerous laboratory, simulation and computational solutions have been provided. Laboratory and simulation methods require molecular structures, are time and financial expense, and computational methods do not provide accurate predictions. Therefore, the use of deep neural networks in extracting features from data with a simpler and more accessible structure of protein sequences and molecules solves these challenges with lower cost and higher accuracy. In this article, the use of a new molecular sequence named selfies, which has solved the...
Debismuthizing of Lead with Alkaline and alkaline Earth Elements
, M.Sc. Thesis Sharif University of Technology ; Yoozbashizadeh, Hossein (Supervisor) ; kaflou, Ali (Supervisor)
Abstract
Lead produced by pyrometallurgy method has a number of impurities. Most of these eimpurities can easily be removed, but this property does not apply in the case of bismuth. Since chemical properties of bismuth are close to the lead, refining of bismuth below 250 ppm is difficult and expensive. Because of problems related to electrochemical discussion of the batteries, bismuth it is possible to reduce below than 20 ppm. Jollivet and Dittmer process is capable of reducing bismuth below 20 ppm. As the main goal of this project is to reduce bismuth to small amounts, Jollivet process was used. Potassium needed for Jollivet process, produced by electrolysis of Potassium chloride salt....
Preparation and Characterization of Hydroxyapatite Nanostructures Using Natural Resources for Bone Scaffold Applications
, M.Sc. Thesis Sharif University of Technology ; Simchi, Abdolreza (Supervisor) ; Askari, Masoud (Supervisor)
Abstract
This investigation presents synthesis and characterization of pure and monophasic hydroxyapatite (Ca10(PO4)6(OH)2; HA) Nanostructures prepared by coral and oyster shell powders heated at 800 oC for 8 h as precursor via precipitation method. The morphology of HA nanostructures was controlled in the presence of various surfactants such as SDS, CTAB and PVP. The HA Nanorods synthesized by SDS were applied to fabricate bone scaffolds. Particle sizes of the HA Nanoparticles were about 20-30 nm. Pours three-dimensional HA/Ge/CMC scaffolds cross-linked by citric and oxalic acids were synthesized. In order to increase the pore size of the scaffolds, NaCl with medium (180-250 µm) and large (420-500...
Extraction of hydroxyapatite nanostructures from marine wastes for the fabrication of biopolymer-based porous scaffolds
, Article Marine Drugs ; Volume 18, Issue 1 , 2020 ; Mohandes, F ; Mazaheri, M ; Dolatyar, B ; Askari, M ; Simchi, A ; Sharif University of Technology
MDPI AG
2020
Abstract
Three-dimensional porous nanocomposites consisting of gelatin-carboxymethylcellulose (CMC) cross-linked by carboxylic acids biopolymers and monophasic hydroxyapatite (HA) nanostructures were fabricated by lyophilization, for soft-bone-tissue engineering. The bioactive ceramic nanostructures were prepared by a novel wet-chemical and low-temperature procedure from marine wastes containing calcium carbonates. The effect of surface-active molecules, including sodium dodecyl sulfate (SDS) and hexadecyltrimethylammonium bromide (CTAB), on the morphology of HA nanostructures is shown. It is demonstrated that highly bioactive and monophasic HA nanorods with an aspect ratio > 10 can be synthesized in...