Loading...
Search for:
hadisi--maliheh
0.036 seconds
Study of Effects of Operational Parameters on Flooding in Pertraction of Dysprosium in a Vertical Pulsed Packed Column
, M.Sc. Thesis Sharif University of Technology ; Bastani, Dariush (Supervisor) ; Safdari, Jaber (Supervisor) ; Raji, Maliheh (Co-Supervisor)
Abstract
Pulsed packed columns are among the most important devices used in liquid-liquid extraction, with wide application in petroleum and petrochemical industries, metal salt extraction, pharmaceutical industries, metallurgy, and other areas. Liquid-membrane technology is an alternative separation technique to the liquid-liquid extraction for the extraction and recovery of metal ions from aqueous solutions. There are three main types of liquid membranes: emulsion liquid membrane (ELM), Bulk Liquid Membrane (BLM), and Supported Liquid Membrane (SLM). Liquid emulsion membrane is one of the pertraction methods with phase dispersion. It is a three-phase dispersion system, consisting: external phase,...
Preclinical evaluation of 188 Re-HYNIC-PSMA as a novel therapeutic agent
, Article Journal of Radioanalytical and Nuclear Chemistry ; Volume 331, Issue 2 , 2022 , Pages 841-849 ; 02365731 (ISSN) ; Vosoughi, N ; Yousefnia, H ; Bahrami-Samani, A ; Zolghadri, S ; Vosoughi, S ; Alirezapour, B ; Sharif University of Technology
Springer Science and Business Media B.V
2022
Abstract
In this study, optimized preparation, quality control, cell assessments and biostribution of 188Re-HYNIC-PSMA in normal rats and tumor bearing mice are studied. Optimized conditions for radiolabeling were evaluated and radiochemical purity (> 99%) was investigated using ITLC and HPLC methods. 188Re-HYNIC-PSMA was stable both in PBS (4 °C) and in human serum (37 °C) even after 48 h. The results showed the complex was cleared from the blood very fast via urinary track. This new radiolabeled compound has a high potential to be considered as an agent for the treatment of patients with PSMA expressing tumors however more biological studies are still needed. © 2022, Akadémiai Kiadó, Budapest,...
Mathematical Modeling of 188Re-PSMA in Rats and its Human Absorbed dose Estimation
, M.Sc. Thesis Sharif University of Technology ; Vosoughi, Naser (Supervisor) ; Yousefnia, Hassan (Supervisor) ; Bahrami Samani, Ali (Co-Supervisor)
Abstract
Prostate cancer is the second most common cancer in men and the fourth leading cause of death in the world. In this study, the 188Re-HYNIC-PSMA radiolabeled compound was produced as a compound for use in the treatment of prostate cancer and its metastases under optimal labeling conditions and its radiochemical purity was obtained above 98% using RTLC and HPLC chromatographic methods. This compound is stable at room temperature and in human blood serum for at least 48 hours after preparation. The biological distribution of this compound was investigated in each rat tissue and the amount of injected activity per unit mass of each tissue (%ID/g) was determined. The bio-distribution of 188...