Sharif Digital Repository

The results of highthroughput practical single channel experiments should be formulated and validated by signal analysis approaches to increase the recognition precision of translocating molecules. For this purpose, the activities of the single nano-pore forming protein, OmpF, in the presence of nucleotides were recorded in real time by the voltage clamp technique and used as a means for nucleotide recognition. The results were analyzed based on the permutation entropy of current Time Series (TS), fractality, autocorrelation, structure function, spectral density, and peak fraction to recognize each nucleotide, based on its signature effect on the conductance, gating frequency and voltage... 

We consider chaperone-assisted translocation of biopolymers with two distinct monomers or bases A and B, with the size of the chaperones being λα, where α is a monomer's size. The probability that A and B are neighbors in the biopolymer is PAB. A master equation is used, together with the detailed-balanced condition, in order to derive analytical results for the statistics of the first-passage times of the biopolymer as a function of PAB, λ, and the biopolymer's configuration. Monte Carlo simulations have also been carried out in order to compute the same quantities for biopolymers with 100-900 monomers and several λ. The results indicate nontrivial dependence of the variance of the... 

We study the translocation of stiff polymers through a nanopore, driven by the chemical-potential gradient exerted by binding proteins (chaperones) on the trans side of the pore. Bound chaperones prevent backsliding through the pore and, therefore, partially rectify the polymer passage. We show that the sequence of chain monomers with different binding affinity for the chaperones significantly affects the translocation dynamics. In particular, we investigate the effect of the nearest-neighbor adjacency probability of the two monomer types. Depending on the magnitude of the involved binding energies, the translocation speed may either increase or decrease with the adjacency probability. We... 

Combining the advection-diffusion equation approach with Monte Carlo simulations we study chaperone driven polymer translocation of a stiff polymer through a nanopore. We demonstrate that the probability density function of first passage times across the pore depends solely on the Péclet number, a dimensionless parameter comparing drift strength and diffusivity. Moreover it is shown that the characteristic exponent in the power-law dependence of the translocation time on the chain length, a function of the chaperone-polymer binding energy, the chaperone concentration, and the chain length, is also effectively determined by the Péclet number. We investigate the effect of the chaperone size on... 

This paper attempts to develop the optimal solution for an inventoryproblem consisting of a single machine which produces items some of which may bedefective. We assume that no shortages are allowed and all defective items areto be reworked. Setup cost for rework and waiting time of defectives areconsidered. We consider two different policies where in the first policy in eachcycle after the regular production the machine is setup for the rework ofdefectives of the same cycle. In the second policy several cycles constitute aperiod. All the defectives produced in the period are reworked in the last cycleof that period. At the end of the rework cycle the whole process starts allover again. One... 

This paper deals with a two-echelon inventory system consisting of onesupplier and N retailers. Each retailer faces an independent Poisson demand withthe same rate and applies a new ordering policy called one-for-one- periodordering policy for its inventory control. In this ordering policy the ordersize is equal to one and the time interval between any two consecutive ordersforms a common fixed cycle. Thus, the supplier faces a deterministic demand andadopts a deterministic inventory policy. At each cycle he orders a batch of sizeN to his own supplier. Upon receipt of each batch he sends 1 unit of theproduct to each retailer with a transportation cost. In this paper, for theabove system we... 

In this article, we design a revenue-sharing contract to coordinate inventory control decisions in a serial supply chain consisting of one supplier, one vendor, and one retailer. We assume that the retailer faces Poisson demand and his unsatisfied demands will be lost. The retailer applies one-for-one period policy in which he constantly places an order for one unit of product to the vendor in a predetermined time interval which results in a deterministic demand for the vendor. Vendor orders the required quantity from supplier which will be immediately received at the vendor’s warehouse. Solution procedures are developed to find the equilibrium in the vendor managed inventory program with a... 

In this paper, we design a revenue sharing contract to coordinate pricing and inventory control decisions in a serial supply chain consisting of one supplier, one manufacturer and one retailer. We assume that the retailer faces Poisson demand and his unsatisfied demands will be lost. The retailer applies one-for-one period policy in which he constantly places an order for one unit of product to the manufacturer in a predetermined time interval which results in a deterministic demand for the manufacturer. Solution procedures are developed to find the equilibrium in the Vendor Managed Inventory (VMI) program with a revenue sharing contract, in which no party is willing to deviate from for the... 

In this paper, we develop an inventory model with price dependant demand rate, under time value of money and inflation, finite time horizon, exponential backlogging rate and exponential deterioration rate with the objective of maximizing the present worth of the total system profit. Using a dynamic programming based solution algorithm, we are able to find the optimal sequence of the cycles and also to obtain different optimal selling prices and optimal order quantities for the cycles with unequal lengths, which have never been done before for our model. We also use a proper numerical example to show accuracy of the solution procedure. © 2008 IEEE  

The purpose of this paper is to adopt and analyze a new ordering policycalled one-for-one-period policy in a multi-echelon supply chain consisting ofone retailer and a series of TV suppliers. The main advantage of adopting theone-for-one-period (7,7) ordering policy for retailers is the elimination ofuncertainty for supplier which leads to total elimination of the safety stocksat all suppliers. This in turn leads to the reduction of the total system costsand in case any supplier's ordering cost is negligible it can even eliminate theneed for him to carry any inventory. In addition to this advantage, thenumerical results show that the application of this new policy for the retailerleads to... 

This paper deals with the issue of economic batch quantity (EBQ) in a single machine system in which defective items are produced in each cycle of production. The accumulated defective items produced in a period, consisting of several equal cycles, are all reworked in the last cycle of this period called the rework cycle. At the end of each period the whole process will start all over again. We assume that there is a limitation on the total defective items. We also do not adopt the restriction that the rework process rate be equal to the normal production rate. In addition we assume that there is a set up time for rework process. Further we assume that the number of rework cycles be as small... 

This paper deals with the issue of economic batch quantity (EBQ) in a single machine system in which defective items are produced in each cycle of production. The defective items produced in the first N cycles are accumulated at the end of the Nth cycle and are all reworked in a separate cycle called the rework cycle which has the same length as the other cycles and begins just at the end of the Nth cycle. At the end of the rework cycle the whole process will start all over again. For this system, assuming no shortages are permitted we obtain the economic batch quantity which minimizes the total cost  

Synthesis and swelling behavior of a new superabsorbent hydrogel based on natural salep grafted with polyacrylamide is described. The new superabsorbent hydrogel biopolymer was synthesized via radical crosslinking and graft copolymerization of acrylamide monomer onto salep backbones. Regarding to the water absorption of hydrogel, the best synthesis condition is reported. FTIR spectroscopy and thermogravimetric analysis were used to confirm the structure of the final product and a mechanism for superabsorbent hydrogel formation was also suggested. After preparing the desired hydrogels based on optimum condition, several factors affecting the swelling behavior of hydrogel including pH of...