Sharif Digital Repository

Since the injection of the oncolytic viruses in the virotherapy process reduces the toxicity and drug resistance inherent in the chemotherapy; chemovirotherapy as a novel combination therapy has become an efficient cancer treatment. The primary purpose of this paper is to design a robust optimal control strategy for the chemovirotherapy through which the tumor density decreases to its stable condition with limited drug and virus delivery. This desired treatment should be responsive in the presence of input disturbances and parametric uncertainties. In this regard, an ODE (Ordinary Differential Equation) mathematical model of the chemovirotherapy process presenting the connection between the... 

This paper presents the feedback linearization control of HIV infection. A multi-input multi-output (MIMO) dynamic nonlinear HIV infection model for this purpose has been used. For this purpose, three widely used drugs are considered. A Luenberger-like nonlinear observer (LNO) is designed for estimation of unavailable states. To minimize the side effects of drugs, the concentration of ZDV which has the highest side effect is fixed to a minimum value and the external controllers parameters are obtained by maximizing an objective function. In the control design, limitations on drug consumption and unavailability of all states are taken into account. The closed-loop stability has been... 

In this paper, Quad-Tree decomposition method is applied for areal upscaling of irregular shaped petroleum reservoirs. Quad-Tree decomposition is a recursive data structuring technique which generates an upscaled model with non-uniform (unstructured) gridblocks. This type of coarsening reduces the number of gridblocks, but preserves the main heterogeneity features of the original fine model. Because of the quadruplet nature of the Quad-Tree decomposition, this method cannot be used for upscaling of irregular-shaped models, directly. In this study, by circumscribing a square to the irregular-shaped reservoirs, a temporary model is obtained which can be upscaled by Quad-Tree decomposition.... 

Ship transportation is increasing globally as is the risk of collision especially in congested areas. Numerical modeling method is a major simulation method to predict ship maneuverability. Ship maneuvering in calm water is an important topic to avoid collisions and leads to safe navigation. Therefore, reliable ship maneuvering simulations are required for incident analysis and prevention. In recent time within the research community orientated towards ship hydrodynamics an increasing attention has been paid to simultaneous solution of the planing ship maneuvering problem. The maneuverability of planing craft has been the subject of many research projects during the last few decades. To... 

Fluid flow behavior in a porous medium is a function of the geometry and topology of its pore space. The construction of a three dimensional pore space model of a porous medium is therefore an important first step in characterizing the medium and predicting its flow properties. A stochastic technique for reconstruction of the 3D pore structure of unstructured random porous media from a 2D thin section training image is presented. The proposed technique relies on successive 2D multiple point statistics simulations coupled to a multi-scale conditioning data extraction procedure. The Single Normal Equation Simulation Algorithm (SNESIM), originally developed as a tool for reproduction of... 

In the recent years, different mathematical models have been suggested for maneuvering of displacement vessels that are capable of estimation of vessel maneuvers with acceptable precision. These mathematical models are based on determined hydrodynamic coefficients and their accuracy depends on the known coefficients used to solve the mathematical model. System identification methods are developed to calculate these coefficients utilizing input and output data obtained from different sources. In this research, a 4.36-m model of KRISO Container Ship (KCS) displacement vessel has been manufactured by fiberglass, and the maneuver turning tests have been carried by self-propulsion method. A... 

In the recent years, different mathematical models have been suggested for maneuvering of displacement vessels, which are capable to estimate maneuvering of the vessel with acceptable precision. But, simulation of planing craft maneuverability through a mathematical model has not been developed yet. In this paper, a mathematical model is developed for maneuvering of the planing craft by including the rudder forces and moments. Different maneuvers, such as straight-line stability, course keeping, and turning circle, are executed through the mathematical model. Simulation results are validated with the published experimental results and it is shown that they are in good agreement. Finally, the...