Sharif Digital Repository

The objective of this article is to study gas temperature estimation in a partially filled rotating cylinder. From the measured temperatures on the shell, an inverse analysis is presented for estimating the gas temperature in an arbitrary cross-section of the aforementioned system. A finite-volume method is employed to solve the direct problem. By minimizing the objective function, a hybrid effective algorithm, which contains a local optimization algorithm, is adopted to estimate the unknown parameter. The measured data are simulated by adding random errors to the exact solution. The effects of measurement errors on the accuracy of the inverse analysis are investigated. Two optimization... 

Ultrasound hyperthermia is used to treat tumors in human tissue by heat. It is characterized by the application of high intensity focused ultrasound (HIFU), high local temperatures and short treating time of a few seconds. HIFU is a non-invasive treatment modality for a variety of cancers, including breast, prostate, kidney, liver, bone, uterus, and pancreatic cancers. Computer models have been used to determine tissue temperatures during ultrasound hyperthermia. In this work, we consider a liver tissue with a tumor at its center. We calculated temperature distribution in the presence a large blood vessel. We studied the effect of varying the exposure time (heating duration) and the diameter... 

We propose and analyze a circularly polarized slot antenna built on a ferrite substrate which is saturated normal to its plane and metalized on both sides. The antenna is built by etching a circular slot in the top metal layer. The antenna operates in the frequency range where the effective permeability of ferrite is negative. An accurate analytical model is derived for the antenna by solving the integral equation for the electric field on the circular slot. The results obtained are in good agreement with numerical simulations. Using the analytical results, a practical antenna is designed that uses a microstrip feed line. For an antenna with inner and outer radii of 4.9 and 5.9 mm, the... 

Background: Chinese hamster ovary (CHO) cell line is considered as the most common cell line in the biopharmaceutical industry because of its capability in performing efficient post-translational modifications and producing the recombinant proteins, which are similar to natural human proteins. The optimization of the upstream process via different feed strategies has a great impact on the target molecule expression and yield. Methods: To determine and understand the molecular events beneath the feed effects on the CHO cell, a label-free quantitative proteomic analysis was applied. The proteome changes followed by the addition of a designed amino acid feed to the monoclonal antibody producing... 

A fuzzy controller has been suggested for attitude control of magnetic actuated satellites in order to calculate the desired mechanical torque based on the attitude error including error in the angles and their rates. The problem of selecting proper magnetic dipole based on the known desired mechanical torque has been investigated, two different methods for the purpose has been suggested and the performance of the attained fuzzy magnetic attitude controllers has been shown under two different simulated conditions. © 2009 IEEE  

Cell culture feeds optimization is a critical step in process development of pharmaceutical recombinant protein production. Amino acids are the basic supplements of mammalian cell culture feeds with known effect on their growth promotion and productivity. In this study, we reported the implementation of the Plackett-Burman (PB) multifactorial design to screen the effects of amino acids on the growth promotion and productivity of a Chinese hamster ovary DG-44 (CHO-DG44) cell line producing bevacizumab. After this screening, the amino acid combinations were optimized by the response surface methodology (RSM) to determine the most effective concentration in feeds. Through this strategy, the... 

In this paper, a continuous model for flexural vibration of beams with a vertical edge crack including the effects of shear deformation and rotary inertia is presented. The crack is assumed to be an open-edge crack perpendicular to the neutral plane. A quasi-linear displacement filed is suggested for the beam, and the strain and stress fields are calculated. The governing equation of motion for the beam has been obtained using Hamilton principle. The equation of motion is solved with a modified weighted residual method, and the natural frequencies and mode shapes are obtained. The results are compared to the results of similar model with Euler–Bernoulli assumptions and finite element model... 

In this study, biodegradation of corn starch/glycerol/Na-MMT nanocomposites by soil burial tests were carried out for up to 6 months. Films were prepared by casting method according to central composite design and response surface methodology was applied for analysis of the results. The effects of formulation on the water solubility, contact angle and tensile strength of starch films were investigated. Increasing in Na-MMT content decreased biodegradability; while presence of glycerol, increased it. The effect of nanoparticles content might have been attributed to interactions between starch and Na-MMT that further prevented enzymatic attack on the biopolymer. In addition, the films with... 

In this research, response surface methodology (RSM) was applied to study the effects of Na-Montmorillonite (Na-MMT) and glycerol on some functional properties of corn starch films. Films were prepared by casting method according to central composite design (CCD). Originally image processing technique was used in order to estimate transparency of the films. It was found that Na-MMT absorbed UV light from 216 to 266. nm. No antimicrobial activities were observed against Escherichia coli and Staphylococcus aureus. Contact angle analysis revealed hydrophilicity of starch films decreased utilizing nanoparticles and increased with plasticizer content. Increase in glycerol content decreased... 

This paper presents an algorithm for synchronizing two different chaotic systems by using a combination of Unscented Kalman-Bucy Filter (UKBF) and sliding mode controller. It is assumed that the drive chaotic system is perturbed by white noise and shows stochastic chaotic behavior. In addition the output of the system does not contain the whole state variables of the system, and it is also affected by some independent white noise. By combining the UKBF and the sliding mode control, a synchronizing control law is proposed. Simulation results show the ability of the proposed method in synchronizing chaotic systems in presence of noise  

In this paper, a continuous model for vibration analysis of a beam with an open edge crack including the effects of shear deformation and rotary inertia is presented. A displacement field is suggested for the beam and the strain, and stress fields are calculated. The governing equation of motion for the beam has been obtained using Hamilton's principle. The equation of motion is solved with a modified Galerkin method and the natural frequencies and mode shapes are obtained. A good agreement has been observed between the results of this research and the results of previous work done in this fiels. The results are also compared to results of a similar model with Euler-Bernoulli assumptions to... 

A new nonlinear optimization method for parameter estimation in Michaelis-Menten equation has been developed. This method is based on a special mathematical form of the Michaelis-Menten equation to finding the best fit of the linear plot of R versus S/(S + Km) where R, S, and Km are the reaction rate, concentration of substrate, and the Michaelis-Menten constant, respectively. By setting the intercept of this line to zero, the proper Km will be obtained and the slope would give the saturation rate, Vmax. As a result, a nonlinear, two-parameter optimization is simplified into finding the roots of a nonlinear equation. Generated data sets were used... 

A new wearable assistive device (WAD) was developed to decrease required force on the lumbar spine in static holding tasks. In order to obtain moments on lumbar spine in two conditions, with and without WAD, a biomechanical static model was used for estimation of external moments on lumbar spine. The results of biomechanical models indicated that there was a reduction in the lumbar moment ranging from 20% to 43% using WAD depending on the load and flexion angle. A total of 15 male healthy subjects were tested to experimentally verify the predicted reduction of external moments on the spine by wearing WAD. Normalized electromyography (EMG) of the right and left lumbar and thoracic erector... 

We propose two nonlinear regression methods, namely, Adversarial Orthogonal Regression (AdOR) for additive noise models and Adversarial Orthogonal Structural Equation Model (AdOSE) for the general case of structural equation models. Both methods try to make the residual of regression independent from regressors, while putting no assumption on noise distribution. In both methods, two adversarial networks are trained simultaneously where a regression network outputs predictions and a loss network that estimates mutual information (in AdOR) and KL-divergence (in AdOSE). These methods can be formulated as a minimax two-player game; at equilibrium, AdOR finds a deterministic map between inputs... 

In this paper, an algorithm for fault diagnosis of permanent magnet DC electromotors.has been investigated, based on vibration and electrical current monitoring. Several permanent magnet DC electromotors.with previously determined faults have been prepared and the vibration, current and speed data have been measured. The relationship between certain related measured data and faults has been determined. A fault diagnosis algorithm has been developed in this research based on these relationships. This algorithm can be used in mass production lines for quality control  

Signed graphs are graphs whose edges get signs ±1 and, as for unsigned graphs, they can be studied by means of graph matrices. Here we focus our attention to the largest eigenvalue, also known as the index of the adjacency matrix of signed graphs. Firstly we give some general results on the index variation when the corresponding signed graph is perturbed. Also, we determine signed graphs achieving the minimal or the maximal index in the class of unbalanced unicyclic graphs of order n≥3. © 2019  

In this work, two important opioid antagonists, naltrexone and oxycodone, were prepared from thebaine and were characterized by IR, 1H NMR and 13C NMR spectroscopy. Moreover, computational NMR and IR parameters were obtained using density functional theory (DFT) at B3LYP/6-311++G* * level of theory. Complete NMR and vibrational assignment were carried out using the observed and calculated spectra. The IR frequencies and NMR chemical shifts, determined experimentally, were compared with those obtained theoretically from DFT calculations, showed good agreements. The RMS errors observed between experimental and calculated data for the IR absorptions are 85 and 105 cm-1, for the 1H NMR peaks are... 

Carbide morphologies of white cast iron containing 22% Cr and 10-12% tungsten with different carbon contents (2.34-3.20. wt.%) were investigated. Results indicated that for the as-cast alloys with no heat treatments, the addition of carbon changes the morphology of carbides during air-cooling in the presence of tungsten. Light microscopy analysis revealed that for an alloy with 2.3. wt% carbon, chromium carbides possess coarse gray appearance (GA). Increasing the carbon content reduced the coarse GA zones volume fraction while a finer GA zones emerged. The coexistence of coarse and fine GA phases came to an end at 2.8. wt% carbon, at which only fine GA zones spread throughout the chromium... 

In the present study, oblique low-velocity impact (OLVI) on GLARE fiber-metal laminates (FMLs) has been modeled using finite element analysis (FEA) for the first time. Two types of boundary conditions (BCs) can be considered for impactor in the low-velocity impact: constrained (if the impact angle between the impactor and target remains constant during and after the contact) and free (if rotation of the impactor and change in angle with respect to the target is likely) BCs. The more details of these BCs are described in the paper. The OLVI is numerically modeled for four different impact angles. Effect of BC types and impact angle on energy absorption, as well as maximum contact force, is... 

In the present study, oblique low-velocity impact (OLVI) on GLARE fiber-metal laminates (FMLs) has been modeled using finite element analysis (FEA) for the first time. Two types of boundary conditions (BCs) can be considered for impactor in the low-velocity impact: constrained (if the impact angle between the impactor and target remains constant during and after the contact) and free (if rotation of the impactor and change in angle with respect to the target is likely) BCs. The more details of these BCs are described in the paper. The OLVI is numerically modeled for four different impact angles. Effect of BC types and impact angle on energy absorption, as well as maximum contact force, is...