Sharif Digital Repository

Prostate cancer is the second leading cause of cancer-related mortality in men after lung cancer. Prostate-specific membrane antigen (PSMA-617) labeled with Actinium-225 (225Ac) is currently being studied as a potential treatment for metastatic castration-resistant prostate cancer. This study aimed to produce the labeled compound [225Ac]Ac-PSMA-617 for the treatment of prostate cancer and its metastases. The compound was synthesized under optimized labeling conditions, and its radiochemical purity was determined to be over %96 using RTLC chromatography method. The biodistribution of the compound was evaluated in the tissues of healthy male mice, and the injected activity per unit mass of... 

Euthanasia is one of the most controversial topics in medical ethics and in the areas of religion, law and ethics are studied .Different approaches to the authorities in case of euthanasia on the ballot, specifically rooted in the philosophical approach, to their beliefs and culture. According to the above description. The main objective of this paper is to study the philosophical approach of euthanasia. Therefore, this text answer three main questions. The first question will be discussed in the first chapter is that "How general philosophical issues applied to specific cases such as euthanasia?" The second question is about the definition and types of euthanasia .This question will be... 

After restructuring in power systems, Independent System Operators (ISO's) are looked for an appropriate auction mechanism to find the market operation point. In deregulated electricity markets, Offer Cost Minimization (OCM) auction is used to minimize the total bid cost for selecting offer and demand bids. But a uniform market clearing price (MCP) or Locational Marginal Price (LMP) is used for consumer payments. Hence, the minimized bid cost is different from settlement cost. The used mechanisms are for manufactures offer and their cost functions optimization. The Payment Cost Minimization (PCM) is one of the mechanims that affect directly on the consumers payment and lead to reduction of... 

Global collapse in earthquake engineering refers to the inability of a structural system to sustain gravity loads when subjected to seismic excitation. Dynamic instability phenomena in exist buildings have a key position and for this reason strict criteria in structural seismic assessing codes presented for avoiding this phenomena. At this study, dynamic instability of five designed concrete buildings with moment frame system, mixed up 3, 6, 9, 12 and 15 story building, are investigated. P-delta effects, deterioration in strength and stiffness and cyclic deterioration in structural components considered in this investigation. For modeling nonlinear behavior of elements, experimental results... 

With increasing number of processors on a chip, the role of interconnections becomes more important in both power consumption and bandwidth. As a result, in MultiProcessor System-on-Chip architectures, the design constraints will shift from "Computational Constraints" to "Communicational Constraints". Nowadays, optical information transfer is introduced as a suitable substitution for electrical interconnections in chips, which can eliminate their problems. Many different optical networks have been presented so far. These networks can be divided into two subcategories. Networks of the first category use an electrical infrastructure as well as optical one. Hence, the scalability of scheme is... 

In the first description if we describe technology as a tool, Communication technologies or media should be consider as the most important element of today's technological world. This research is going to cover reconsidering and recreating the mean of media based on the Ideas of JacquesDerrida. In this regard, two major dichotomy is evident in the public understanding of media. meanwhile "media versus message" and on the other hand opposition between "media and audience". So deconstruction in the face of these binary oppositions, want to read out the notion that message is superior to media, and on the other hand to deconstruction of the hegemony of the media on the audience  

Nowadays, applications of the synthetic materials are developing in civil engineering projects and widely used in these projects. Therefore, during previous years; use of the Geotextiles as one of the Geosynthetic materials in order to filtration, drainage, separation, soil protection, etc have developed ever-increasing. The goal of this research is modeling and studies of the Geotextiles application in the downstream filter zone of embankment dams in combination with granular materials using FLAC2D software. Gordeh Bin embankment dam situated in West Azerbaijan province has been chosen as case study. In this matter, different models have been made with changes in thickness of the inclined... 

Prediction of groundwater level fluctuations is absolutely necessary for the proper manag ement of these precious resources. There are different methods to predict hydrological time series such as groundwater level. Linear models inefficiency in predicting nonlinear and n on-stationary time series cause researchers widely use artificial intelligence techniques such as Artificial Neural Networks (ANN), Fuzzy Inference System (FIS), Genetic Algorithm (GA) and their hybrid models such as Artificial Neural – Fuzzy Inference System (ANFIS). These smart models are capable to simulate nonlinear and non-stationary time series in suitable accu-racy using by a few time and data. By emersion of Wavelet... 

Entrance of air to close water conduits occurs in many ways. This phenomenon makes displeasing effects on water transport structures. Two-phase flows in closed conduits are studied experimentally, numerically and theoretically. Even after decades, due to the complexity of the subject, these studies still require development and reformation. Numerical and theoretical two-phase models are often limited to a special regime of flow."Volume Of Fluid"(VOF) is a model for non-mixing two-phase flows. "Fluent" software uses this model in this field of flows. Volume of fluid is used successfully in some problems like dam break or rising bubbles. Main disadvantage of this model is distribution of the... 

Groundwater quality protection has a significant importance due to abundant applications of these resources in various fields such as agriculture, industry and drinking water. Removal of groundwater pollution is a time and money consuming process and often pollution is detected when improving the quality of groundwater is nearly impossible. For this vulnerability assessment there are three methods: Processing, Overlap-Index and Statistical Methods. Overlap-Index is composed of variety of maps such as Geology, Soil, Groundwater Depth and etc which uses in determining of vulnerability Index. In the present study for underground pollution potential determining, four indexes such as AVI، GOD،... 

“Sustainable development” is a frequently used phrase, but the idiom has been experienced little since it was coined by the Brundtland, due to its intrinsic complications. The issue is going to compromise two key components; economy and ecology. One of the solutions based on concept of sustainable development that has been proposed for maintaining water quality at acceptable levels is to cap pollutant emissions at a sustainable level, then establish an economic market in which the right to discharge pollutants is traded according to market supply and demand mechanisms. Water quality trading or pollution trading is one such kind of market-based program that has also been described using names... 

Gene expression microarrays can be used for precision medicine and targeted therapies. The data generated by microarrays are high-dimensional causing statistical inference of any parameter a daunting task. In this thesis, it is shown that regardless of high-dimensional datasets produced by microarrays, the inference can be robust in the sense that random selection of features results in the same conclusion as far as the number of selected features are chosen appropriately. Stratifying patients with breast cancer based on their gene expression levels shows that patient subtypes are almost independent of the feature selection strategy. Moreover, using less noisy datasets coming from RNAseq... 

Today, computer simulations are employed prevalently by researchers to understand biological processes. The tendency to use computational methods has been increased recently due to the high costs and errors of experimental methods. Integrins are membrane proteins that mechanically attach cells to the extra cellular matrix (ECM) and derive some behaviors such as cell migration. Moreover, integrins have biochemical functions. They transduce environment signals and trigger chemical pathways. As a result, integrins regulate cell shape, motility, etc. The investigation of integrin behavior in a real environment is very difficult due to the presence of many other proteins that interfere with the... 

In this thesis, we determine the optimal capacity of the power plants considering site specifications and Flow Duration Curve and evaluating economic parameters. Finally a design with more sufficient economical and hydrualical performance would be selected. The optimization algorithm used in this thesis is called "Charged System search" that is one of the newest meta-heuristic algorithms. This algorithm is inspired by the coulomb and gauss's laws of electrostatics in physics and utilizes a number of charged particles which influence each other based on their fitness values and their separation distances considering the governing law of coulomb.The proposed method in this thesis can be... 

Coinciding with the worldwide environmental issues and increasing demand for clean energy sources, hydropower plants have highly attracted decision- makers attention. Low manufacturing costs and pollutions which are made by these plants in comparison with another types of powerhouses, could be reason of that. And so on, hydropower locating and evaluating studies have been highly increased recently, specifically in developing countries. From the point of operation procedure, hydropower plants are generally divided in two types, run-of-he-river and storage projects. This study has concentrated on run-of-he-river projects and due to spotting plant location, Sefidbarg river basin...