Sharif Digital Repository

Chemotherapy is a proven and effective systematic approach to treat various types of cancers. Despite its advantages, chemotherapy would kill healthy as well as cancer cells. To overcome this problem, different controlling strategies are implemented. This study aims to provide a medicine drug delivery schedule for chemotherapy (by designing a proper controlling system) based on the verifiable mathematical models. First, the dynamic model is analysed and stability points are reviewed. The selected model has five state variables and two inputs. In this study, the focus is on dynamic model analysis and obtaining an effective and appropriate treatment pattern by designing a proper controller. To... 

Due to the vulnerability of urban fabric and residential buildings to earthquakes and considering its destructive social and economic effects on society, the need to adopt appropriate policies to prevent and reduce vulnerability, has been increasingly considered by policy makers. Despite the laws, regulations, incentives and penalties that policymakers have envisioned to prevent unprincipled and unsafe construction, evidence shows that a significant number of new buildings being built in the country are not earthquake resistant and there are many violations in design, implementation and supervision that is done by the stakeholders. To solve this problem, research has been done on the... 

Placement of control and bracing systems in a structure is one of the most important factors affecting the effectiveness of the system in reducing responses to earthquakes. In other words, a control system with a proven effectiveness in earthquake does not reduce the structure responses unless used with proper placement. The performance of Ribbed Bracing System (RBS) in enhancing seismic response of structures, especially in preventing the buckling of bracing under compression and removing residual displacements, is approved by analytical and experimental studies, but optimal placement of such systems in structures has not been studied yet. Hence, in this research the optimal placement... 

The objective of this study is development of a probabilistic framework that facilitates the investigation of the post-earthquake performance of a network of hospitals using the Hospital Network Resilience index which quantifies the ability of the hospitals to provide treatment to earthquake victims. Disasters such as earthquakes can damage the infrastructure systems of a community, disrupt the functionality, and lead to various direct and indirect economic, social and socioeconomic consequences. Over a decade, natural disasters such as earthquakes are estimated to have caused $1.3 trillion economic losses. The social and socioeconomic losses of natural disasters are equally significant as... 

As a result of technology advancement in composite materials and the growth of analytical tools, applications of these materials is increasing in various industries, especially in aerospace industry. One of the structures developed using these materials is hybrid structure with composite/elastomer layering. Stress analysis and study of free-edge effect in this type of structures is possible by using three-dimensional elasticity in composite layers as well as nonlinear hyperelasticity in elastomeric layers, and this is the topic that this thesis deals with. The proposed approach to solving the problem is that the composite/elastomer hybrid structure is first analyzed by the finite element... 

Occurrence of natural disasters such as earthquake could seriously damage most buildings especially those with insufficient resistance located in urban worn-out textures. In order to reduce unpleasant consequences of an earthquake, appropriate policies need to be considered to persuade the beneficiaries to follow retrofitting standards in the process of planning, designing, and construction of buildings. These policies shall be implemented through institutions in arbitrary or obligatory forms, by encouragement or penalty mechanisms. In order to consider these policies, first of all we need to identify the beneficiaries and their particulars. By studying and considering subjects discussed in... 

Environmental issues and energy crisis have led the world attention to the renewable energies; especially wind power, since they have low cost and high reliability. One of the most challenging areas of studying for wind power is to increase the capacity of wind turbines. As a result, over the years, wind turbines have got progressively larger. Vibration is one of the problems that reduces the life and efficiency of wind turbines; and the growing size of the blades has worsen this problem due to the importance of nonlinear effects in large scale wind turbines. Researchers have been constantly working on this issue in order to make the wind turbines more efficient. In this research, a... 

Wind turbines have been the subject of many researches in recent decades. Optimization and continuous improvement of these systems play a decisive role in the development and exploitation of wind farms. Wind turbines can be studied from several aspects such as structure, dynamics, aerodynamics, electricity and control. In this research, robust power control of the wind turbine has been studied with emphasis on accurate 2 DOF mechanical and aerodynamic modeling. Aerodynamic coefficients of the turbine have been calculated using the numerical methods and the effect of this numerical modeling has been studied in comparison with the analytical methods on the turbine power control. Several new... 

In this research, the main purpose of the controller design is in the second region of operation of a wind turbine, which involves absorbing the maximum energy from the wind. WindPACT 1.5MW turbine has been investigated and the power coefficient of this turbine has been obtained using WT-PERF and FAST softwares. Simulations show that the results of both methods are well matched. Then, using ANFIS, a method for estimating the wind speed is derived from the data obtained by FAST. Inputs to the ANFIS system are the turbine aerodynamic power, rotor speed and blade pitch angle while the output of ANFIS system is the estimated wind speed. The maximum power coefficient of the wind turbine occurs... 

Best cancer treatment is the one which reduces the tumor density in minimum time and side effects, considering the input limitations. In this paper, tracking controller and robust controllers are designed to achieve the mentioned objectives, simultaneously. An ODE-based mathematical model of the human body under chemovirotherapy is selected, which includes the uninfected and infected tumor cells, free viruses, immune cells, and a chemotherapeutic drug. For tracking purposes, a servo controller based on the entire eigenstructure assignment (EESA) approach is applied to the model, continuously and discretely. For robust purposes H-infinity and D-K iteration approaches are implemented and... 

Laboratory studies to investigate the effects of different saline concentrations (such as sodium chloride or calcium chloride) on the soil water retention behavior of clayey soils and their volumetric changes have received much attention recently. However, many previous studies have investigated these effects in only one path of the SWRC (wetting or drying path) and the effects of saline concentration on hydraulic hysteresis have not been considered. In addition, researchers have frequently studied these effects on SWRC on clay samples, and little research has been done on collapsible soils. Therefore, the most important purpose of this study is to investigate the effects of increasing... 

Today, cancer mortality is one of the most important problems, even considering the scientific advances that offer more effective solutions to treat some diseases, providing a way to prevent and treat this disease is one of the most important issues that engineers have considered. This is achieved by designing a controller to minimize the size of the cancer tumor population, increase healthy cells, optimize treatment time, and drug dose.To achieve this goal, pharmacokinetic, pharmacodynamic, tumor growth, and healthy cell growth models, and mathematical models for subsystems that affect tumor growth, such as the angiogenic system, have been studied to develop a single mathematical model. In... 

This study proposes a probabilistic framework to quantify the seismic resilience of urban natural gas distribution networks. Infrastructure resilience is defined as the ability to maintain performance after a hazard or, in case of a loss of performance, return to the minimum desired level in the optimal time. The framework presented in this research is comprised of multiple interconnected probabilistic models. These models work in harmony to characterize the impact of the earthquake on various infrastructures such as the buildings and urban gas distribution network components, as well as the probable consequences of the earthquake. The post-earthquake recovery of the gas distribution network... 

Optimal use of available resources for construction projects depends on proper decision-making on how to spend resources. Optimization of resource consumption should be done taking into account project revenue. In this regard, investors need a suitable mechanism to predict the selling price of the construction project and the resulting profit. Therefore, investors and stakeholders need a suitable model with the help of which they can make decisions such as choosing materials to guarantee the desired profit from the sale. This research will provide a framework for constructing models for estimating the price of residential units by considering some features of the building and some economic... 

Understanding many issues related to environmental geotechnics and soil sciences such as: instability and collapse of soil slopes, sinkholes, leakage from landfills and isolation of nuclear landfills, and optimization Agricultural processing depends on our knowledge of the behavior of unsaturated soils and their volume changes. To better understand the behavior of unsaturated soils, it is important to study the soil-water retention curve (SWRC) and the factors affecting it. These include factors such as porosity, grain size distribution, soil minerals, pore size distribution, and pore water chemistry, which affect soil-water retention curves and volume changes. Since the simultaneous effect... 

Power transmission lines, which are responsible for the distribution and transmission of electrical energy from the power plant to the consumer areas, due to their characteristics such as long length and flexibility with low structural damping, face environmental irritations, especially the galloping phenomenon, causing many damages annually. In this study, it has been attempted to reduce the vibrations of power transmission lines by designing a robust active control and by using intermediate actuators in such a way that the failures of these lines can be prevented. For this purpose, linear modeling of the system and designing the controller using the pole replacement method have been done....