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    Design and Synthesis of a Drug Delivery System Based on Mesoporous Bioactive Glass

    , M.Sc. Thesis Sharif University of Technology Mirsafaie, Sahar Sadat (Author) ; Abdekhodaie, Mohammad Jafar (Supervisor)
    Abstract
    The aim of this research is to develop a smart mesoporous bioactive glass-based carrier for targeted drug delivery to cancer cells, particularly bone cancer cells. To achieve this, mesoporous bioactive glass nanoparticles were first synthesized, followed by surface modification with amine groups. To prevent premature drug release before reaching the target tissue and to introduce pH sensitivity, the nanoparticle pores were coated with oxidized hyaluronic acid via Schiff-base bonding with the amine groups on the surface. The use of hyaluronic acid facilitates active targeting of CD44 receptors, which are overexpressed on the surface of cancer cells compared to healthy cells. This process... 

    Electrodeposition of Pt nanostructures and its Application as Glucose Sensor

    , Ph.D. Dissertation Sharif University of Technology Mahshid, Sahar Sadat (Author) ; Dolati, Abolghasem (Supervisor) ; Ghorbani, Mohammad (Supervisor)
    Abstract
    The present work describes sensing application of modified Pt nanostructures towards detection of glucose. Modified Pt nanostructured electrodes were prepared using electrodeposition method such as chronoampermetry and potentiostatic pulse methods. The electrodeposition of Pt nanostructures was first studied by voltammetry and amperommetry techniques and then potentiostatic pulse method has been used to produce the alloyed structures of platinum. In this regard, the first electrode was proposed based on alloyed Pt/Ni nanowire arrays (NWAs) for the non-enzymatic detection of glucose. The Pt/Ni NWAs were prepared by pulse electrodeposition of Pt and Ni within a nano-pore polycarbonate (PC)... 

    Quantum Estimation of Open Systems Using Extended Cramer-Rao Bounds

    , M.Sc. Thesis Sharif University of Technology Mehboudi, Mohammad (Author) ; Rezakhani, Ali (Supervisor) ; Alipour, Sahar (Co-Advisor)
    Abstract
    Any physical system is characterized with some set of quantities or parameters, knowing which, is equivalent to estimation of the system. Evaluating such parameters is usually done using tomography methods. An important question to ask, is how to increase the precision of measurement, being able to do some specific set of physical operations, say, measurement?
    this question is more important in parameter estimation in quantum meanical systems. It has been shown that, quantum meanics causes a fundamental limit, on precision of estimating su parameters, escribed by the so called “antum Cramér-Rao bound”.We must note that almost all quantum meanical systems are interacting with the... 

    Selective Transfection of Smart Polymeric Nanoparticles Into Reactive Astrocytes in Animal Model of Spinal Cord Injury

    , Ph.D. Dissertation Sharif University of Technology Sabourian, Parinaz (Author) ; Frounchi, Masoud (Supervisor) ; Mashayekhan, Shohreh (Co-Supervisor) ; Kiani, Sahar (Co-Supervisor)
    Abstract
    In this study, chitosan-based nanoparticles were prepared due to their biocompatibility, availability, high loading capacity of drug, stimulus responsive behavior and the presence of active functional groups. Chitosan was chemically functionalized with reactive oxygen species (ROS)-responsive moiety to respond to the oxidative stess and endosomal pH in nerve injuries. To prepare nanoparticles, functinalized chitosan ionically gelated with pH-responsive polyanions with ROS-scavenging properties such as polyacrylic acid and hyaluronic acid. Then, pH- and ROS-responsive nanoparticles were used for selective transfection into reactive astrocytes and axonal regeneration in spinal cord injuries.... 

    Nanogold imprinted starch bionanocomposites for food packaging applications

    , Article Starch Based Nanomaterials for Food Packaging: Perspectives and Future Prospectus ; 2023 , Pages 209-226 ; 978-044318967-8 (ISBN); 978-044318968-5 (ISBN) Tariq, T ; Saleem, I. M ; Sahar, A ; Raza, N ; Sameen, A ; Nayik, G. A ; Ramniwas, S ; Sharif University of Technology
    Elsevier  2023
    Abstract
    Food science researchers are concerned about global food wastage due to decreased shelf life. It has been shown that using approaches based on nanotechnology, including metal-based nanoparticles (NPs), can alleviate the issues with decreased shelf life and environmental problems. Gold nanoparticles (AuNPs) and their synthesis have seen notable advancements in the last several decades. AuNPs are now utilised more often in industrial and medicinal settings. AuNPs are being employed in the nanopackaging industry as a recently adopted technique because of their medicinal and antibacterial properties and their inert and hypoallergenic nature. When employed in the food industry, AuNPs have... 

    Gapless chiral excitons in thin films of topological insulators

    , Article EPL ; Vol. 107, issue. 2 , 2014 ; ISSN: 02955075 Jafari, S. A ; Sharif University of Technology
    2014
    Abstract
    In a nanoscopic thin film of a strong topological insulator (TI) the Coulomb interaction in the channel that exchanges the two electrons with the same chirality in two different planes of the slab takes advantage of the minus sign resulting from such "exchange" and gives rise to a bound state between the positive-energy states in one surface and the negative-energy states in the opposite surface. Therefore particle and hole pairs in the undoped Dirac cone of the TI thin film form an inter-surface spin-singlet state that lies below the continuum of free particle-hole pairs. This mode is similar to the excitons of semiconductors, albeit formed between the electron and hole pairs from two... 

    Collective excitations and the nature of Mott transition in undoped gapped graphene

    , Article Journal of Physics Condensed Matter ; Volume 24, Issue 30 , 2012 ; 09538984 (ISSN) Jafari, S. A ; Sharif University of Technology
    2012
    Abstract
    The particle-hole continuum (PHC) for massive Dirac fermions provides an unprecedented opportunity for the formation of two collective split-off states, one in the singlet and the other in the triplet (spin-1) channel, when the short-range interactions are added to the undoped system. Both states are close in energy and are separated from the continuum of free particle-hole excitations by an energy scale of the order of the gap parameter Δ. They both disperse linearly with two different velocities, reminiscent of spin-charge separation in Luttinger liquids. When the strength of Hubbard interactions is stronger than a critical value, the velocity of singlet excitation, which we interpret as a... 

    Nonlinear optical response in gapped graphene

    , Article Journal of Physics Condensed Matter ; Volume 24, Issue 20 , 2012 ; 09538984 (ISSN) Jafari, S. A ; Sharif University of Technology
    2012
    Abstract
    We present a formulation for the nonlinear optical response in gapped graphene, where the low-energy single-particle spectrum is modeled by massive Dirac theory. As a representative example of the formulation presented here, we obtain a closed form formula for the third harmonic generation in gapped graphene. It turns out that the covariant form of the low-energy theory gives rise to peculiar logarithmic singularities in the nonlinear optical spectra. The universal functional dependence of the response function on dimensionless quantities indicates that the optical nonlinearity can be largely enhanced by tuning the gap to smaller values  

    Exact phase boundaries and topological phase transitions of the XYZ spin chain

    , Article Physical Review E ; Volume 96, Issue 1 , 2017 ; 24700045 (ISSN) Jafari, S. A ; Sharif University of Technology
    2017
    Abstract
    Within the block spin renormalization group, we give a very simple derivation of the exact phase boundaries of the XYZ spin chain. First, we identify the Ising order along ◯ or ŷ as attractive renormalization group fixed points of the Kitaev chain. Then, in a global phase space composed of the anisotropy λ of the XY interaction and the coupling Δ of the Δσzσz interaction, we find that the above fixed points remain attractive in the two-dimesional parameter space. We therefore classify the gapped phases of the XYZ spin chain as: (1) either attracted to the Ising limit of the Kitaev-chain, which in turn is characterized by winding number ±1, depending on whether the Ising order parameter is... 

    Electric field assisted amplification of magnetic fields in tilted Dirac cone systems

    , Article Physical Review B ; Volume 100, Issue 4 , 2019 ; 24699950 (ISSN) Jafari, S. A ; Sharif University of Technology
    American Physical Society  2019
    Abstract
    We show that the continuum limit of the tilted Dirac cone in materials such as 8-Pmmn borophene and layered organic conductor α-(BEDT-TTF)2I3 corresponds to deformation of the Minkowski space-time of Dirac materials. From its Killing vectors we construct an emergent tilted-Lorentz (t-Lorentz) symmetry group for such systems. As an example of the t-Lorentz transformations we obtain the exact solution of the Landau bands for a crossed configuration of electric and magnetic fields. For any given tilt parameter 0≤ζ<1, if the ratio χ=vFBz/Ey of the crossed magnetic and electric fields satisfies χ≥1+ζ, one can always find appropriate t-boosts in both valleys labeled by τ=±1 in such a way that the... 

    Tilted-Lorentz symmetry

    , Article Iranian Journal of Physics Research ; Volume 19, Issue 4 , Winter , 2020 , Pages 831-834 Jafari, S. A ; Sharif University of Technology
    Isfahan University of Technology  2020
    Abstract
    Dirac cone can be tilted in condensed matter setting. As a result of tilt, the Lorentz symmetry is reduced to what we call tilted-Lorentz symmetry. In this paper, we derive the tilted-Lorentz transformations that leave a world with tilted Dirac cone invariant. © 2020, Isfahan University of Technology. All rights reserved  

    Mitigating DDoS Using BOTNET Analysis with Flow Anomaly Detection

    , M.Sc. Thesis Sharif University of Technology Baradaran Jafari, Navid (Author) ; Jafari, Mahdi (Supervisor) ; Endicott-Popovsky, Barbara (Co-Advisor)
    Abstract
    Internet is the largest multi-purpose, self-reliant, complex and distributed computer network across the globe. The nodes of this network are placed in every place like homes, offices, military camps, schools and all other locations by utilizing many different communication protocols, media and capacities. Furthermore, by rapid technology development, there are many newly born applications utilizing internet in new ways such as Internet of Things systems. The explosive growth of technology causing accelerated addition of new nodes to the internet, and any new single node may have several new unpatched vulnerabilities. This is a serious issue for managing this vast chaotic configuration and... 

    Analysis and simulation of ring resonator silicon electro-optic modulators based on PN junction in reverse bias

    , Article Optical Engineering ; Vol. 53, issue. 12 , 2014 ; ISSN: 00913286 Jafari, O ; Akbari, M ; Sharif University of Technology
    2014
    Abstract
    The theory of silicon optical modulators of ring resonators based on PN diode in reverse bias is primarily discussed. It secondarily provides a full-featured simulator to investigate the behavior of such modulators. Wave equation for ring structure will be solved by using the conformal transformation method and the matrix method as it was used to analyze bent planar optical waveguides. Power coupling between ring and straight waveguides will be calculated by coupled theory of nonparallel waveguides based on experimental results. The time response demonstrates the capability of this device to operate correctly at up to 10 Gbs-1 bitrate, and the frequency spectrum analysis of device shows a >... 

    Neural network-based brain tissue segmentation in MR images using extracted features from intraframe coding in H.264

    , Article Proceedings of SPIE - The International Society for Optical Engineering, 9 December 2011 through 10 December 2011, Singapore ; Volume 8349 , December , 2012 ; 0277786X (ISSN) ; 9780819490254 (ISBN) Jafari, M ; Kasaei, S ; Sharif University of Technology
    2012
    Abstract
    Automatic brain tissue segmentation is a crucial task in diagnosis and treatment of medical images. This paper presents a new algorithm to segment different brain tissues, such as white matter (WM), gray matter (GM), cerebral spinal fluid (CSF), background (BKG), and tumor tissues. The proposed technique uses the modified intraframe coding yielded from H.264/(AVC), for feature extraction. Extracted features are then imposed to an artificial back propagation neural network (BPN) classifier to assign each block to its appropriate class. Since the newest coding standard, H.264/AVC, has the highest compression ratio, it decreases the dimension of extracted features and thus yields to a more... 

    Automatic brain tissue detection in MRI images using seeded region growing segmentation and neural network classification

    , Article Australian Journal of Basic and Applied Sciences ; Volume 5, Issue 8 , 2011 , Pages 1066-1079 ; 19918178 (ISSN) Jafari, M ; Kasaei, S ; Sharif University of Technology
    2011
    Abstract
    This paper presents a neural network-based method for automatic classification of magnetic resonance images (MRI) of brain under three categories of normal, lesion benign, and malignant. The proposed technique consists of six subsequent stages; namely, preprocessing, seeded region growing segmentation, connected component labeling (CCL), feature extraction, feature Dimension Reduction, and classification. In the preprocessing stage, the enhancement and restoration techniques are used to provide a more appropriate image for the subsequent automated stages. In the second stage, the seeded region growing segmentation is used for partitioning the image into meaningful regions. In the third... 

    Microstructure generation of severely deformed materials using Voronoi diagram in Laguerre geometry: Full algorithm

    , Article Computational Materials Science ; Volume 50, Issue 9 , July , 2011 , Pages 2698-2705 ; 09270256 (ISSN) Jafari, R ; Kazeminezhad, M ; Sharif University of Technology
    2011
    Abstract
    A new Voronoi diagram in Laguerre geometry based on closed-pack non-overlapping circles was proposed. This diagram was used to simulate microstructure of severely deformed materials at different applied strains. Grains size and their fractions were introduced by controlling the size and distribution of nuclei. Edge number distribution and neighboring cells edge number along with area distribution of the simulated Voronoi cells were determined. The edge number distribution was observed to fit gamma distribution more accurately. However, due to high inhomogeneity in the microstructure of the deformed samples at low strains, edge number distribution could not be matched by any distribution... 

    Three-qubits ground state and thermal entanglement of anisotropic Heisenberg (XXZ) and Ising models with Dzyaloshinskii-Moriya interaction

    , Article International Journal of Quantum Information ; Volume 9, Issue 4 , 2011 , Pages 1057-1079 ; 02197499 (ISSN) Jafari, R ; Langari, A ; Sharif University of Technology
    2011
    Abstract
    We have studied the symmetric and non-symmetric pairwise ground state and thermal entanglement in three-qubits system. We have considered the anisotropic Heisenberg (XXZ) model in the presence of DzyaloshinskiiMoriya (DM) interaction in addition to the Ising model in a magnetic field with DM interaction. We have found that the increment of DM interaction and magnetic field can enhance and reduce the entanglement of the system. We have shown that the non-symmetric pairwise state has higher value concurrence and critical temperature (above which the entanglement vanishes) than the symmetric pairwise one. For the negative anisotropy, the non-symmetric entanglement is a monotonic function of DM... 

    Fibre position effects on the operation of opto-pair fibre displacement sensors

    , Article Optics and Laser Technology ; Volume 43, Issue 4 , 2011 , Pages 814-819 ; 00303992 (ISSN) Jafari, R ; Golnabi, H ; Sharif University of Technology
    2011
    Abstract
    In this article, two optical-fibre probes used in displacement measurements are reported. In one arrangement, two optical fibres with protective buffer jackets are placed together, while in the second arrangement, the protective buffer jackets are removed and the two fibres are placed with the claddings in contact, with a concomitant smaller centrecentre distance. As the core and cladding diameters are the same in both probes, the effect of the centrecentre distance on double-fibre designs can be investigated. The reflected output powers are recorded for the probes as a function of the axial distance from a reflective surface. A theoretical model is also implemented, which considers the... 

    Fast intra- and inter-prediction mode decision of H.264/AVC for medical frame compression based on region of interest

    , Article Australian Journal of Basic and Applied Sciences ; Volume 5, Issue 5 , 2011 , Pages 397-411 ; 19918178 (ISSN) Jafari, M ; Kasaei, S ; Sharif University of Technology
    2011
    Abstract
    This paper aims at applying H.264/AVC in medical video compression applications and improving its compression performance with higher perceptual quality and lower coding complexity. We propose a new method that uses lossless compression in the region of interest (ROI) and very high rate lossy compression in other regions. The propose method achieves a fast intra- and interprediction mode decision that is based on encountering coarse MBs for intra- and inter- prediction mode decision of the background region and fine MBs for the ROI region. The MBs of the background region are encoded with the maximum quantization parameter allowed by H.264/AVC in order to maximize the number of null... 

    Simulation of three different double-fiber probes for reflection sensing

    , Article Journal of Applied Sciences ; Volume 10, Issue 1 , 2010 , Pages 20-28 ; 18125654 (ISSN) Jafari, R ; Golnabi, H ; Sharif University of Technology
    2010
    Abstract
    In this study simulation results for three double-fiber optical designs for the reflection measurements are reported. Modeling is perused for three cases namely Equal Fibers (EF), transmitter fiber shorter (TS) and receiver fiber shorter (RS) designs. By proper modeling and written programs the operations of such symmetric double-fiber probes are simulated and the role of different crucial parameters such as fiber-to-fiber distance (t), fiber core radius (r) and fiber Numerical Aperture (NA) are investigated. In the second study simulation results for the transmitter fiber shorter and receiver fiber shorter designs are investigated for different fiber length differences (w). Finally...