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Casing Collapse Analysis in Kupal Field
, M.Sc. Thesis Sharif University of Technology ; Shad, Said (Supervisor) ; Jamshidi, Said (Supervisor)
Abstract
Casing collapse is a long-standing problem in Kopal oil field, located at a distance of 60 km of east of Ahwaz, Iran. In this field, so far casing collapse has encountered in 18 well-bore out of the 56 drilled-well-bore (~32%) due to creep loading caused by salt flow, which resulted in tremendous economic loss. Among all the different set of factors leading to such a problem, the effects of the local stress distribution on the wellbore wall and casing (resulted from the in-situ stresses, and stress perturbation due to drilling), pore pressure, the casing quality and material, and the applied-cement type are important. In order to investigate these factors and their effects, they should be...
Design a Microfluidics System for Drug Testing of Leukemia Patient's Bone Marrow Aspirate
, M.Sc. Thesis Sharif University of Technology ; Saidi, Mohammad Said (Supervisor)
Abstract
Cancer is one of the most causes of mortality in the world. Leukemia is a type of cancer initiated by the rapid proliferation of blood cells including WBCs, RBCs, and Platelets, that classified into four general types of AML, ALL, CML, and CLL. The main treatment of leukemia is chemotherapy. Because of many problems that patients have with this treatment and not so good results of chemotherapy, we design a microfluidic chip that can perform personalized medicine treatment for leukemia patients.This microchip consists of two main parts, Concentration Gradient Generator (CGG), and cell culture. CGG system is a tree CGG with two inlets and four outlets, which makes a linear concentration of...
Numerical Simulation of Shaking Bioreactors for Cell Culture
,
M.Sc. Thesis
Sharif University of Technology
;
Saidi, Mohammad Said
(Supervisor)
Abstract
A bioreactor can refer to any device or system constructed on engineering basis and has an active biological medium. This medium includes aerobic and non-aerobic reactions in which organisms and the theire produced substances have the main role. One of the applications of bioreactors is to provide an appropriate medium for animal and plant cell culture and growth. Nowadays many biological processes in high volume scales are carried out in stirred tank bioreactors. In these bioreactors oxygen transfer is usually increased by increasing turbulence which is necessary for mixing nutrients and keeping the homogeneity of the medium. However, there are some limitations for increasing the stirring...
Performance analysis of spectral-phase-encoded optical CDMA system using two-photon-absorption receiver structure for asynchronous and slot-level synchronous transmitters
, Article Journal of Lightwave Technology ; 2007, Volume 25, Issue 6, Pages 1638-1645 ; Salehi, J. A ; Sharif University Of Technology
Abstract
In this paper, we analyze the performance of a nonlinear two-photon-absorption (TPA) receiver and compare its performance with that of a single-photon-absorption (SPA) receiver in the context of spectral-phase-encoded optical code-division multiple access (CDMA) technique. The performances for the above systems are evaluated for two different transmission scenarios, namely, asynchronous and slot-level synchronous transmitters. Performance evaluation includes different sources of degradation such as multiple-access interference, noise due to optical amplification, shot noise, and thermal noise. In obtaining the performance, the mean and variance of the received signal in each of the above...
Statistical characterization and the bit- error- rate analysis of lightwave systems with optical amplification using two-photon absorption receiver structures
, Article IEEE/OSA Journal of Lightwave Technology ; 2006 Vol. 24, Issue 3, PP. 1302-1316 ; Salehi, J. A ; Sharif University Of Technology
Abstract
In this paper, the authors study the performance of a two-photon absorption (TPA) receiver in a typical communication system employing an optical amplifier. For the study, the authors develop a comprehensive performance analysis, taking into account noises due to an optical amplifier, shot noise, and thermal noise, using Gaussian approximation technique. In evaluating the performance of the system using this technique, the mean and the variance of the received signal will be derived. Comparing the results of receivers using the TPA process with that of a typical single-photon absorption (SPA) structure leads the authors to conclude that TPA receivers can be used when the speed of the...
Statistical analysis of coherent ultrashort light pulse CDMA with multiple optical amplifiers using additive noise model
, Article IEEE/OSA Journal of Lightwave Technology ; Vol. 23, No. 5, PP. 1842-1851, May 2005 ; Salehi, J. A ; Sharif University Of Technology
Abstract
This paper describes a study of the performance of various configurations for placing multiple optical amplifiers in a typical coherent ultrashort light pulse code-division multiple access (CULP-CDMA) communication system using the additive noise model. For this study, a comprehensive performance analysis was developed that takes into account multiple-access noise, noise due to optical amplifiers, and thermal noise using the saddle-point approximation technique. Prior to obtaining the overall system performance, the input/output statistical models for different elements of the system such as encoders/decoders, star coupler, and optical amplifiers were obtained. Performance comparisons...
Design, Numerical Flow Simulation and Construction Feasibility Study of Light Scattering Aerosol Spectrometer
, M.Sc. Thesis Sharif University of Technology ; Saidi, Mohammad Said (Supervisor)
Abstract
Aerosols are significant two-phase systems that have an important effect on environmental, biological, health, industrial and other scientific and engineering fields. According to chief aerosol effects, various instruments namely “Aerosol Spectrometer” have been developed to measure aerosols. Optical Particle Counters (OPCs) are one of this instruments that can count and measure the particles size distribution in the aerosols.
In the current project, an optical particle counter has been designed. For validating the correct operation of the designed plan, it is needed to simulate the instrument optically and mechanically, so the Mie theory was used to simulate the intensity of the...
In the current project, an optical particle counter has been designed. For validating the correct operation of the designed plan, it is needed to simulate the instrument optically and mechanically, so the Mie theory was used to simulate the intensity of the...
Numerical Simulation and Analysis of Electrokinetic Micromixer
, M.Sc. Thesis Sharif University of Technology ; Saidi, Mohammad Said (Supervisor)
Abstract
Lab-On-A-Chip is a micro-scale system which utilizes specific tools in order to operate detection tests on samples. One of the most important components of these devices is micromixers which is responsible for appropriate mixing of samples in short period of time. The biggest problem associated to the mixing in micro-scale is the regime that the flow takes during the process. Due to the small dimensions of micromixers the induced flow stream resides in the range of laminar flows and consequently the mixing is conducted solely by diffusion mechanism which is either time-taking or requires long micro-channel that causes the high cost of fabrication. In order to improve the mixing process two...
Behaviour of columns made from high strength steel
, Article World Congress on Engineering 2016, WCE 2016, 29 June 2016 through 1 July 2016 ; Volume 2224 , 2016 , Pages 1184-1187 ; 20780958 (ISSN); 9789881404800 (ISBN) ; Kamalarajah, R ; Cashell, K. A ; Chizari, M ; Sharif University of Technology
Newswood Limited
2016
Abstract
The buckling behaviour of compression members is very important in structural engineering especially those that are made from high strength steel (HSS). This paper presents an investigation into the behaviour of four columns which were designed according to EN 1993-1-1 (2005) so that the buckling capacity of both HSS and mild steel column was equal. A finite element model was created which included imperfections due to residual stresses as well as local and global imperfections. It was found that the buckling capacity of the columns made from 460 MPa steel was lower than that for similar capacity mild steel columns with a yield strength of 275 MPa. Accordingly, a buckling curve for HSS is...
A conceptual structure for value based assessment of dynamic reactive power support in power markets
, Article Electric Power Systems Research ; Volume 77, Issue 7 , 2007 , Pages 761-770 ; 03787796 (ISSN) ; Vakilian, M ; Feuillet, R ; Hadj Said, N ; Sharif University of Technology
2007
Abstract
This paper presents a practical reactive power valuation method, for the purpose of the reactive power pricing, in which the VAr value is decomposed into two components. These components are basically different from those already employed in the literature. Using a security constrained optimization model, the proposed scheme allocates two specific amounts of MW transactions to each generator as a dynamic reactive power source. One of these allocated amounts represents the contribution of the VAr resource to the shipment of active power, while the other one represents the contribution to the protection of the system against voltage instability. The final VAr value is derived using the...
Valuation of dynamic reactive power support in multitransaction power systems
, Article European Transactions on Electrical Power ; Volume 17, Issue 1 , 2007 , Pages 61-79 ; 1430144X (ISSN) ; Vakilian, M ; Feuillet, R ; Hadj Said, N ; Sharif University of Technology
2007
Abstract
This paper presents a reactive power valuation method with regard to its effect on realization of MW transactions. The security constraint optimization model in which the objective function is maximization of transactions is solved by the genetic algorithm approach. The proposed scheme allocates a specific amount of MW transactions to each dynamic reactive power source. An index is introduced to derive VAr value from the calculated optimal parameters of power network. This index represents the system-wide effect of MVAr sources on MW transactions implementations. Application of proposed method has been illustrated using IEEE 30 and 14 bus test systems. Results are discussed and compared in...
Simulation of Dynamic Behavior of Endothelial Cell During Compression Test
, M.Sc. Thesis Sharif University of Technology ; Saidi, Mohammad Said (Supervisor) ; Firoozabadi, Bahar (Supervisor)
Abstract
Investigation of the behavior of living cells in different biological conditions could play a key role in exploring the main reasons of humans' disorders and diseases. In this regard, many researchers are studying different subjects related to the living cells. Although most of these research activities are based on experimental methods, numerical approach could be utilized to investigate some topics which cannot be studied by experimental methods.In this study a three dimensional model of endothelial cell is proposed for the investigation of cell performance during compression test. The model consists of cell membrane, nucleus and main components of cytoskeleton, namely actin filaments,...
Heat transfer improvement in a thermal energy storage system using auxiliary fluid instead of nano-pcm in an inclined enclosure: a comparative study
, Article Journal of Applied and Computational Mechanics ; Volume 9, Issue 2 , 2023 , Pages 475-486 ; 23834536 (ISSN) ; Abtahi Mehrjardi , A ; Said, Z ; Chamkha, A. J ; Sharif University of Technology
Shahid Chamran University of Ahvaz
2023
Abstract
Modern thermal energy storage (TES) systems rely laboriously on finding a low-cost method to improve heat transfer. In the present analysis, adding CuO nanoparticles and tilting the enclosure simultaneously is compared with a novel approach that employed water as a supplemental fluid to improve the melting process using the density difference between PCM and supplemental fluid. Oleic acid is selected as an immiscible PCM in water, which causes PCM and auxiliary fluid utterly separate at the end of the melting process to be usable in more additional TES cycles. By placing water as a heavier material directly on top of oleic acid, the melted oleic acid is replaced by water at the bottom of the...
Modeling, Simulation and Characterization of Pressurized Reservoir Insulin Pump
, M.Sc. Thesis Sharif University of Technology ; Saidi, Mohammad Said (Supervisor) ; Sani, Mahdi (Supervisor)
Abstract
Insulin pump treatment is considered the most physiological way to imitate the healthy body's insulin profile in patients with diabetes. They provide a precisely controlled rate of insulin delivery to diabetic patients who would normally need multiple daily injections to regulate blood glucose levels. The firmware allows numerous modifications to the bolus dose and basal rate to enable patients to manage insulin levels in response to events such as eating, sleeping, and exercise.
In this Study, we have first investigated different models of insulin pumps on the market and chose the Spring ZoneTM insulin pump model for our study due to its innovative technology. This pump employs a...
In this Study, we have first investigated different models of insulin pumps on the market and chose the Spring ZoneTM insulin pump model for our study due to its innovative technology. This pump employs a...
Completely 3dimensional Simulation of Urine Concentrating Mechanism in Rat Outer Medulla
, M.Sc. Thesis Sharif University of Technology ; Saidi, Mohammad Said (Supervisor) ; Firoozabadi, Bahar (Co-Advisor)
Abstract
The urine formation and excretion system has long been of interest for mathematicians and physiologists to elucidate the obscurities within the process happen in renal tissue. In this study, a novel and absolutely three-dimensional approach is utilized for modeling urine concentrating mechanism in rat renal outer medulla which is essentially focused on demonstrating the significance of tubule's architecture revealed in anatomic studies and physiological literature. Since nephrons and vasculatures work interdependently through a highly structured arrangement in outer medulla which is dominated by vascular bundles, a highly detailed functional unit is proposed and also it is strongly justified...
Cancer Cell Separation Using Spiral Microchannel
, M.Sc. Thesis Sharif University of Technology ; Saidi, Mohmmad Said (Supervisor) ; Firoozbakhsh, Keykhosrow (Supervisor)
Abstract
Particle separation has a variety of applications in biology, chemistry and industry. Among them, circulating tumor cells (CTCs) separation has drawn significant attention to itself due to its high impact on both cancer diagnosis and therapeutics. In recent years, there has been growing interest in using inertial microfluidics to separate micro/nano particles based on their sizes. This technique offers label-free, high throughput, and efficient separation and can be easily fabricated. However, further improvements are needed for potential clinical applications. In this study, a novel inertial separation technique using spiral microchannel with stair-like cross section is introduced. The...
Numerical Simulation of Micro channel for Cells Counting Based on the Impedance Measurement of Cell Lysate
, M.Sc. Thesis Sharif University of Technology ; Saidi, Mohammad Said (Supervisor) ; Sani, Mahdi ($item.subfieldsMap.e)
Abstract
Nowadays cell-based microfluidic devices have many applications. One of the applications is disease diagnosis according to number of cells. Cell counting has different methods, such as optical cell counting, flow cytometry, hemocytometry, coulter counters,and so on. One of the methods of cells counting is based on measurement of changes in impedance or conductivity of surrounding medium because ions are released from surface-immobilized cells inside a micr of luidic channel.The method of cell lysate impedance spectroscopy is sensitive enough and it was offered for detecting and enumerating CD4+ cells in HIV patients. In this study,...
Filtration Based on Electrostatic Devices
, M.Sc. Thesis Sharif University of Technology ; Saidi, Mohammad Said (Supervisor) ; Sani, Mahdi (Supervisor)
Abstract
Particulate air pollution is one of the top environmental health risks. Industrial processes like power generation from fossil fuels and steel and cement manufacturing release a huge amount of particles into the atmosphere. Moreover, internal combustion engines produce a considerable amount of particulate matter in populated areas. The usual way to overcome this risk is using air-cleaning devices such as filters. Filters are designed for specific purposes like removing aerosol particles, aerosol sampling and collecting valuable particles. Because of its diverse applications, filtration has become an active area of research and many kinds of filters are currently available. One type of...
Separation and Microfluidic Analysis of one Cancer Biomarker (Exosome) by Means of Microfluidic Chip Microfluidc Analysis Exosome Toward Liquid Biopsy for Cancer Tumor Cell
, M.Sc. Thesis Sharif University of Technology ; Saidi, Mohammad Said (Supervisor) ; Firouzabadi, Bahar (Co-Supervisor)
Abstract
The recent breakthroughs in the lab-on-a-chip technology will not be directly used as clinical devices unless the specific applications are carefully tested and certified. As there is a growing trend towards microfluidic devices for biomedical research, an active microfluidic device was developed. Common microfabrication methods were used to develop a microchip to separate and concentrate exosome and particular cell based on the dielectrophoresis phenomenon. Unique capabilities of the dielectrophoresis phenomenon make it a powerful tool for micro particle manipulation in micro scale. In this research, geometry for the mentioned purpose is designed and optimized. Three-dimensional...
Completing the Fabrication of Magnetic Micro-swimmer Positioning System and Designing an Optimal Controller to Minimize Energy Consumption
, M.Sc. Thesis Sharif University of Technology ; Nejat, Hossein (Supervisor) ; Saidi, Mohammad Said (Co-Supervisor)
Abstract
Micro-Robotics is implemented by researchers inclusively in last decades in different fields such as, biolotechnology, space, army and medical engineering. However, micropositioning is the main challenge in such projects, since determination and control of micro-robot’s position for drug delivery, artificial insemination and other medical applications are too significant. In this thesis, a method for controlling a microswimmer’s position in two dimention by an external magnetic field has been proposed. Modelling of magnetic field and magnetic gradient are some important challenges due to the fact that in control loop, a fast and optimal model for estimation of magnetic filed and gradient is...