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Molecular mechanism of glycosylated IL-1RII counteraction with IL-1RI in regulation of the immune response
, Article Molecular Simulation ; Volume 49, Issue 16 , 2023 , Pages 1491-1501 ; 08927022 (ISSN) ; Azimzadeh Irani, M ; Ejtehadi, M. R ; Sharif University of Technology
Taylor and Francis Ltd
2023
Abstract
Interleukin-1 Receptor Type II (IL-1RII) is the decoy receptor of IL-1 cytokines. It down-regulates the immune signalling pathways. There is a competitive behaviour between the IL-1RII and IL-1RI, which is the signalling receptor of the IL-1Rs family. By adopting similarities in structure and specific shared ligands, the two receptors are competing regulators of the immune response. Conformational changes of IL-1RII is a crucial factor in its ligand binding and activation. In addition, dynamics and functionality of the receptor are known to be regulated by glycosylation. Herein, all-atom Molecular Dynamics (MD) simulations were carried out to investigate the dynamics of the apo and...
Band-gap narrowing and electrochemical properties in N-doped and reduced anodic TiO2 nanotube arrays
, Article Electrochimica Acta ; Volume 270 , 2018 , Pages 245-255 ; 00134686 (ISSN) ; Khameneh Asl, S ; Mohammadpour, R ; Khameneh Asl, S ; Sharif University of Technology
Elsevier Ltd
2018
Abstract
Electrochemical activity of TiO2 nanotube arrays (NTAs) is restricted by a wide band gap of TiO2. To overcome this restriction, we considered systematic research on two effective methods of doping of TiO2 NTAs such as the N-doping and electrochemical reductive doping and predicting the proper application of them. Band gap narrowing was occurred from 3.16 eV for undoped TiO2 NTAs to 2.9 and 2.7 eV at N-doped and self-doped TiO2 ones respectively. The electrochemical responses of the TiO2 NTAs before and after doping were examined by cyclic Voltammetry (CV) curve. To understand the electrochemical behavior of the undoped and doped TiO2 NTAs, electrochemical impedance spectroscopy (EIS) was...
Improved efficiency in front-side illuminated dye sensitized solar cells based on free-standing one-dimensional TiO2 nanotube array electrodes
, Article Solar Energy ; Volume 184 , 2019 , Pages 115-126 ; 0038092X (ISSN) ; Khameneh Asl, S ; Mohammadpour, R ; Khameneh Asl, S ; Sharif University of Technology
Elsevier Ltd
2019
Abstract
Although morphological disorder of nanotube structure is further down than the nanoparticular electrode, its density of traps are the hindering effects in the charge transport. In this study, crack-free TiO2 nanotube membranes, which obtained through a re-anodizing process, are fixed on transparent fluorine–tin-oxide glass by applying a few drops of Titanium Isopropoxide without needing the TiO2 powder paste. Front-side illuminated dye sensitized solar cells fabricated by undoped, N-doped and blue TiO2 nanotube membranes are investigated. The electrical characteristics of TiO2 nanotube based dye sensitized solar cells are followed by theoretical analysis using simple one-diode model....
Influence of scalar-relativistic and spin-orbit terms on the plasmonic properties of pure and silver-doped gold chains
, Article Journal of Physical Chemistry C ; Volume 123, Issue 14 , 2019 , Pages 9331-9342 ; 19327447 (ISSN) ; Asadi Aghbolaghi, N ; Jamshidi, Z ; Sharif University of Technology
American Chemical Society
2019
Abstract
The unique plasmonic character of silver and gold nanoparticles has a wide range of applications, and tailoring this property by changing electronic and geometric structures has received a great deal of attention. Herein, we study the role of the quantum properties in controlling the plasmonic excitations of gold and silver atomic chains and rods. The influence of relativistic effects, scalar as well as spin-orbit, on the intensity and energy of plasmonic excitations is investigated. The intensity quenching and the red shift of energy in the presence of relativistic effects are introduced via the appearance of d orbitals directly in optical excitations in addition to the screening of...
EPFC-Based Methodology-Engineering Method and Environment for Enhancing the Automatic Assembly of Method Fragments
, M.Sc. Thesis Sharif University of Technology ; Ramsin, Raman (Supervisor)
Abstract
Selection of development methodologies according to the specifications of software development projects continues to be an important challenge for the software industry. Despite the growth of software methodologies, this problem has not been fully resolved yet. Software engineers have realized, however, that there is no general-purpose methodology which is suitable for all situations. Therefore, the necessity of Situational Method Engineering (SME) has become apparent, and engineers have started to use different methods for engineering software processes to fit the project situation at hand. Assembly-based, Extension-based and Paradigm-based approaches are the SME methods prevalently used...
Development of an Energy Management Technique for Automata-Based Embedded Systems
, M.Sc. Thesis Sharif University of Technology ; Ejlali, Alireza (Supervisor)
Abstract
Event-based embedded systems are usually energy-constrained and also have to be highly reliable. This thesis presents a novel energy-efficient standby-sparing technique for eventbased embedded systems. It speculatively pre-executes reaction tasks prior to events, resulting in a high available slack time for energy management. Although the prediction might be wrong, we will show that in average the proposed speculative standby-sparing technique (SSS) consumes less energy compared to non-speculative techniques. We present some real-life examples of event-based embedded systems to justify practical use for the proposed technique. To evaluate SSS extensive experiments were conducted on a variety...
Improving Efficiency of Storage Subsystems for Virtualized Platforms
, Ph.D. Dissertation Sharif University of Technology ; Asadi, Hossein (Supervisor)
Abstract
In recent years, high interest in using virtualization platforms and Virtual Machines (VMs) in enterprise data centers and Clouds has significantly increased the demand for high performance data storage systems. Recent studies in virtualized platforms have suggested using high-performance storage elements such as Solid-State Drives (SSDs) as a caching layer for storage subsystems mainly built upon Hard Disk Drives (HDDs). Such studies implicitly focus on sharing and partitioning the I/O cache space between VMs, while they neglect to address other important parameters such as SSD lifetime, reliability, and cache policies, which can significantly affect the efficiency of I/O caching in terms...
Investigation of the Effect of Nanosilica Surface Modification on Crystalline Microstructure and Rheological and Mechanical Properties of High Density Polyethylene (HDPE)
, M.Sc. Thesis Sharif University of Technology ; Pircheraghi, Gholamreza (Supervisor)
Abstract
A high flexural modulus and high elasticity are essential for corrugated pipes used for underground wastewater transportation. High density polyethylene (HDPE), a semi-crystalline polymer, is commonly used for the production of these pipes. In this study, a nanocomposite approach was used in which recycled nano-silica from lead-acid battery separators was incorporated in weight fractions of 1%, 3% and 5% to increase the modulus. To improve the dispersion of the nano-silica particles in the polymer matrix and thus the mechanical properties, the nano-silica particles were surface modified with 3-aminopropyltriethoxysilane as coupling agent together with a maleic anhydride grafted HDPE...
Comparison of spinal stability following motor control and general exercises in nonspecific chronic low back pain patients
, Article Clinical Biomechanics ; Volume 48 , 2017 , Pages 42-48 ; 02680033 (ISSN) ; Sarrafzadeh, J ; Jamshidi, A ; Arjmand, N ; Ghezelbash, F ; Sharif University of Technology
2017
Abstract
Background Motor control exercise was claimed to improve spinal stability in patients with chronic non-specific back pain, but to investigate the effectiveness of this exercise, other outcome measures have been used rather than spinal stability itself. The aim of our study is to assess motor control exercise effects on spinal stability using a biomechanical model. Methods Fifty-one patients were assigned to either motor control or general exercises. Before and after trainings, participants were tested for spinal stability at seven isometric tasks. Electromyography signals were recorded from ten superficial muscles, and a hybrid EMG-driven musculoskeletal model estimated spinal stability...
Dynamically adaptive register file architecture for energy reduction in embedded processors
, Article Microprocessors and Microsystems ; Volume 39, Issue 2 , March , 2015 , Pages 49-63 ; 01419331 (ISSN) ; Ahmadian Khameneh, S ; Goudarzi, M ; Sharif University of Technology
Elsevier
2015
Abstract
Energy reduction in embedded processors is a must since most embedded systems run on batteries and processor energy reduction helps increase usage time before needing a recharge. Register files are among the most power consuming parts of a processor core. Register file power consumption mainly depends on its size (height as well as width), especially in newer technologies where leakage power is increasing. We provide a register file architecture that, depending on the application behavior, dynamically (i) adapts the width of individual registers, and (ii) puts partitions of temporarily unused registers into low-power mode, so as to save both static and dynamic power. We show that our scheme...
Design of a broadband high frequency ultrasound transducer for skin imaging
, Article 6th RSI International Conference on Robotics and Mechatronics, IcRoM 2018, 23 October 2018 through 25 October 2018 ; 2019 , Pages 261-265 ; 9781728101279 (ISBN) ; Chabok, H. R ; Nejat, H ; Sharif University of Technology
Institute of Electrical and Electronics Engineers Inc
2019
Abstract
This paper discusses the design of a high frequency wide bandwidth ultrasound transducer with the center frequency of 50 MHz and an aperture diameter of 3 mm for medical ultrasonic imaging. The piezoelectric material used in this design is Lithium Niobate. The design is verified by both KLM equivalent circuit and spatial impulse response method as used in FIELD II software and the theoretical imaging resolution has been calculated as 50 um axially and 80 um laterally. The possible applications of this probe are skin layer imaging, tumor detection and superficial blood flow measurement
Photocatalytic decolorization of red dye in aqueous ZnO-TiO2 suspensions
, Article International Conference on Smart Materials-Smart! Intelligent Materials and Nano Technology, (SmartMat-'08) and also the 2nd International Workshop on Functional Materials and Nanomaterials (IWOFM-2) ; Volume 55-57 , 2008 , Pages 577-580 ; 10226680 (ISSN); 9780878493562 (ISBN) ; Sadrnezhaad, K ; Kianpoor Rad, M ; Sharif University of Technology
2008
Abstract
The photocatalytic decolorization of aqueous solutions of Direct Red 27 in the presence of various amounts of semiconductor powder suspensions has been investigated in a batch reactor with the use of artificial light sources. ZnO and TiO2 have been found the most active photocatalysts; the effect of catalyst loading and type on the reaction rate was optimized for maximum degradation. The results imply that 1:1 ratio is proper for the photocatalytic removal of Direct Red 27. In addition, the effects of particle size and surface area were examined in this photocatalytic process. The results showed that the decolorization efficiency increases with increase in surface area, and decrease in...
Extremal Black Holes and Decoupled Dynamics of Horizon
,
Ph.D. Dissertation
Sharif University of Technology
;
Arfaei, Hessamaddin
(Supervisor)
Abstract
We study a speci?c class of black holes which are called extremal. By de?ning extremality asdouble-horizon condition and imposing ?niteness assumption, we show that the dynamics of ?eldsat the horizon decouples from the rest of space. This decoupling occurs by vanishing all radialderivatives. We show this decoupling for the extremal black holes in the theories of gravity correctedby f(R)terms.We also show that these two above conditions leads to AdS × S1 near horizon geometry2of rotating black holes. This geometry which preserve SO(2, 1) × U(1) isometry group, is recentlyused in improving the entropy function method. Finally we show that decoupled equations of horizon can be derived from a...
Using machine learning to predict mortality for covid-19 patients on day 0 in the ICU
, Article Frontiers in Digital Health ; Volume 3 , 2022 ; 2673253X (ISSN) ; Asgary, A ; Tavakoli, N ; Zali, A ; Setareh, S ; Esmaily, H ; Jamaldini, S. H ; Daaee, A ; Babajani, A ; Sendani Kashi, M. A ; Jamshidi, M ; Jamal Rahi, S ; Mansouri, N ; Sharif University of Technology
Frontiers Media S.A
2022
Abstract
Rationale: Given the expanding number of COVID-19 cases and the potential for new waves of infection, there is an urgent need for early prediction of the severity of the disease in intensive care unit (ICU) patients to optimize treatment strategies. Objectives: Early prediction of mortality using machine learning based on typical laboratory results and clinical data registered on the day of ICU admission. Methods: We retrospectively studied 797 patients diagnosed with COVID-19 in Iran and the United Kingdom (U.K.). To find parameters with the highest predictive values, Kolmogorov-Smirnov and Pearson chi-squared tests were used. Several machine learning algorithms, including Random Forest...
Feasibility of a powered knee joint in providing stance and swing phase knee flexion when using a knee-ankle-foot orthosis
, Article Journal of Prosthetics and Orthotics ; Volume 29, Issue 4 , 2017 , Pages 177-182 ; 10408800 (ISSN) ; Arazpour, M ; Bahramizadeh, M ; Farahmand, F ; Jamshidi, N ; Samadian, M ; Sharif University of Technology
2017
Abstract
Background The aim of this study was to develop a new stance control knee-ankle-foot orthosis (SCKAFO) and determine its efficacy on specific spatiotemporal and kinematic parameters. Method Seven healthy volunteer subjects participated in this study. After orthotic gait training, subjects participated in a four-part data collection session that consisted of gait evaluation with normal walking, SCKAFO with locked knee joint, SCKAFO without initial flexion (IF) mode, and SCKAFO with IF mode. Results Walking with any of the control knee-ankle-foot orthoses (KAFOs) produced a significant reduction in walking speed compared with normal walking. There was no significant difference in walking speed...
Optimized integrated design of a high-frequency medical ultrasound transducer with genetic algorithm
, Article SN Applied Sciences ; Volume 3, Issue 6 , 2021 ; 25233971 (ISSN) ; Chabok, H. R ; Nejat Pishkenari, H ; Sharif University of Technology
Springer Nature
2021
Abstract
Designing efficient acoustic stack and elements for high-frequency (HF) medical ultrasound (US) transducers involves various interrelated parameters. So far, optimizing spatial resolution and acoustic field intensity simultaneously has been a daunting task in the area of HF medical US imaging. Here, we introduce optimized design for a 50-MHz US probe for skin tissue imaging. We have developed an efficient design and simulation approach using Krimholtz, Leedom and Matthaei (KLM) equivalent circuit model and spatial impulse response method by means of Field II software. These KLM model and Field II software are integrated, and a GA algorithm is used to optimize the design of the US transducer...
A study on microstructures and residual stress distributions in dissimilar friction-stir welding of AA5086-AA6061
, Article Journal of Materials Science ; Volume 47, Issue 14 , 2012 , Pages 5428-5437 ; 00222461 (ISSN) ; Serajzadeh, S ; Sakharova, N. A ; Kokabi, A. H ; Loureiro, A ; Sharif University of Technology
2012
Abstract
Dissimilar friction stir welds of aluminum alloys AA5086 in annealed and AA6061 in T6 temper conditions were investigated in terms of residual stress, grain structure and precipitation distribution in different zones of the welded joints. Optical metallography and transmission electron microscopy were used to characterize microstructures of different zones of the welds. In addition, residual stress profile and local mechanical properties of different zones were evaluated employing X-ray diffraction method and digital image correlation technique. It was found that softening in the AA6061-T6 side occurs in regions with weld peak temperature higher than 300 °C. The micro-hardness profile...
Evolution of a communication protocol between a group of intelligent agents
, Article 2006 World Automation Congress, WAC'06, Budapest, 24 June 2006 through 26 June 2006 ; 2006 ; 1889335339 (ISBN); 9781889335339 (ISBN) ; Shouraki, S. B ; Halavati, R ; Khameneh, E ; Sharif University of Technology
IEEE Computer Society
2006
Abstract
One of the most important issues that be discussed in multi-agent systems, is the communication between agents. In existing applications usually a communication protocol defined between agents. But defining a protocol between agents cause some problems; for example it is possible that agents recognize a subject, but because it is not defined in their protocol, they can't express any thing about that. In this paper we propose a new method for evolution of a communication protocol between intelligent agents, after that the experimental results will be discussed and at the end of the paper future works and conclusion. Copyright - World Automation Congress (WAC) 2006
Performance analysis of spectral-phase-encoded optical CDMA system using two-photon-absorption receiver structure for asynchronous and slot-level synchronous transmitters
, Article Journal of Lightwave Technology ; 2007, Volume 25, Issue 6, Pages 1638-1645 ; Salehi, J. A ; Sharif University Of Technology
Abstract
In this paper, we analyze the performance of a nonlinear two-photon-absorption (TPA) receiver and compare its performance with that of a single-photon-absorption (SPA) receiver in the context of spectral-phase-encoded optical code-division multiple access (CDMA) technique. The performances for the above systems are evaluated for two different transmission scenarios, namely, asynchronous and slot-level synchronous transmitters. Performance evaluation includes different sources of degradation such as multiple-access interference, noise due to optical amplification, shot noise, and thermal noise. In obtaining the performance, the mean and variance of the received signal in each of the above...
Statistical characterization and the bit- error- rate analysis of lightwave systems with optical amplification using two-photon absorption receiver structures
, Article IEEE/OSA Journal of Lightwave Technology ; 2006 Vol. 24, Issue 3, PP. 1302-1316 ; Salehi, J. A ; Sharif University Of Technology
Abstract
In this paper, the authors study the performance of a two-photon absorption (TPA) receiver in a typical communication system employing an optical amplifier. For the study, the authors develop a comprehensive performance analysis, taking into account noises due to an optical amplifier, shot noise, and thermal noise, using Gaussian approximation technique. In evaluating the performance of the system using this technique, the mean and the variance of the received signal will be derived. Comparing the results of receivers using the TPA process with that of a typical single-photon absorption (SPA) structure leads the authors to conclude that TPA receivers can be used when the speed of the...