Complexity of Density Dependencies of Thermal- and Internal- Pressure Compared to that of Total Pressure

, M.Sc. Thesis Sharif University of Technology Sajjadi, Hashem (Author) ; Parsafar, Gholamabbas (Supervisor) ; Goharshadi, Elaheh (Supervisor)

Abstract

A simple equation of state (EoS) has recently been introduced (J. Phys. Chem. B 2009, 113, 11977–11987) as (Z-1) v^2=e+f⁄ρ+gρ^2, where Z≡pv⁄RT is the compressibility factor, v=1⁄ρ is molar volume, and e, f, and g are temperature dependent parameters. This EoS has been found to be accurate for all types of nano- and bulk- solids and bulk fluids, in the entire temperature and pressure ranges for which experimental data are reported, except for the isotherms within the critical region.
The aim of this work is to investigate the validity of a 3-term expression similar to the mentioned EoS for both thermal and internal contributions to the compressibility factor, separately. Such...

Theoretical study of diffusional release of a dispersed solute from a hollow cylindrical polymeric matrix

, Article Scientia Iranica ; Volume 28, Issue 3 , 2021 , Pages 1428-1435 ; 10263098 (ISSN) Jooybar, E ; Tajsoleiman, T ; Abdekhodaie, M. J ; Sharif University of Technology

Sharif University of Technology 2021

Abstract

The present study proposes an exact solution for the release kinetic of a solute from inside a hollow cylindrical polymeric matrix into an infinite medium when the initial concentration of the solute (A) is greater than the solubility limit (Cs). A combination of analytical and numerical methods was used to calculate the solute concentration profile and the release rate. The model was developed for two different conditions including: (1) The release medium was flowing through the hollow cylinder in which the boundary layer may be neglected, and (2) The release medium inside the hollow cylinder was stagnant where the boundary layer needed to be considered. The results indicated that the...

Computational modeling of drug distribution in the posterior segment of the eye: Effects of device variables and positions

, Article Mathematical Biosciences ; Vol. 255, issue. 1 , 2014 , p. 11-20 Jooybar, E ; Abdekhodaie, M. J ; Farhadi F ; Cheng Y. L ; Sharif University of Technology

2014

Abstract

A computational model was developed to simulate drug distribution in the posterior segment of the eye after intravitreal injection and ocular implantation. The effects of important factors in intravitreal injection such as injection time, needle gauge and needle angle on the ocular drug distribution were studied. Also, the influences of the position and the type of implant on the concentration profile in the posterior segment were investigated. Computational Fluid Dynamics (CFD) calculations were conducted to describe the 3D convective-diffusive transport. The geometrical model was constructed based on the human eye dimensions. To simulate intravitreal injection, unlike previous studies...

Developing Polymeric Carriers for Delivery of Platelet Lysate Aiming Tissue Regeneration

, Ph.D. Dissertation Sharif University of Technology Jooybar, Elaheh (Author) ; Abdekhodaie, Mohammad Jafar (Supervisor) ; Mousavi, Abbas (Supervisor)

Abstract

The goal of tissue engineering is the restoration of a tissue function based on combination of cells, scaffolds, and biological signals in an engineered structure. The best way to develop this issue is mimicking the body and host tissues. In the present thesis, it was tried to improve cartilage tissue regeneration from two aspects. In the first part, an injectable hydrogel based on hyaluronic acid (HA) biomaterial was developed which was incorporated with platelet lysate (PL), as an autologous source of growth factors. The human mesenchymal stem cells (hMSCs) were encapsulated in the hydrogel and the effects of PL on the cell attachment, viability and differentiation toward chondrocytes were...

Simulation and Optimization of Drug Delivery Methods to Eye

, M.Sc. Thesis Sharif University of Technology Jooybar, Elaheh (Author) ; Abdekhodaie, Mohammad Jafar (Supervisor) ; Farhadi, Fatollah (Supervisor)

Abstract

In this study a mathematical model for intravitreal injection and depositing controlled release systems in the eye to treat posterior segment deseases is developed. The effects of important parameters that play a critical role in drug distribution are also studied.
Geometrical model is constructed using COMSOL software and governing equations for a 3-D model of drug distribution are solved by finite element method. The geometry is based on the exact dimensions of human eye and retina, choroid and sclera are considered separately. Choroidal losses to the circulatory system and active transport by the retinal pigment epithelium are incorporated as well. Moreover, two types of implant...

Enzymatically crosslinked hyaluronic acid microgels as a vehicle for sustained delivery of cationic proteins

, Article European Polymer Journal ; Volume 115 , 2019 , Pages 234-243 ; 00143057 (ISSN) Jooybar, E ; Abdekhodaie, M. J ; Mousavi, A ; Zoetebier, B ; Dijkstra, P. J ; Sharif University of Technology

Elsevier Ltd 2019

Abstract

In this study, a novel biodegradable hyaluronic acid (HA) based microgel were prepared via enzymatic crosslinking of tyramine conjugated HA (HA-TA) in an inverse microemulsion. HA-TA microdroplets were crosslinked within a few seconds in the presence of horseradish peroxidase (HRP) and hydrogen peroxide (H 2 O 2 ). The high water content of the polymeric network and the inherent negative charge of the HA-TA microgels provided a suitable platform for encapsulation of cationic proteins like lysozyme and TGF-β1 growth factor. The results demonstrated that lysozyme was released, after an initial burst release, in a suitable sustained manner over a period of four weeks. Both diffusion and...

An injectable platelet lysate-hyaluronic acid hydrogel supports cellular activities and induces chondrogenesis of encapsulated mesenchymal stem cells

, Article Acta Biomaterialia ; 2018 ; 17427061 (ISSN) Jooybar, E ; Abdekhodaie, M. J ; Alvi, M ; Mousavi, A ; Karperien, M ; Dijkstra, P. J ; Sharif University of Technology

Acta Materialia Inc 2018

Abstract

Developing scaffolds that can provide cells and biological cues simultaneously in the defect site is of interest in tissue engineering field. In this study, platelet lysate (PL) as an autologous and inexpensive source of growth factors was incorporated into a cell-laden injectable hyaluronic acid-tyramine (HA-TA) hydrogel. Subsequently, the effect of platelet lysate on cell attachment, viability and differentiation of human mesenchymal stem cell (hMSCs) toward chondrocytes was investigated. HA-TA conjugates having a degree of substitution of 20 TA moieties per 100 disaccharide units were prepared and crosslinked in the presence of horseradish peroxidase and low concentrations of hydrogen...

Developing hyaluronic acid microgels for sustained delivery of platelet lysate for tissue engineering applications

, Article International Journal of Biological Macromolecules ; Volume 144 , 2020 , Pages 837-846 Jooybar, E ; Abdekhodaie, M. J ; Karperien, M ; Mousavi, A ; Alvi, M ; Dijkstra, P. J ; Sharif University of Technology

Elsevier B.V 2020

Abstract

Platelet lysate (PL), a blood product that contains high concentrations of growth factors (GFs), can be considered as a cost-effective source of multiple GFs. In this study, hyaluronic acid (HA) based microgels were developed for delivery of PL proteins. Spherical microgel were prepared using a water in oil emulsion method. First, hyaluronic acid was grafted with tyramine groups, after which prepared microdroplets were crosslinked via an enzymatic reaction in the presence of hydrogen peroxide and horseradish peroxidase. Because of electrostatic interactions, these microgels are promising carriers for positively charged proteins entrapment like most of the GFs. When microgels are incubated in...

Pulsating Pulmonary Blood Inflow in Total Cavopulmonary Connection (TCPC) after Fontan Surgery

, M.Sc. Thesis Sharif University of Technology Moradi, Hamed (Author) ; Sayadi, Hassan (Supervisor) ; Firoozabadi, Bahar (Supervisor) ; Navabi Shirazi, Mohammad Ali (Co-Supervisor) ; Malakan Rad, Elaheh (Co-Supervisor)

Abstract

Patients with a single ventricle disease who have undergone Fontan surgery have always had long-term complications. These complications include pulmonary artery stiffness and decreased ability to exercise. In fact, due to removal of the right ventricle from the circulatory system, blood pressure and pulsatility inflow to total cavopulmonary connection (TCPC) are reduced following this surgery. Creating waves (radial displacement) on the IVC (Inferior Vena Cava) wall can increase pulmonary flow pulsations. The Objective of this study is to test the effect of induced wave amplitude on the pulmonary flow pulsations at the rest condition. Computational fluid dynamic (CFD) simulations were...