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Optimization of Biomechanical and Drug Delivery Functions in Engineered Biomaterials In Order to Repair Tissues Exposed to Mechanical Tensions
, M.Sc. Thesis Sharif University of Technology ; Shamloo, Amir (Supervisor)
Abstract
Articular cartilage is connective tissue without any blood vessels or nerves that severely limit its ability to regenerate and repair itself. Although treatments for cartilage repair have been developed, none of them have had satisfactory results. Among modern treatment methods, tissue engineering has attracted a lot of attention. As a non-invasive alternative to treatment and drug delivery to cartilage, thermosensitive scaffolds can provide a porous structure for cell growth, migration, and proliferation. In this study, a theromsensitive and injectable hydrogel was designed and optimized using beta glycerophosphate for controlled release of curcumin. Initially, different ratios of chitosan...
Modeling of an ultrasound system in targeted drug delivery to abdominal aortic aneurysm: a patient-specificin silico study based on ligand-receptor binding
, Article IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control ; Volume 69, Issue 3 , 2022 , Pages 967-974 ; 08853010 (ISSN) ; Boroumand, A ; Ebrahimi, S ; Kalantarnia, F ; Maleki, S ; Moradi, H ; Sharif University of Technology
Institute of Electrical and Electronics Engineers Inc
2022
Abstract
Targeted drug delivery methods have shown a significant impact on enhancing drug delivery efficiency and reducing drug side effects. While various stimuli have been used to promote the drug delivery process, applying ultrasound (US) waves to control drug particles through the human body, noninvasively, has drawn the scientist's attention. However, microcarriers delivery reaches the aneurysmal artery by US waves that exert volumetric forces on blood, and drug carriers, which can therefore affect blood flow patterns and movement pathways of drug carriers, have not yet been studied. In this study, we developed a 3-D patient-specific model of abdominal aortic aneurysm (AAA) to evaluate the...