Design and Fabrication of Microfluidic Chip for Selection of Functional Sperm

, M.Sc. Thesis Sharif University of Technology Ahmadkhani, Nima (Author) ; Saadatmand, Maryam (Supervisor) ; Abdekhodaie, Mohammad Jafar (Supervisor) ; Kazemnejad, Somaieh (Co-Supervisor)

Abstract

Infertility is a growing global issue with significant psychological, economic, and social consequences, which among them, male factor infertility problems make up a considerable portion. The conventional methods of sperm separation inclusive of density-gradient centrifugation and swim-up with numerous problems contain DNA fragmentation and low yield, and both of the methods are not effective for samples with low sperm counts. Modern microfluidic systems are trying to improve this problem by increasing the quality of the isolated sperms. However, most of these systems rely solely on sperm motility as a separation mechanism, which is not a sufficient condition for the separated sperm to be...

Abdominal hollowing and lateral abdominal wall muscles' activity in both healthy men & women: An ultrasonic assessment in supine and standing positions

, Article Journal of Bodywork and Movement Therapies ; Volume 15, Issue 1 , Jan , 2011 , Pages 108-113 ; 13608592 (ISSN) Manshadi, F. D ; Parnianpour, M ; Sarrafzadeh, J ; Azghani, M. R ; Kazemnejad, A ; Sharif University of Technology

2011

Abstract

The objective of this study was to investigate the effects of Abdominal Hollowing (AH) maneuver on External Oblique (EO), Internal Oblique (IO) and Transversus Abdominis (TrA) muscles in both healthy men and women during the two postures of supine and upright standing. The study was conducted on 43 asymptomatic volunteers (22 males and 21 females) aged 19-44 (27.8 ± 6.4) years. Rehabilitative Ultrasonic Imaging (RUSI) was simultaneously performed to measure muscle thickness in both rest and during AH maneuvers while activation of the TrA during AH was controlled by Pressure Biofeedback (PBF) device. Mixed-model ANOVA with repeated measures design, and Pearson correlation tests were used to...

Stabilization exercises and their effect on fear-avoidance belief and disability in patients with recurrent nonspecific low back pain

, Article Koomesh ; Volume 17, Issue 1 , 2015 , Pages 142-151 ; 16087046 (ISSN) Hedayati, R ; Kahrizi, S ; Parnianpour, M ; Bahrami, F ; Kazemnejad, A ; Mobini, B ; Sharif University of Technology

Semnan University of Medical Sciences 2015

Abstract

Introduction: Therapeutic exercises are regarded as one of most important therapeutic interventions for patients with chronic low back pain. Stabilization exercises are among the most practical ones for these patients. Effects of these exercises on psychological factors associated with pain and consequential functional disabilities are still remained unknown. The purpose of this study was to assess the effect of stabilization exercises on fear of pain, movement and disability in patients with low back pain. Materials and Methods: Twenty one patients with recurrent non-specific low back pain (14 in experimental, 7 in control group) were participated in this study. The scores for fear of pain,...

Effect of dual-tasking on postural control in subjects with nonspecific low back pain

, Article Spine ; Volume 34, Issue 13 , 2009 , Pages 1415-1421 ; 03622436 (ISSN) Salavati, M ; Mazaheri, M ; Negahban, H ; Ebrahimi, I ; Jafari, A. H ; Kazemnejad, A ; Parnianpour, M ; Sharif University of Technology

2009

Abstract

STUDY DESIGN. Three factors mixed-design with 1 between-subject and 2 within-subject factors. OBJECTIVE. To compare the main effects and interactions of postural and cognitive difficulty on quiet stance between subjects with and without nonspecific low back pain (LBP). SUMMARY OF BACKGROUND DATA. The interference between postural control and cognitive tasks depends on factors such as sensorimotor/cognitive integrity. Changes in peripheral sensory and muscular systems as well as cognitive processes have been observed in LBP patients. It was hypothesized that the effect of cognitive task on postural performance might be different in subjects with nonspecific LBP as compared with healthy...

Evaluation of bioactivity and biocompatibility of silk fibroin/TiO2 nanocomposite

, Article Journal of Medical and Biological Engineering ; Volume 38, Issue 1 , February , 2018 , Pages 99-105 ; 16090985 (ISSN) Johari, N ; Madaah Hosseini, H. R ; Taromi, N ; Arasteh, S ; Kazemnejad, S ; Samadi Kuchaksaraei, A ; Sharif University of Technology

Springer Berlin Heidelberg 2018

Abstract

Biodegradable polymer/bioceramic nanocomposites are osteoconductive and can accelerate healing of bone tissue. In this research, silk fibroin (SF)/titanium dioxide (TiO2) nanocomposites were synthesized using different concentrations of TiO2 nanoparticles (0, 5, 10, 15 and 20 wt%). The SF/TiO2 nanocomposites were studied in terms of bioactivity and biocompatibility. The in vitro assessment of osteoblasts compatibility indicated that SF inclusion rendered nanocomposite biocompatible whereas presence of TiO2 nanoparticles allowed the cells to adhere and grow on nanocomposite surface and enhanced the bioactivity of the composite. © 2017, Taiwanese Society of Biomedical Engineering

Human papilloma virus and breast cancer: The role of inflammation and viral expressed proteins

, Article BMC Cancer ; Volume 19, Issue 1 , 2019 ; 14712407 (ISSN) Khodabandehlou, N ; Mostafaei, S ; Etemadi, A ; Ghasemi, A ; Payandeh, M ; Hadifar, S ; Norooznezhad, A. H ; Kazemnejad, A ; Moghoofei, M ; Sharif University of Technology

BioMed Central Ltd 2019

Abstract

Background: Breast cancer is currently the most common neoplasm diagnosed in women globally. There is a growing body of evidence to suggest that human papillomavirus (HPV) infection may play a key role in invasiveness of breast cancer. The aim of this study was to determine the presence of HPV in patients with breast cancer and its possible association with cancer progression. Methods: Breast specimens were collected from 72 patients with breast cancer and 31 healthy controls. The presence of HPV was investigated by polymerase chain reaction (PCR) and genotyping was performed for positive cases. We also evaluated the viral factors such as E6, E2, and E7 in HPV positive cases. Enzyme-linked...