Sharif Digital Repository

Lab-On-A-Disk, as a subfield of microfluidic systems, recently has drawn attention to being utilized in blood biomarker diagnosis, blood typing, and immunoassays because of being high-Throughput, highly precise, and easy to use. Blood plasma separation is a most vital unit for pre-processing in these systems, since the blood plasma contains a lot of proteins and enzymes that should be separated, and precisely examined. Therefore, in this paper, for the first time, a numerical model was proposed to evaluate the plasma separation in various time scales and geometries, and an appropriate design was proposed. Furthermore, because the blood plasma volume is different between patients, and the... 

Ideal orientations are one of the material characteristics of the applied mode of deformation. The transfer of material texture to orientations near specific ideal orientations can improve the mechanical properties of the material. In this paper, we focus on the determination of ideal orientations of BCC crystals under the equibiaxial tension mode of deformation. To do this, an Euler space scanning method based on a crystal plasticity approach is presented. In this method some initial orientations which are evenly spaced in the Euler space are selected and their evolutions into the ideal orientations are tracked. The loading is applied incrementally until all of the lattice spin components... 

The lateral response of a single degree of freedom (SDOF) structural system containing a rigid circular cylindrical liquid tank, under harmonic and earthquake excitations is considered. The governing differential equations of motion for the combined system is derived considering the first 3 liquid sloshing modes (1,1), (0,1), and (2,1), under horizontal excitation. The system is considered nonlinear due to the convective term of liquid acceleration and the nonlinear surface boundary conditions, both caused by the inertial nonlinearity. The harmonic and seismic response of the system is investigated in the neighborhood of 1:1 and 1:2 internal resonances between the SDOF system and the first... 

A high-order accurate implicit operator scheme is used to solve steady incompressible slip flow and heat transfer in 2D microchannels. The present methodology considers the solution of the Navier-Stokes equations using the artificial compressibility method with employing the Maxwell and Smoluchowski boundary conditions to model the slip flow and temperature jump on the walls in microchannels. Since the slip and temperature jump boundary conditions contain the derivatives of the velocity and temperature profiles, using the compact method the boundary conditions can be easily and accurately implemented. The computations are performed for a 2D microchannel and a 2D backward facing step in the... 

This paper addresses design of an observer-based adaptive fuzzy controller for a class of single-input-single-output (SISO) nonlinear systems with unknown dynamics subject to input nonlinearity and unknown direction. The proposed controller is singularity free. A high-gain observer is designed to estimate the unmeasured states, and the Lipschitz condition for proving boundedness of the estimated states is relaxed. The Nussbaum function is used to handle the unknown virtual control directions and the backstepping technique has been applied for controller design. It is proved that all closed loop signals are semi-globally uniformly ultimately bounded (SGUUB) and the output tracking error... 

This paper addresses the design of an observer based adaptive neural controller for a class of strict-feedback nonlinear uncertain systems subject to input delay, saturation and unknown direction. The input delay has been handled using an integral compensator term in the controller design. A neural network observer has been developed to estimate the unmeasured states. In the observer design, the Lipschitz condition has been relaxed. To solve the problem of unknown control directions, the Nussbaum gain function has been applied in the backstepping controller design. “The explosion of complexity” occurred in the traditional backstepping technique has been avoided utilizing the dynamic surface... 

This paper addresses design of an observer-based adaptive fuzzy controller for a class of single-input–single-output (SISO) nonlinear systems with unknown dynamics subject to input nonlinearity and unknown direction. The proposed controller is singularity free. A high-gain observer is designed to estimate the unmeasured states, and the Lipschitz condition for proving boundedness of the estimated states is relaxed. The Nussbaum function is used to handle the unknown virtual control directions and the backstepping technique has been applied for controller design. It is proved that all closed loop signals are semi-globally uniformly ultimately bounded (SGUUB) and the output tracking error... 

Chondroitinase ABCI (cABCI) is a drug enzyme that can be used to treat spinal cord injuries. Due to low thermal stability of cABCI, this enzyme was immobilized on Fe3O4 nanoparticle to increase its thermal stability. The size and morphology, structure and magnetic property of the Fe3O4 nanoparticles were characterized by the analyses of SEM, XRD and VSM, respectively, and FTIR spectroscopy was employed to confirm the immobilization of cABCI on the surface of Fe3O4 nanoparticles. The results indicated that the optimum conditions for pH, temperature, cABCI-to-Fe3O4 mass ratio and incubation time in immobilization process were 6.5, 15 °C, 0.75 and 4.5 h, respectively, and about 0.037 mg cABCI... 

Chondroitinase ABC I (cABC I) has received notable attention in treatment of spinal cord injuries and its application as therapeutics has been limited due to low thermal stability at physiological temperature. In this study, cABC I enzyme was immobilized on the dextran-coated Fe3O4 nanoparticles through physical adsorption to improve the thermal stability. The nanoparticles were characterized using XRD, SEM, VSM, and FTIR analyses. Response surface methodology and central composite design were employed to assess factors affecting the activity of immobilized cABC I. Experimental results showed that pH 6.3, temperature 24 °C, enzyme/support mass ratio 1.27, and incubation time 5.7 h were the... 

In this study, the permeability for interdendritic liquid flow through equiaxial mushy zone has been modeled and experimentally measured. In the present work, by applying a virtual dendrite in a micro-domain and solving Navier-Stokes equation, flow pattern around the dendrite has been obtained and then by applying Darcy's law to this 3D domain the permeability has been determined. In this micro-model the influence of solid fraction and geometry of dendrites have been assessed. Numerically determined values of permeabilities have been analyzed by the use of SPSS statistical software. Then an experimental method is used to measure the permeability for flow through equiaxial mushy zone of Pb-Sn... 

In this paper, a flux search controller is proposed to increase the efficiency of a direct torque-controlled induction motor in full load range. The value of the flux reference is determined through a minimization algorithm. The amplitude of stator current is used as the objective function since it is shown that samples of the stator current have better statistical properties than input power. In addition, the stator current has more sensitivity to the flux variation than input power. These two properties allow implementing an adaptive algorithm to determine the proper flux step without waste of time. The minimum allowable value of the flux step has been determined based on this process to... 

In high frequency motor-drives such as direct torque controlled (DTC) induction motor drives, the motor harmonic loss, and electromagnetic interference are largely affected by the spectrum of the motor input voltage. Nonlinear elements in the control loop of DTC drive make harmonic analysis of the drive very complex compared to classical pulsewidth modulated controlled drives. In this paper, a probabilistic method to study the harmonic contents of voltage in DTC of induction motors is presented. The DTC voltage chain is simulated with a random process. Then, the autocorrelation function of voltage vectors is calculated and its power spectrum density is obtained. The effect of flux and torque... 

An ecofriendly one-pot multicomponent reaction of 1,3-dicarbonyl compounds, aldehydes, and malononitrile was carried out in a different deep eutectic solvent (DES) based on choline chloride, to synthesize highly functionalized benzopyran and pyran derivatives under catalyst-free conditions. The results showed that urea:choline chloride based DES is the best solvent and is successfully applicable to a wide range of aldehydes, active methylene compounds with high yields (75-95%) and short reaction times (1-4 h)  

The effects of geometrical scaling on a supersonic external compression axisymmetric inlet are investigated. Various lower and higher geometrical scales of supersonic inlet are considered as the case studies. The inlet flow is simulated numerically using RANS solver along with the SST k-w turbulence model. The numerical results are in an acceptable agreement with the NACA experimental data at free stream Mach number of 1.79 and at zero angle of attack. The results show that the static pressure distribution of the inlet flow experiences some differences for various scales especially at the regions of the flow entrance and throat area. The mean flow Mach number and the mass flow rate at the... 

The lateral response of a single degree of freedom structural system containing a rigid circular cylindrical liquid tank under harmonic and earthquake excitations at a 1:2 autoparametric resonance case is considered. The governing nonlinear differential equations of motion for the combined system are solved by means of a multiple scales method considering the first three liquid sloshing modes (1,1), (0,1), and (2,1), under horizontal excitation. The fixed points of the gyroscopic type of governing differential equations are determined and their stability is investigated employing the perturbation method. The obtained results reveal an increase in the stability region for a single-mode... 

Titania was deposited on glass fibers with a partial epoxy layer coating from a solution containing TiO2 nanoparticles at T = 90°C, and the adsorption process was examined by X-ray photoelectron spectroscopy (XPS), scanning electron microscopy (SEM), energy-dispersive spectroscopy (EDS), Fourier transform infrared (FT-IR) spectroscopy, and photocatalytic activity measurements. XPS data demonstrated that about 25% of the surface was covered with TiO2 nanoparticles, with 10% on the epoxy layer and 15% on the glass body. It was found that TiO2 nanoparticles can be readily adsorbed on epoxy groups, whereas they have a low tendency to adsorb on carbon polymer chains. This difference can be... 

This paper investigates the static and dynamic buckling of an anchored cylindrical steel tank subjected to horizontal and vertical ground acceleration. The buckling capacity of the tank is estimated using static pushover (SPO) and incremental dynamic analyses (IDA). Appropriate load patterns due to the horizontal and vertical components of ground excitations are utilized for SPO analyses. The buckling capacity curves and critical buckling loads computed using SPO analyses are compared to those obtained from IDA. A proper vertical to horizontal acceleration ratio (av/ah) for SPO analysis is proposed that leads to good agreement between SPO and IDA results. © 2017