Sharif Digital Repository

Despite significant progress in cancer treatment, drug resistance remains a major challenge. Synergistic drug combinations offer a promising approach to overcome drug resistance and reduce side effects. Still, despite high-throughput testing technologies, existing drug combination databases suffer from biases and a lack of diversity in tested cancer cell lines, which challenges the prediction of drug response on novel cell targets. To address this critical need, we designed a two-level deep learning method that uses large-scale gene expression datasets to estimate the score and synergy of drug compounds on a wide variety of cancer cell lines. Our model includes an auto-encoder that train on... 

The low female labor force participation rate in the Iranian labor market relative to the global average and even to countries that do not differ significantly from the socio-economic characteristics of our country is one of the important questions of the Iranian labor market. In this study, we seek to answer the question of whether the economic participation rate of married women will increase if the gender gaps in wages, job findings and job losses among women and men are eliminated in the Iranian labor market. To answer this question using household expenditure and income data and labor force data, we show that between the two categories of occupations, in terms of the share of women's... 

Real-time simulators are playing a critical role in the design of power electronic systems. Using real-time simulator enables designers to reduce the time and cost of design by employing hardware-in-the-loop technique. In addition, this simulator can potentially reduce the risks which are associated with performing tests on actual systems. In this thesis, a real-time simulator is designed and implemented for power electronic applications. Concerning the fact that power switches are one of the most important elements in this simulator, an ideal switch model with conduction resistor and RC snubber circuit is used. This model is more accurate as compared to other models in the... 

Fatigue crack growth can have harmful effects on the reliability rotary machine. While an early warning to crack, can be used to extend the life of these expensive machines and increase reliability.Structural Vibration Condition Monitoring as a primary fault detection method, achieved to a lot amazing result and for this reason studies vibration behavior of cracked rotational shaft is a big issue for engineers of dynamic machine.In this research, first check the fault detection methods based on structural vibration condition monitoring, mode shape methods were extracted. Then by modeling rotational shaft in computer and creation of crack on it, fault detection quality of these methods have... 

In the present study, the effects of increasing the value of shale gas production, either due to increased production or price increases, have been studied on economic variables such as employment, wage, property value and the number of births. In this regard, the data for each of these variables was used at the county level in the United States of America between 2000 and 2011. In order to estimate the desired effects, counties are divided into two types of boom and non-boom counties. The findings indicate that increasing natural gas production will lead to more employment and wage growth in boom counties than non-boom counties. Also, during the period of increasing production, the value of... 

It is important to provide an appropriate and economically method with technical and engineering considerations to stabilize excavated underground spaces. The necessity of this, especially for the construction of underground metro stations located in the cities which faces many problems, is more evident. In this research, it has been tried to introduce an optimal method according to the type of area for the construction of the underground station. In order to obtain stress and strain condition in structural elements and surface deformations due to different stages of excavating, numerical modeling in FLAC3D has been used. By examining the parameters that affect the sustainability of this... 

In this study, we aim to learn representations from microscopic cell images that effectively capture the features of drugs affecting the cells, allowing us to identify effective drugs for treating a disease. We employ two parallel learning paths using predictive and generative models. Specifically, we have achieved a predictive model on the RxRx19a dataset that, unlike previous models, is interpretable, optimized, and robust to dras- tic changes in drug properties. Additionally, we have developed the first generative model on this dataset, which not only generates high-quality images but also discovers a meaningful latent space. This latent space divides the representation into relevant... 

Co-movement between inflation and nominal interest in response to an interest rate shock, dubbed neo-fisherianism, has been the subject of contentious debate since the advent of non-inflationary ZLB environment. We design an economic model rich with banking features to understand the economic responses to permanent and long-term interest rate shocks. We find that responses to a permanent positive interest rate shock depend on the monetary authorities’ speculation of the new long-term inflation rate, with the most probable outcome being a permanent increase in inflation. Responses to a long-term positive interest rate shock depict an increase and then decrease in inflation. We also discover... 

Influence of excavating the Tehran metro line 7 tunnel on surface settlement, stresses and deformations induced in Towhid tunnel is investigated using numerical modeling. Construction of Metro tunnel as the new one must be carried out without imposing any damage to the Towhid tunnel as the existing tunnel. Towhid tunnel is a set of twin tunnels along the Chamran highway in Tehran. The tunnels were constructed using sequential excavation method and lined with cast in place reinforced concrete; on the other side metro line 7 is being constructed using 2 EPB tunnel boring machines and lined with reinforced concrete segments. This research consists of the study of the effects of pillar width,... 

Foam injection for enhanced oil recovery is concerned by petroleum engineers because it decreases adverse effects of fingering and gravity segregation caused by the injected fluid .Obviously foam stability is an important factor in the efficiency of this process. So investigating it is an imperative. One of the ways that less studied and can improve foam stability is using of nanoparticles. In this project effect of nanoparticles on foam stability and displacement mechanism during foam flooding has been discussed.
Study consisted of two sets of experiments. In the first part, the static foam stability in the presence of silica nanoparticles has been investigated. Also influence of... 

Miscible displacement in fluid flowing through a porous medium plays an important role in many environmental and industrial applications; for instance, miscible displacements in enhanced oil recovery processes and pollutant spreading in groundwater. A large number of numerical approaches have been developed to solve the advection-dispersion equation that describes the behavior of miscible displacement in porous media. Most of these numerical models suffer from numerical dispersion. Random walk seems to be an effective method to overcome this problem especially in heterogeneous media. Here, a random walk model was developed and used for simulating miscible displacement in heterogeneous porous... 

The use of air bearings was began the last decade. Oil-free air bearing technology is implemented in rotating machines such as turbines, Micro gas turbines and turbocharged, this technology has improved the efficiency of rotating systems. In rotating machines, at high speeds, passing through the critical speed happens. As a result, the natural frequency of the system is crossing the critical speed, which causes system instability and lack of system amplitude control. Instability causes damage to the system. The aim of this thesis is to investigate the nonstationary vibrations of a flexible rotor with air bearings in the passing critical speeds. Behavior of air bearings is also considered to... 

Due to the increasing spread of metal industries and the need for raw material as feed for electric furnaces in order to produce cast iron and steel, as well as scrap deficiency and rising prices, the use of sponge iron as a substitute for scrap was considered in this project Therefore, in order to achieve the chemical analysis of the sorel ingot that is special for spherical graphite cast iron production with low manganese and chromium content, the direct reduction process was carried out using tunnel kiln method on low-manganese iron ore concentrate.After the investigation on direct reduction parameters including the saggers and coal grading,the produced sponge iron has melted in... 

The interaction of perpendicularly tunneling beneath existing metro station is investigated. In this paper E4R7 station, in line 7 of Tehran Metro (Tehran Urban and Suburban Railway co., TUSRC); Iran has been studied. This existing station has some special specifications such as a new pre-supporting system that is called Concrete Arch Pre-supporting System (CAPS). Construction of CAPS is mainly based on an Old Iranian small water tunnels excavation method, Quanat, which is faster and more economical than other common methods. CAPS is a rib like structure consisting of concrete piles and arch beams constructed around underground space before its construction. This method has been utilized in... 

Assuring households’ access to essential goods at economy’s hard times has always been of policymakers’ main concerns. Using Household’s Income and Expenditure Survey data during Iran-Iraq war during 80’s, we have calculated welfare and distribution effects of rationing by coupons of three essential goods in these years. We found that rationed quantities were inefficiently excessive and due to their significant low prices, they were overconsumed. Also, without any extra financial burden, government could have improved lowest income quantile’s aggregate utility by 5.2% or 5.6%, if cash subsidy equal to each household’s previous subsidy value or an equal per-capita subsidy were distributed...