Sharif Digital Repository

Breast cancer is the most common cancer among women and has a growing rate. A combination of the proton beam and Accelerated partial breast irradiation (APBI) strategy can be effective in the case of the respiratory-induced target motion for breast cancer treatment. Due to the proximity of breast tissue to the two critical organ at risks (OARs) such as the lungs and heart, breast cancer proton therapy requires special considerations. The use of proton therapy with respiratory considerations (respiratory-gated), although a powerful way to control the mobile targets in breast cancer proton therapy, but needs to be optimized and improved as much as efficiency.The simulation and modeling of the... 

Formation damage is one of the most important challneges in hydrocarbon production; drilling mud invasion is one of its common types. This damage is caused by the penetration of the drilling fluid into the porous media, which its filtrate and solid pareticles block the pores and cause permeability reduction. The main purpose of this thesis is to investigate the pore-scale mechanisms of the formation damage induced by invert-emulsion drilling fluid and to investigate the effect of adding nanoparticles to the drilling fluid on the severity of the damage using microfluidic technique. According to the latest published articles, there has not been any research conducted at the pore-scale with... 

Considering the world's diminishing oil reserves, as well as the growing demand for oil and energy consumption, Enhanced Oil Recovery (EOR) techniques are becoming increasingly important in the attempt to improve oil production. Engineering salinity waterflooding has gained widespread attention and popularity in the last two decades due to its environmental friendliness, lack of expensive additives, low operating costs, and ease of use as an oil extraction process. The goal of this study is to use an innovative method to develop a mechanistic approach model that simulates and forecasts the mechanism and performance of the engineered water flooding process. Wettability alteration, the most... 

During all operations in oil and gas reservoirs, it is possible to cause formation damage. These damages can greatly reduce the rate of production. One of the major damages that can seriously affect the performance of a reservoir is the damage caused by drilling fluid. The main purpose of this thesis is to study the main mechanisms of formation damage caused by water-based drilling fluid using a glass micromodel for the first time. An accurate understanding of the mechanisms of formation damage can provide a good understanding of the selection of the type and concentration of materials used, as well as appropriate methods to control and eliminate damages. for controlling the drilling fluid... 

Various methods have been developed to improve the production capacity of hydrocarbon wells, one of the most successful method is hydraulic fracture. This method, despite improving well production and increasing production levels in a reservoir, causes secondary damages such as water blockage, which is a result of the leakage of fracturing fluid into the fracture matrix and the deformation of the reservoir. This damage can reduce the production rate of a well. Studies prior to this study have mainly examined the damages caused by the leakage of fracturing fluids on a core scale. In most of these studies, damages has been studied only by measuring the pressure and changes in the permeability... 

A system of electrospun scaffold containing drug-loaded chitosan nanoparticles was introduced for using in spinal cord tissue engineering. In spinal cord injury treatment, the formation of glial scar after injury which contains proteoglycans and activate glial cells should be avoided. In this study, the release of Dexamethasone sodium phosphate (DEXP) as a steroid anti-inflammatory agent from electrospun nanofiber composite containing chitosan nanoparticles was investigated. DEXP is believed to act through its glucocorticoid receptors found in most neurons and glial cells. These receptors’ pathways are involved in the inhibition of astrocyte proliferation and microglial activation.... 

Based on numerous laboratory and field evidence, low-salinity waterflooding or engineered salinity waterflooding can lead to enhanced oil production. According to the literature, the mechanisms involved in this process can be divided into two general categories: fluid-fluid interactions and solid-liquid interactions. These mechanisms are caused by intermolecular and electrostatic forces at the rock and fluid interfaces. The most important controlling factor of the electrostatic forces is the concentration of ions at/near fluids-rock interface. Therefore, improving the concentration of ions causes a shift in wettability toward a more water-wetting state, eventually leading to increased oil...