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    Different PES nanofibrous membrane parameters effect on the efficacy of immunoassay performance

    , Article Polymers for Advanced Technologies ; Volume 30, Issue 8 , 2019 , Pages 1968-1977 ; 10427147 (ISSN) Mahmoudifard, M ; Vossoughi, M ; Sharif University of Technology
    John Wiley and Sons Ltd  2019
    Abstract
    The contribution of electrospun nanofibrous membranes (e.NFMs) in the biosensing platforms opens up a new prospect for the invention of faster and more sensitive analytical devices. In this paper, we utilized e.NFM of polyethersulfone (PES) as a solid substrate for the protein immobilization through two different approaches: physical and covalent. Scanning electron microscopy (SEM) and Fourier-transform-infrared (FTIR) tests were performed to study the effect of plasma treatment on protein immobilization efficacy. Moreover, taking advantage of ELISA technique, the influence of different parameters, namely, nanofibers diameter, membrane thickness, plasma treatment time, an incubation time of... 

    Ammonia plasma-treated electrospun polyacrylonitryle nanofibrous membrane: the robust substrate for protein immobilization through glutaraldhyde coupling chemistry for biosensor application

    , Article Scientific Reports ; Volume 7, Issue 1 , 2017 ; 20452322 (ISSN) Mahmoudifard, M ; Soleimani, M ; Vossoughi, M ; Sharif University of Technology
    2017
    Abstract
    The surface of polyacrylonitrile electrospun nanofibrous membrane (PAN NFM) was aminated by the ammonia plasma treatment. The content of amine groups has been estimated for different time of plasma treatment. The newly generated amine groups were successfully activated by glutaraldehyde (Ga) for the covalent attachment of the protein molecules on the NFM surface. Bio-functionalization of ammonia plasma treated PAN NFM was carried out by the primary antibodies (Ab) immobilization as a protein model through Ga coupling chemistry. For comparison, the immobilization of Ab was also performed through physical interactions. Attenuated total reflection-fourier transform infrared spectroscopy... 

    Electrospun nanofibers: A promising horizon toward the detection and treatment of cancer

    , Article Analyst ; Volume 145, Issue 8 , 2020 , Pages 2854-2872 Asghari, S ; Rezaei, Z ; Mahmoudifard, M ; Sharif University of Technology
    Royal Society of Chemistry  2020
    Abstract
    Due to the increase in the number of cancer patients, because of environmental parameters, high stress, low immunity, etc., there is an urgent need to develop cost-effective sensors for early targeted detection of cancerous cells with adequate selectivity and efficiency. Early disease diagnosis is important, as it is necessary to start treatments before disease progression. On the other hand, we need new, more efficient cancer treatment approaches with minimized side effects, more biocompatibility, and easy disposal. Nanobiotechnology is a field that can assist in developing new diagnostic and treatment approaches, specifically in fatal cancers. Herein, a study on the different applications... 

    Different types of electrospun nanofibers and their effect on microfluidic-based immunoassay

    , Article Polymers for Advanced Technologies ; Volume 30, Issue 4 , 2019 , Pages 973-982 ; 10427147 (ISSN) Mahmoudifard, M ; Vossoughi, M ; Soleimani, M ; Sharif University of Technology
    John Wiley and Sons Ltd  2019
    Abstract
    Protein capturing on polymeric substrate of microfluidic devices is a key factor for the fabrication of immunoassay with high sensitivity. In this work, simple and versatile technique of electrospinning was used to produce electrospun nanofibrous membranes (e.NFMs) with high surface area as a substrate for microfluidic-based immunoassay to increase sensitivity. It was found that the simultaneous use of e.NFM and 1-Ethylethyl-3-(3-dimethylaminopropyl)-carbodiimide/N-Hydroxysuccinimide hydroxysuccinimide as coupling agent has synergic effect on antigen immobilization onto the microchannels. It was found that the oxygen plasma technique for the creation of oxygen containing functional group... 

    Enhancement of Energy Consumption of Real-Time Wireless Sensor Networks by Data Aggregation Techniques

    , M.Sc. Thesis Sharif University of Technology Mahmoudifard, Mehdi (Author) ; Jahangir, Amir Hossein (Supervisor)
    Abstract
    Prolonging the lifetime of wireless sensor networks (WSN) is one of the most important goals in the sensor network research. A lot of work has been done to achieve this goal. Since sensor nodes normally have limited resources in terms of energy, bandwidth and computation capability, efficiency is a key design goal in sensor network research. Data aggregation is a very important method to conserve energy by eliminating the inherent redundancy of raw data in dense WSNs. Previous research on data aggregation has demonstrated its effectiveness in reducing traffic, easing congestion and decreasing the energy consumption. However, few are actually designed for a real world application and... 

    Electrospun polyethersolfone nanofibrous membrane as novel platform for protein immobilization in microfluidic systems

    , Article Journal of Biomedical Materials Research - Part B Applied Biomaterials ; Volume 106, Issue 3 , April , 2018 , Pages 1108-1120 ; 15524973 (ISSN) Mahmoudifard, M ; Vossoughi, M ; Soudi, S ; Soleimani, M ; Sharif University of Technology
    John Wiley and Sons Inc  2018
    Abstract
    In the present study, the feasibility of electrospun polyethersolfone (PES) nanofibrous membrane as the solid substrate for microfluidic based immunoassays to enhance the density of immobilized antibody on the surface of membrane was assessed. Conversely, the efficacy of antibody immobilization was compared by two different strategies as 1-Ethyl-3-(3-dimethylaminopropyl)-carbodiimide (EDC)/N-Hydroxysuccinimide (NHS) coupling chemistry and hydrophobic interaction. Compared to conventional immunoassays carried out in plates or gels, microfluidic based immunoassays grant a lot of advantages such as a consumption of little samples and reagents, shorter analysis time, and higher efficiency.... 

    Electrospun polyethersolfone nanofibrous membrane as novel platform for protein immobilization in microfluidic systems

    , Article Journal of Biomedical Materials Research - Part B Applied Biomaterials ; 2017 ; 15524973 (ISSN) Mahmoudifard, M ; Vossoughi, M ; Soudi, S ; Soleimani, M ; Sharif University of Technology
    John Wiley and Sons Inc  2017
    Abstract
    In the present study, the feasibility of electrospun polyethersolfone (PES) nanofibrous membrane as the solid substrate for microfluidic based immunoassays to enhance the density of immobilized antibody on the surface of membrane was assessed. Conversely, the efficacy of antibody immobilization was compared by two different strategies as 1-Ethyl-3-(3-dimethylaminopropyl)-carbodiimide (EDC)/N-Hydroxysuccinimide (NHS) coupling chemistry and hydrophobic interaction. Compared to conventional immunoassays carried out in plates or gels, microfluidic based immunoassays grant a lot of advantages such as a consumption of little samples and reagents, shorter analysis time, and higher efficiency.... 

    Design and Hardware Implementation of Optical Character Recognition

    , M.Sc. Thesis Sharif University of Technology Dezfuli, Sina (Author) ; Hashemi, Matin (Supervisor)
    Abstract
    The objective of OCR systems is to retrieve machine-encoded text from a raster image. Despite the abundance of powerful OCR algorithms for English, there are not many for Farsi. Our proposed algorithm is comprised of pre-processing, line detection, sub-word detection and segmentation, feature extraction and classification. Furthermore, hardware implementation and acceleration of this system on a GPGPU is presented. This algorithm was tested on 5 fonts including Titr, Lotus,Yekan, Koodak and Nazanin and an average accuracy above 90% was achieved  

    Efficient Implementation of Compressed Deep Convolutional Neural Networks

    , M.Sc. Thesis Sharif University of Technology Afshar, Mohammad (Author) ; Hashemi, Matin (Supervisor)
    Abstract
    Many mobile applications running on smartphones, wearable devices, tiny autonomous robots and IoT devices would potentially benefit from the accuracy and scalability of deep CNN-based machine learning algorithms. However,performance and energy consumption limitations make the execution of such computationally intensive algorithms on embedded mobile devices prohibitive.We present a GPU-accelerated engine, dubbed mCNN, for execution of trained deep CNNs on mobile platforms. The proposed solution takes the trained model as input and automatically optimizes its parallel implementation on the target mobile platform for efficient use of hardware resources such as mobile GPU threads and SIMD units.... 

    Design and Efficient Hardware Implementation of Spiking Neural Networks on FPGA

    , M.Sc. Thesis Sharif University of Technology Amirshahi, Alireza (Author) ; Hashemi, Matin (Supervisor)
    Abstract
    Spiking Neural Networks(SNN) are networks which are consisted of layers of neurons, like other typical artificial neural networks. The main difference between SNN and other neural networks is the type of data transportation among neurons which is done by spikes. Spiking neural networks and their models are considered as the nearest networks and neurons to animals’ nervous systems. In aspects of hardware implementation, the type of data transportation in SNN causes them to be ultra-low power. So, implementation of these networks on chips like FPGA and also usage of SNN in applications with high processing load have startling germination, recently. In this work, we have tried to propose some... 

    Parallel Implementation of Telecommunication Decodings in Real-time

    , M.Sc. Thesis Sharif University of Technology Jafarzadeh, Ali (Author) ; Hashemi, Matin (Supervisor)
    Abstract
    Many chip manufacturers have recently introduced high-performance deep-learning hardware accelerators. In modern GPUs, programmable tensor cores accelerate the heavy operations involved in deep neural networks. This paper presents a novel solution to re-purpose tensor cores in modern GPUs for high-throughput implementation of turbo decoders. Turbo codes closely approach Shannon’s limit on channel capacity, and are widely used in many state-of-the-art wireless systems including satellite communications and mobile communications. Experimental evaluations show that the proposed solution achieves about 1.2 Gbps throughput, which is higher compared to previous GPU-accelerated solutions  

    Disentangled Representation Learning for Automated Clothe Image Synthesis on the Body

    , M.Sc. Thesis Sharif University of Technology Johary, Iman (Author) ; Hashemi, Matin (Supervisor)
    Abstract
    There have been many works on generative networks and image generation in the past few years, but the problem with this work is that there is no control over the generated images. The goal of disentangled image synthesis is to generate new images with specific detail and have control over the generated images. Image-based virtual try-on aims to synthesize the customer image with an in-shop clothes image to acquire seamless and natural try-on results, which have attracted increasing attention. The main procedures of image-based virtual try-on usually consist of clothes image generation and try-on image synthesis. In contrast, prior arts cannot guarantee satisfying clothes results when facing... 

    Viterbi Decoder Implementation on GPGPU

    , M.Sc. Thesis Sharif University of Technology Mohammadidoost, Alireza (Author) ; Hashemi, Matin (Supervisor)
    Abstract
    In this project, a method is emoloyed to implement a Viterbi decoder on GPGPU. This method is based on combining all steps of the algorithm. This combination has some challenges that are related to differences between different steps of the algorithm. So in this project, some solutions are found to handle these challenges and a high-throughput Viterbi decoder is acheived  

    Dual improvement of DNA-directed antibody immobilization utilizing magnetic fishing and a polyamine coated surface

    , Article RSC Advances ; Volume 6, Issue 112 , 2016 , Pages 111210-111216 ; 20462069 (ISSN) Esmaeili, E ; Soleimani, M ; Shamloo, A ; Mahmoudifard, M ; Vossoughi, M ; Sharif University of Technology
    Royal Society of Chemistry  2016
    Abstract
    The present study is aimed at the development of a novel approach based on the magnetic improvement of DNA-directed antibody immobilization to prepare a highly efficient sensing platform. Magnetic nanoparticle substrates with high surface area capture the dual DNA-conjugated antibodies in a solution. This allows overcoming the typical mass transport limitation of the surface-based antibody immobilization. Antibody-magnetic nanoparticle conjugation is based on a robust hybridization between a DNA tether (attached to the antibody) and its complementary sequence (immobilized on the nanoparticle). Conventional antibody immobilization for the detection of proteins is often insignificant for the... 

    Design and Efficient Implementation of Deep Learning Algorithm for ECG Classification

    , M.Sc. Thesis Sharif University of Technology Oveisi, Mohammad Hossein (Author) ; Hashemi, Matin (Supervisor)
    Abstract
    Cardiovascular diseases are the leading cause of death globally so early diagnosis of them is important. Many researchers focused on this field. First signs of cardiac diseases appear in the electrocardiogram signal. This signal represents the electrical activity of the heart so it’s primarily used for the detection and classification of cardiac arrhythmias. Permanent monitoring of this signal is not possible for specialists so we should do this by means of Artificial Intelligence. In this thesis, we use recurrent neural networks to classify electrocardiogram’s arrhythmias. This deep learning method, use two sources of data to learn from. The first part of data is global for everyone and the... 

    Numerical Modeling of Fuel Droplet Vaporization in Gas Phase at Supercritical Conditions

    , M.Sc. Thesis Sharif University of Technology Rajabi Matin, Zahra (Author) ; Hejranfar, Kazem (Supervisor)
    Abstract
    The study of evaporation of fuel droplet and determination of the rate of vaporization are important in designing combustion chambers. For achieving high performance of a combustor, the evaporation of fuel droplets takes place within a high pressure environment. At these conditions, the use of low-pressure models is not appropriate and many effects that are assumed negligible at low ambient pressures become very important. For example, the solubility of the ambient gas into the liquid phase is increased by increasing the ambient pressure. In addition, the ideal gas assumption is not valid for these conditions and one should use an appropriate equation of state (EOS) that can predict the... 

    Applying flow zone index approach and artificial neural networks modeling technique for characterizing a heterogeneous carbonate reservoir using dynamic data: Case Study of an Iranian reservoir

    , Article Society of Petroleum Engineers - Trinidad and Tobago Energy Resources Conference 2010, SPE TT 2010, 27 June 2010 through 30 June 2010 ; Volume 2 , June , 2010 , Pages 677-690 ; 9781617388859 (ISBN) Shahvar, M. B ; Kharrat, R ; Matin, M ; Sharif University of Technology
    2010
    Abstract
    Although static characterization of reservoirs is an inevitable part of any reservoir studies, the most robust models of the reservoirs can be obtained through integrating static and dynamic data. The following study which is done in a heterogeneous carbonate reservoir utilizes the capillary pressure and relative permeability data to verify the task of static rock typing and investigate the role of hydraulic units in capillary pressure and relative permeability modeling. For this purpose, at first, various rock typing techniques are applied to the field data to seek the best method which has the most consistency with capillary pressure curves. Using Desouky method which is based on hydraulic... 

    Applying the Taguchi method to develop an optimized synthesis procedure for nanocrystals of T-type zeolite

    , Article Chemical Engineering and Technology ; Volume 32, Issue 7 , 2009 , Pages 1042-1048 ; 09307516 (ISSN) Tehrani Matin, K ; Bastani, D ; Kazemian, H ; Sharif University of Technology
    2009
    Abstract
    The effects of H2O/SiO2, TMAOH/SiO2, Na/(Na+K), and SiO2/Al2O3 ratios in the parent gels on the crystallization of nanoparticles of T-type zeolites were studied. A Taguchi orthogonal experimental design with the above-mentioned parameters (each at three levels) was used to optimize the experiment parameters by the analysis of variances (ANOVA). Applying the Taguchi method significantly reduced the time and cost required for optimization. The synthesized products were characterized by X-ray diffraction and scanning electron microscopy. As a result of the Taguchi analysis, H2O/SiO2 and TMAOH/SiO2 were the most influencing parameters for the synthesis of zeolite T. © 2009 WILEY-VCH Verlag GmbH... 

    Design and Efficient Implementation of Neural Networks for Solving Graph-based Problems

    , M.Sc. Thesis Sharif University of Technology Mahdipour Araste, Payam (Author) ; Hashemi, Matin (Supervisor)
    Abstract
    The extraordinary ability of the human brain to solve various problems has led scientists to simulate models of the human brain. One of these simulated models is artificial neural networks. Today, the power of artificial neural networks is not overlooked. The ability of artificial neural networks to solve various types of issues led us to use the thesis to solve some of the graph-based problems. Quite accurately, this graph-based problem is a matter of identifying the source of rumor in a network. In many graph networks, whether natural networks such as the network of neurons in the human brain or synthetic ones such as the types of social networks, it is possible that a rumor spreads across... 

    Efficient protein immobilization on polyethersolfone electrospun nanofibrous membrane via covalent binding for biosensing applications

    , Article Materials Science and Engineering C ; Volume 58 , 2016 , Pages 586-594 ; 09284931 (ISSN) Mahmoudifard, M ; Soudi, S ; Soleimani, M ; Hosseinzadeh, S ; Esmaeili, E ; Vossoughi, M ; Sharif University of Technology
    Elsevier Ltd  2016
    Abstract
    In this paper we introduce novel strategy for antibody immobilization using high surface area electrospun nanofibrous membrane based on ethyl-3-(3-dimethylaminopropyl)-carbodiimide/N-hydroxysuccinimide (EDC/NHS) coupling chemistry. To present the high performance of proposed biosensors, anti-staphylococcus enterotoxin B (anti-SEB) was used as a model to demonstrate the utility of our proposed system. Polymer solution of polyethersolfone was used to fabricate fine nanofibrous membrane. Moreover, industrial polyvinylidene fluoride membrane and conventional microtiter plate were also used to compare the efficiency of antibody immobilization. Scanning electron microscopy images were taken to...