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, M.Sc. Thesis Sharif University of Technology ; Mahmoodian, Ebadollah (Supervisor)Modeling of Cancer Progression by Using Evolutionary Game Theory
, M.Sc. Thesis Sharif University of Technology ; Habibi, Jafar (Supervisor)
Abstract
Mathematical modeling and computer simulation are powerful tools to help cancer research because they provide a good insight of cancer progression and an efficient framework to test biological hypothesis. Most of the previous studies ignored many intracellular communication between tumor cells. Gap junction is one of the interaction ways between tumor cells which plays a crucial role in cancer progression. In the first phase of this thesis, a model of intracellular communication through gap junction using evolutionary game theory scoring is proposed. In the second phase of this thesis, cancer is modeled by Markov decision process (MDP). Given that considering nutrient level constant is one...
Monitoring of Ion Implanter Radiation
, M.Sc. Thesis Sharif University of Technology ; Rashidian, Bizhan (Supervisor)
Abstract
X-ray radiation is an ionizing radiation that can be produced under some conditions in an ion implanter and can have significant effects on equipment and personnel health. In this dissertation, we first examine the properties of ionizing radiations and their effects of electronic devices and discuss the general properties of common detectors. Next, Using Silvaco TCAD and GEANT4 we will simulate the interaction of ionzing radiation with energies up to 300 keV with electronic devices including a commercial off the shelf photo diode and a specialized x-ray detector and show that these devices can efficiently reveal informations of a radiation source to the user. Also, it has been shown that...
On The Existence of Arithmetic Progressions In Subsets of Integers
, M.Sc. Thesis Sharif University of Technology ; Alishahi, Kasra (Supervisor) ; Hatami, Omid (Supervisor)
Abstract
Suppose that A is a large subset of N. It is interesting to think about the arithmetic progressions in A.In 1936, Erdos and Turan conjectured that for > 0 and k 2 N, there exists N = N(k; ) that for all subsets A {1; 2; : : : ;N}, if lAl N, A has a nontrivial arithmetic progression of length k. Roth proved the conjecture for k = 3 in 1953. In 1969, Szemeredi proved the case k = 4 and in 1975, he gave a combinatorial proof for the general case. In 1977, using ergodic theory, Furstenberg gave a different proof for the Erdos-Turan conjecture (or Szemeredi Theorem!) and finally Gowers found another proof for the Szemeredi theorem, which was an elegant generalization of the Roth’s proof for k =...
Investigation of the Effect of Lithium Addition on the Microstructure, Mechanical Properties, and Biodegradability of Zn-Mg Alloys
, M.Sc. Thesis Sharif University of Technology ; Alizadeh, Reza (Supervisor) ; Ashouri, Hossein (Supervisor)
Abstract
Nowadays, zinc has attracted significant attention as a biodegradable material due to its suitable degradation rate and the absence of harmful gas evolution during degradation. However, the relatively poor mechanical properties of zinc necessitate improvement through alloying. In this regard, the present study investigates the effect of lithium addition on Zn-Mg alloys. The addition of lithium to Zn-Mg alloys remarkably enhances their mechanical and corrosion properties. The main objective of this study is to improve the mechanical properties while maintaining the corrosion resistance of Zn-0.5Mg and Zn-1Mg alloys by adding various amounts of lithium, aiming to meet the functional...
Integrating evolutionary game theory into an agent-based model of ductal carcinoma in situ: Role of gap junctions in cancer progression
, Article Computer Methods and Programs in Biomedicine ; Volume 136 , 2016 , Pages 107-117 ; 01692607 (ISSN) ; Habibi, J ; Zangooei, M. H ; Aghakhani, H ; Sharif University of Technology
Elsevier Ireland Ltd
2016
Abstract
Background and objective There are many cells with various phenotypic behaviors in cancer interacting with each other. For example, an apoptotic cell may induce apoptosis in adjacent cells. A living cell can also protect cells from undergoing apoptosis and necrosis. These survival and death signals are propagated through interaction pathways between adjacent cells called gap junctions. The function of these signals depends on the cellular context of the cell receiving them. For instance, a receiver cell experiencing a low level of oxygen may interpret a received survival signal as an apoptosis signal. In this study, we examine the effect of these signals on tumor growth. Methods We make an...
Experimental and Numerical Study of a Shape Memory Alloy Wire Rope Behavior in Release Mechanism
, M.Sc. Thesis Sharif University of Technology ; Naghdabadi, Reza (Supervisor) ; Arghavani Hadi, Jamal (Supervisor)
Abstract
Smart materials are able to change their physical properties under various environmental conditions. Shape memory alloys (SMA) are relatively new smart materials that can respond to environmental stimuli e.g., heat, electricity, etc. Unique behaviors of SMAs, called shape memory effect and superelasticity, have motivated many applications in various fields of study (aerospace, medical, civil engineering, etc.). Although the behavior of SMAs is complicated, modeling and utilizing these materials have been receiving much attention in the past 20 years. Since a cable tolerate more tension than a wire or rod, the shape memory alloy cables could have a broad range of potential applications....
Mesoporous silica nanoparticles (MCM-41) coated PEGylated chitosan as a pH-Responsive nanocarrier for triggered release of erythromycin [electronic resource]
, Article International Journal of Polymeric Materials and Polymeric Biomaterials ; 2014, Volume 63, Issue 13, Pages 692-697 ; Mazaheri Tehrani, Zahra ; Sharif University of Technology
Abstract
A pH-responsive drug delivery system based on core shell structure of mesoporous silica nanoparticle (MSN) and chitosan-PEG copolymer was prepared and characterized by Fourier transform infrared spectroscopy (FT-IR), thermogravimetric analysis (TGA), scanning electron microscope (SEM), and high-resolution transmission microscope (HR-TEM) techniques. In order to improve compatibility MSN and drug, mesoporous nanosilica was modified by 3-aminopropyl triethoxysilane. The release of erythromycin (a macrolide antibiotic) as a model drug was investigated in two pHs, 7.4 and 5.5
Optimising multi-item economic production quantity model with trapezoidal fuzzy demand and backordering: Two tuned meta-heuristics
, Article European Journal of Industrial Engineering ; Volume 10, Issue 2 , 2016 , Pages 170-195 ; 17515254 (ISSN) ; Niaki, S. T. A ; Malekian, M. R ; Sadeghi, S ; Sharif University of Technology
Inderscience Enterprises Ltd
2016
Abstract
In this paper, a multi-item economic production quantity model with fuzzy demand is developed in which shortages are backordered and the warehouse space is limited. While the demand is assumed to be a trapezoidal fuzzy number, the centroid defuzzification method is used to defuzzify fuzzy output functions. The Lagrangian relaxation procedure is first employed to solve the problem. Then, the model is extended to a constrained fuzzy integer nonlinear programming, in order to suit real-world situations. As the extended model cannot be solved in a reasonable time using exact methods, two meta-heuristic algorithms, named the genetic algorithm (GA) and the particle swarm optimisation (PSO) each...
A Lagrangian relaxation for a fuzzy random EPQ Problem with Shortages and Redundancy Allocation: Two Tuned Meta-heuristics
, Article International Journal of Fuzzy Systems ; Volume 20, Issue 2 , 2018 , Pages 515-533 ; 15622479 (ISSN) ; Niaki, S. T. A ; Malekian, M. R ; Wang, Y ; Sharif University of Technology
Springer Berlin Heidelberg
2018
Abstract
This paper develops an economic production quantity model for a multi-product multi-objective inventory control problem with fuzzy-stochastic demand and backorders. In this model, the annual demand is represented by trapezoidal fuzzy random numbers. The centroid defuzzification and the expected value methods are applied to defuzzify and make decisions in a random environment. In the case where the warehouse space is limited, the Lagrangian relaxation procedure is first employed to determine the optimal order and the maximum backorder quantities of the products such that the total inventory cost is minimized. The optimal solution obtained by the proposed approach is compared with that...
Theoretical and Computational Investigation of Quantum Plasmonic Properties of Nanocluster Dimers
, M.Sc. Thesis Sharif University of Technology ; Jamshidi, Zahra (Supervisor)
Abstract
In today's era, metal nanoparticles play an important role in technologies emerging from different sciences, such as chemistry, physics, optics, material science, due to their unique characteristics. In the development of nanooptics science, it can be said that metal nanoparticles play an important role. The ability of conductive electrons collective oscillation causes surface charge density fluctuations in nanoparticles, this phenomenon is known as surface plasmons. Surface plasmons are surprisingly coupled with light and cause the significant increase in the intensity of optical fields induced in nanoparticles. Therefore, with the presence of localized surface plasmons or plasmon...
Theoretical Investigation of Ab-initio MD Approach to Increase the Efficiency and Accuracy of VCD Spectrum Calculation
, M.Sc. Thesis Sharif University of Technology ; Jamshidi, Zahra (Supervisor)
Abstract
Understanding of the Molecules is the main purpose of the chemistry. Ab-initio molecular dynamics (AIMD) as a branch of the computational chemistry, tries to give us a deep comprehension of the molecule, and its chemical, physical and optical activities. This comprehension, relies on the accuracy of quantum mechanics, in addition to the speed of the classical mechanics. The mixing of the quantum mechanics and the classical mechanics could simulate activities of the atoms in the time-domain, provided the mixing is done with precaution. This, in turn, helps us to forecast the response of a molecule in different situations, and also translating the macroscopic phenomena in a nanoscopic...
Investigation of Plasmonic Excitation in Carbonic Nanostructures Within Near-IR
, M.Sc. Thesis Sharif University of Technology ; Jamshidi, Zahra (Supervisor)
Abstract
To date, the plasmonic properties of many metallic and semi-conducting materials have been investigated and used in various industries. One of the plasmonic material categories that have always been considered is polycyclic aromatic hydrocarbon or PAH, whose plasmonic resonance energy depends on the charge state of the molecule. In this regard, it is easy to change the plasmonic resonance energy via changing the induced charge, which is a unique feature of the mentioned materials. In addition, plasmonic structures with excitations in the infrared region are able to enhance the vibration intensity of absorbed molecules by increasing the electric field around themselves. Therefore, they have...
Using Nonlinear Effects of Light for Optical Signal Processing
, M.Sc. Thesis Sharif University of Technology ; Kavehvash, Zahra (Supervisor)
Abstract
Ultrafast signal processing in time-domain with high resolution and reconfigura-bility is a challenging task. This paper, for the first time, introduces a time-varying metasurface consisting of graphene microribbon array for implementing time-lens in the terahertz domain. Given that the surface conductivity of graphene is proportional to the Fermi energy level in the THz regime, it is possible to change the phase property of the incident electromagnetic pulse by changing the Fermi level while the Fermi level itself is a function of voltage. Upon this fact, a quadratic temporal phase modulator, namely time-lens has been realized. This phase modulation is applied to the impinging signal in the...
Using Simulation-Optimization Approach for Fire Station Location and Vehicle Assignment Problem: a Case Study in Tehran, Iran
, M.Sc. Thesis Sharif University of Technology ; Amini, Zahra (Supervisor)
Abstract
In this research, the problem of locating fire stations and allocating equipment has been studied and a simulation-optimization approach has been presented to solve the problem. The mathematical models of this research were developed based on the idea of the randomness of the covered demand and the maximum expected coverage model. In these models, the issue of non-availability of equipment to cover accidents, the random nature of accidents, various fire incidents and the equipment needed to cover them are considered. Two mathematical models with deterministic and non-deterministic approach with different scenarios for demand are proposed. The non-deterministic model is developed with the aim...
Introducing An Integrated Framework For Solving The Fleet Planning Problem Using A Simulation-Optimization Approach
, M.Sc. Thesis Sharif University of Technology ; Amini, Zahra (Supervisor)
Abstract
One of the main concerns of industrial companies’ managers is providing an efficient logistics system. To achieve an efficient logistics system, the fleet planning problem is studied by many researchers in recent years. This problem consists of multiple sub-problems at three levels: operational, tactical, and strategic. These sub-problems are closely related to each other and need to be studied and addressed in an integrated manner. In this research, an attempt is made to provide an integrated framework to solve the vehicle routing problem (operational), outsourcing problem (tactical), and fleet composition problem (strategic). These problems have various uncertainties, including customer...
Analytical Modelling and Optimization of Disk Type, Slot Less Resolver
, M.Sc. Thesis Sharif University of Technology ; Nasiri Gheidari, Zahra (Supervisor)
Abstract
Resolvers, due to their robust structure, are widely used in automation systems. Among the types of resolvers, the accuracy of the Wound Rotor (WR) resolver in the occurrence of common mechanical errors is higher than other types of resolvers. therefore, in this thesis, an AFWRR is studied to improve the performance. Increasing the number of poles in WR resolvers is a good solution for increasing the accuracy of these electromagnetic position sensors. However, high-speed WR resolvers due to employing fractional slot windings suffer from rich sub-harmonics in the induced voltages. A common solution for suppressing the undesirable sub-harmonics is using multi-layer winding with appropriate...
A Survey on Searchable Symmetric Encryption Schemes
, M.Sc. Thesis Sharif University of Technology ; Khazaei, Shahram (Supervisor)
Abstract
Using “Searchable Encryption” enables us to encrypt the data, while preserving the possibility of running search queries. One of the most important applications of the mentioned is in Cloud Storage. As users do not trust the Cloud space, they are not inclined to store their data on the Could. The solution to this problem is of course, Cryptography. However, ordinary Cryptography methods, eliminate the data’s searchability. Hence, we need encryption schemes that code the data while retaining their searchability. So far, various schemes has been proposed that differ in their performance, security level, and usage. In this thesis, we aim to discuss and analyze these methods
Time Domain Optical Signal Processing Based on the Duality Between Dispersion and Diffraction
, M.Sc. Thesis Sharif University of Technology ; Kavehvash, Zahra (Supervisor)
Abstract
In the last decades, due to the growing demand of transferring information with high transmission rates, the complexity and development of telecommunication and optical systems is remarkable. Researchers around the world attempt to explore extraordinary potential of light to process information. In the mid-19th century, scientists discovered a mathematical symmetry between the spatial and temporal optics fields, which originated from the similarity of equations governing the paraxial diffraction of beams and the dispersion of narrow-band pulses known as space– time duality in scientific texts. This new approach provides more advanced and potent methods to temporal processing and...
Improving the Stability of an Urban Traffic Network with Limited Data by Using Percolation Theory and Dynamic Clustering
, M.Sc. Thesis Sharif University of Technology ; Amini, Zahra (Supervisor)
Abstract
One of the most vital aspects of understanding the traffic phenomenon is scrutinizing the traffic transition status, such as the transition from free flow to congestion. The Percolation Theory is a renowned theory focusing on analyzing various network types to detect the critical zones, which are the zones including links that are important to control to improve stability. By calculating the quality indices of network links, the Percolation Theory can simulate the traffic percolation propagation in the network and determine possible critical zones for further analysis. Most studies in this field assume access to data of several traffic parameters for the entire transportation network, such...