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Simulation of Optimum Nutrition in Bioreactors
, M.Sc. Thesis Sharif University of Technology ; Abdekhodaie, Mohammad Jafar (Supervisor) ; Mehrvar, Mehrab (Supervisor)
Abstract
In this study, a semi-structured model for the growth and production of lactase in an aerated bioreactor by Kluyveromyces marxianus, growing on cheese whey, was developed. Three modes of culture, consisting of batch, fed-batch and a controlled-release system were investigated. Modeling was based on three metabolic pathways, representing the growth of Kluyveromyces marxianus. Lactose and oxygen consumption, cell growth, and also lactase and ethanol production rates were determined in the model. Induction was considered as the governing mechanism for enzyme production. The model showed good agreement with the experimental data in batch and fed-batch cultures. Controlled-release system is a...
Effect of Feeding Strategy on Lactase Production
, M.Sc. Thesis Sharif University of Technology ; Yaghmaei, Soheyla (Supervisor) ; Abdekhodaie, Mohammad Jafar (Supervisor) ; Mehrvar, Mehrab (Supervisor)
Abstract
Kluyveromyces genus is known to be one of the important yeast used in processes of industrial biotechnology. This importance is due to production of Lactase, key enzyme in dairy industries that catalyses hydrolysis of lactose in milk. But high concentration of carbon source which is lactose in most cases, causes crab-tree effect, a metabolic pathway that leads to more production of ethanol rather than lactase. In this research the main purpose was to control the initial lactose concentration in medium to prevent decrease in enzyme activity. Controlled release system via Ethylene Vinyl Acetate tablets was chosen as a controller mechanism of lactose concentration as EVA was a well-known...
Quantum Error Correction and Fault-Tolerant Quantum Computation
, M.Sc. Thesis Sharif University of Technology ; Karimipour, Vahid (Supervisor)
Abstract
Quantum states are highly susceptible to noise and can lose their coherence easily. Thus, for the large-scale quantum algorithms results to be valid, it is necessary to use an error correction process to eliminate the errors. The theory of quantum error correction provides a comprehensive methodology for protecting quantum states against noise. In this theory, by adding ancilla qubits and carefully encoding, quantum states are prepared such that they can be robust to a great extent against errors. To perform a scalable quantum computation, we face an even more daunting task. If our quantum gates are imperfect, everything we do will add to the error. So the quantum error correction could be...
Nano mesoporous silica for cancer treatment: ROS-responsive and redox-responsive carriers
, Article Journal of Drug Delivery Science and Technology ; Volume 57 , 2020 ; Abdekhodaie, M. J ; Behroozi, F ; Mehrvar, M ; Sharif University of Technology
Editions de Sante
2020
Abstract
Reactive oxygen species ROS and redox agents are two features of cancer medium, which could be used through responsive drug delivery systems for cancer treatment. Furthermore, mesoporous silica nanoparticles (MSNs) have special characteristics to use them in ROS-responsive and redox-responsive carriers. To shed light on this issue, we propose two drug delivery systems: 1) responsive to hydrogen peroxide (a ROS component) and 2) responsive to dithiothreitol (a redox agent). The proposed carriers are composed of 4 parts: MSNs, responsive agent (selenocystine for ROS-responsive and dithiodipropionic for the redox-responsive carrier), hyaluronic acid as the coating and targeting agent, and the...
Combined UV-C/H2O2-VUV processes for the treatment of an actual slaughterhouse wastewater
, Article Journal of Environmental Science and Health - Part B Pesticides, Food Contaminants, and Agricultural Wastes ; Volume 52, Issue 5 , 2017 , Pages 314-325 ; 03601234 (ISSN) ; Bustillo Lecompte, C. F ; Mehrvar, M ; Abdekhodaie, M. J ; Sharif University of Technology
Taylor and Francis Inc
2017
Abstract
In this study, a three-factor, three-level Box-Behnken design with response surface methodology were used to maximize the TOC removal and minimize the H2O2 residual in the effluent of the combined UV-C/H2O2-VUV system for the treatment of an actual slaughterhouse wastewater (SWW) collected from one of the meat processing plants in Ontario, Canada. The irradiation time and the initial concentrations of total organic carbon (TOCo) and hydrogen peroxide (H2O2o) were the three predictors, as independent variables, studied in the design of experiments. The multiple response approach was used to obtain desirability response surfaces at the optimum factor settings. Subsequently, the optimum...
A hybrid scaffold of gelatin glycosaminoglycan matrix and fibrin as a carrier of human corneal fibroblast cells
, Article Materials Science and Engineering C ; Volume 118 , 2021 ; 09284931 (ISSN) ; Mahdavi salimi, S ; Abdekhodaie, M. J ; Baradaran Rafii, A ; Tabatabei, M. R ; Mehrvar, M ; Sharif University of Technology
Elsevier Ltd
2021
Abstract
A hybrid scaffold of gelatin-glycosaminoglycan matrix and fibrin (FGG) has been synthesized to improve the mechanical properties, degradation time and cell response of fibrin-like scaffolds. The FGG scaffold was fabricated by optimizing some properties of fibrin-only gel and gelatin-glycosaminoglycan (GG) scaffolds. Mechanical analysis of optimized fibrin-only gel showed the Young module and tensile strength of up to 72 and 121 KPa, respectively. Significantly, the nine-fold increase in the Young modulus and a seven-fold increase in tensile strength was observed when fibrin reinforced with GG scaffold. Additionally, the results demonstrated that the degradation time of fibrin was enhanced...