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mirshafeeyan--mahshad
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Hydrogel Design and Development for Osteoarthritis Treatment
, M.Sc. Thesis Sharif University of Technology ; Yaghmaei, Soheyla (Supervisor) ; Mashayekhan, Shohreh (Supervisor)
Abstract
"osteoarthritis" is one of the most common joint diseases. This disease has a close relationship with factors such as aging, weight gain, genetics, mechanical pressures, and severe injuries. Although the mechanism of this disease is not fully understood, inflammation is one of the main causes of its exacerbation and progression. controlling inflammation can greatly help in controlling the disease. One of the common treatment methods for osteoarthritis is intra-articular injection of hyaluronic acid and triamcinolone as anti-inflammatory drug. Hyaluronic acid is the main component of synovial fluid, with its viscosupplementation property, prevents bones from rubbing against each other in the...
In silico design and mechanistic study of niosome-encapsulated curcumin against multidrug-resistant staphylococcus aureus biofilms
, Article Frontiers in Microbiology ; Volume 14 , 2023 ; 1664302X (ISSN) ; Sahrayi, H ; Hafezi, Y ; Mirshafeeyan, M ; Salehi Moghaddam, Z ; Farasati Far, B ; Noorbazargan, H ; Mirzaie, A ; Ren, Q ; Sharif University of Technology
Frontiers Media SA
2023
Abstract
Curcumin, an important natural component of turmeric, has been known for a long time for its antimicrobial properties. This study aimed to investigate the anti-biofilm action of the niosome-encapsulated curcumin and explore the involved anti-biofilm mechanism. In silico investigations of ADME-Tox (absorption, distribution, metabolism, excretion, and toxicity) were first performed to predict the suitability of curcumin for pharmaceutical application. Curcumin showed low toxicity but at the same time, low solubility and low stability, which, in turn, might reduce its antimicrobial activity. To overcome these intrinsic limitations, curcumin was encapsulated using a biocompatible niosome system,...