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Developing A Qualitative Model For Evaluation Of Effectiveness Of R&D Projects
, M.Sc. Thesis Sharif University of Technology ; Kermavshah, Ali (Supervisor)
Abstract
Globalization and high rate development in all categories of scientific fields have become a very substantial motive to make effort in R&D affairs all over the world. Therefore, the high volume of investment in this area and Also the importance and urgency of R&D according to economical development statistics and its mutual and close relation with it specially in context of Iran, it is necessary to establish an effective tool to recognize gaps and bugs of subsystems working in the area using high volume investment so as to improve the position of each section of the total body of industry in this regard.
Probabilistic Analysis of Soil-Structure Interaction Effects on Seismic Performance of Structures
, M.Sc. Thesis Sharif University of Technology ; Ghannad, Mohammad Ali (Supervisor) ; Mahsouli, Mojtaba (Supervisor)
Abstract
This thesis studies the effect of soil-structure interaction on the seismic performance of structures with due account of uncertainties. The motivation for this study stems from the significant uncertainty in the earthquake ground motion and in the properties of the soil and the nonlinear behavior of the structure. The soil-structure system is modeled by the sub-structure method. The uncertainty in the properties of the system is described by random variables that are input to this model. Monte Carlo sampling is employed to compute the probability distribution of responses that describe the seismic performance of the structure, such as the ductility demand. In each sample, a randomly...
Quantification of in Vitro Drug Effects on COVID-19 through Analysis of Cellular Morphological Features
, M.Sc. Thesis Sharif University of Technology ; Rohban, Mohammad Hossein (Supervisor) ; Sharifi Zarchi, Ali (Supervisor)
Abstract
The epidemic of Covid 19 has killed millions of people worldwide. Despite the efforts of scientists around the world, there is still no cure for this disease. Approval of newly designed drugs due to clinical trial periods is time-consuming and costly. For this reason, in the current emergency situation, it is important to have a solution for screening available approved drugs in order to find effective substances for this disease.High-throughput assays are a good option for such problems. In this field of research, image-based high-throughput assays are amongst the most effective and cost-effective methods that help quantify the response of treated cells by measuring cell...
Representation Learning for Heterogeneous Information Networks
, M.Sc. Thesis Sharif University of Technology ; Beigy, Hamid (Supervisor)
Abstract
Around world and the networks within it can be modeled in various templates. Graph structure is one of those templates in which objects and relations may have more than one types. We call this phenomenon "heterogeneity".Heterogeneity makes the networks hard to model and that is why the proposed methods for modeling the networks assumed the network structures homogeneous. This assumption may cause data loss due to ignoring the variety of types in network objects and relations and this loss can lessen the accuracy of data mining tasks.To tackle the challenge of data loss in the mentioned assumption, learning representations for heterogeneous information networks (HINs) was introduced. HINs...
Trust modeling based on Capra cognitive framework
, Article Procedia - Social and Behavioral Sciences ; Volume 32 , 2012 , Pages 197-203 ; 18770428 (ISSN) ; Fesharaki, M. N ; Daneshgarb, A ; Sharif University of Technology
2012
Abstract
Trust is needed to facilitate cooperation and delegation among agents in a multi-agent system. This paper proposes a trust model based on Capra cognitive framework. This framework explains social phenomena from the four perspectives of structure (agent), pattern (network), process, and meaning. We assume trust as "meaning" in the proposed model. Every agent has properties such as personality, responsibility, and specialty. Interaction among agents is based on friendship network. OODA, as a general process for decision making, is used for updating the trust in the simulation run
Probabilistic analysis of soil-structure interaction effects on the seismic performance of structures
, Article Earthquake Engineering and Structural Dynamics ; Volume 46, Issue 4 , 2017 , Pages 641-660 ; 00988847 (ISSN) ; Mahsuli, M ; Ghannad, M. A ; Sharif University of Technology
2017
Abstract
This paper revisits the phenomenon of dynamic soil-structure interaction (SSI) with a probabilistic approach. For this purpose, a twofold objective is pursued. First, the effect of SSI on inelastic response of the structure is studied considering the prevailing uncertainties. Second, the consequence of practicing SSI provisions of the current seismic design codes on the structural performance is investigated in a probabilistic framework. The soil-structure system is modeled by the sub-structure method. The uncertainty in the properties of the soil and the structure is described by random variables that are input to this model. Monte Carlo sampling analysis is employed to compute the...
Evaluation of the Impact of Changes in Properties of Crude Oil on Technical Features of Petroleum Supply Chain
, M.Sc. Thesis Sharif University of Technology ; Saboohi, Yadollah (Supervisor)
Abstract
Energy system of each country include of extraction, processing, conversion, transportation and distribution levels. Crude oil is one of the energy carrier which has dominant share to meet energy demand in industry and transportation sectors. Therefore, studying of physical properties changes of this energy carrier during production period is obligatory. The goal of this research is to model quality reduction of crude oil during production period of naturally occurring reservoirs. In this research quality of crude oil has been investigated inside of reservoir and after production and the effect of quality changes in before mentioned conditions according to cumulative production of reservoirs...
Dynamic Analysis of an Inclined Functionally Graded Timoshenko Beam on Viscoelastic Foundation under Moving Mass
, M.Sc. Thesis Sharif University of Technology ; Firouzbazsh, Keykhosrow (Supervisor) ; Asghari, Mohsen (Supervisor)
Abstract
In this study, the linear dynamic response of an inclined FGM Timoshenko beam on linear viscoelastic foundation subjected to a traveling mass with constant and variable velocity is investigated. Timoshenko beam theory and von-karman strain-displacement relations are utilized to model the problem. the FGM beam is made of metal and ceramic and it is assumed that material properties of the beam vary continuously in the thickness direction according to the exponential law and the power-law form. The kelvin-voigt damping model is applied to model the internal damping of the FGM beam. The partial differential equations of motion for the bending rotation of cross-section, longitudinal and...
Solar generated steam injection in HAMCA, Venezuelan extra heavy oil reservoir; Simulation study for oil recovery performance, economical and environmental feasibilities
, Article EUROPEC 2015, 1 June 2015 through 4 June 2015 ; 2015 , Pages 1176-1202 ; 9781510811621 (ISBN) ; Ayatollahi, S ; Bashtani, F ; Romero, C ; Sharif University of Technology
Society of Petroleum Engineers
2015
Abstract
Application of solar energy compared to conventional gas-burning boilers for steam generation in thermal Enhanced Oil Recovery processes is a newly attended technology, which brings significant benefits to the petroleum industry through environmental and economical aspects. This technique is especially designed for the regions in which gas-burning steam generation is not viable in large scale. The objective of this study is to investigate about viability of using solar energy to generate steam instead of using conventional steam generators in a Venezuelan extra heavy oil reservoir. Limited gas production policy of the Venezuelan government is the major challenge for utilizing gas steam...
Font recognition for Persian optical character recognition system
, Article Iranian Conference on Machine Vision and Image Processing, MVIPVolume 2017-November, 19 April 2018 ; Volume 2017 -November , April , 2018 , Pages 252-257 ; 21666776 (ISSN) ; 9781538644041 (ISBN) ; Veisi, H ; Mirzaie, M ; Mohseni Behbahani, Y ; Sharif University of Technology
IEEE Computer Society
2018
Abstract
Font recognition is one of the pre-processing steps in optical character recognition (OCR) systems that affects on their performance. In this paper two methods are proposed for Persian font recognition. In the first method, Gabor filter is used for feature extraction from the images, then principle component analysis (PCA) applied to reduce feature dimensions and finally, a multi-layer Perceptron (MLP) neural network is used for the classification. In the second techniques, random forest is utilized for recognizing fonts. For evaluation, a dataset includes 10 popular Persian fonts is used. The proposed Gabor-PCA-MLP method has achieved 98.70% of F-measure, and random forest resulted in of...
Optimization and characterization of tannic acid loaded niosomes for enhanced antibacterial and anti-biofilm activities
, Article Advanced Powder Technology ; 2020 ; Akbarzadeh, I ; Nourouzian, D ; Mirzaie, A ; Bakhshandeh, H ; Sharif University of Technology
Elsevier B.V
2020
Abstract
The purpose of this study was to prepare and characterize an optimized system of tannic acid-loaded niosomes as a potential carrier for antibacterial and anti-biofilm delivery. The niosomal formulation was optimized using response surface methodology (RSM). The effects of the molar ratio of surfactant to cholesterol, drug concentration, and molar ratio of Span 60 to Tween 60 on particle size and drug entrapment efficiency of the niosomal nanocarrier were studied. The optimized nanoparticles were characterized in terms of the morphology, in vitro release profile, and antibacterial properties. Moreover, Fourier-transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC)...
Improved Distinguisher-Based Cryptanalysis of Block Ciphers
, M.Sc. Thesis Sharif University of Technology ; Aref, Mohammad Reza (Supervisor) ; Ahmadi, Siavash (Co-Supervisor)
Abstract
With the continuous development of networks and communication technologies, security evaluation of cryptographic primitives, including block ciphers, which serve as the foundation for securing numerous communication protocols in these networks and technologies, has become more crucial than ever before. Inadequate security at block ciphers endures a risk to the overall security architecture of a system. Therefore, significant attention has been devoted to the development of methods for breaking and evaluating the security of block ciphers, known as cryptanalysis. In this thesis, we investigate division property-based integral cryptanalysis, which is one of the latest distinguisher-based...
Comparing different scenarios for thermal enhanced oil recovery in fractured reservoirs using hybrid solar-gas steam generators, a simulation study
, Article Society of Petroleum Engineers - SPE Europec Featured at 78th EAGE Conference and Exhibition, 30 May 2016 through 2 June 2016 ; 2016 ; 9781613994573 (ISBN) ; Bashtani, F ; Tahmasebi, A ; Ayatollahi, S ; Al Wahaibi, Y. M ; Sharif University of Technology
Society of Petroleum Engineers
2016
Abstract
The application of the renewable energy sources, especially solar energy, for thermal enhanced oil recovery methods as an economical and environmental valuable technique has received many attractions recently. Concentrated Solar Power systems are capable of producing substantial quantities of steam by means of focused sunlight as the heat source for steam generation. This paper aims to investigate viability of using this innovative technology in fractured reservoirs to generate steam instead of using conventional steam generators. A synthetic fractured reservoir with properties similar to those of giant carbonate oil reserves in the Middle East was designed by using commercial thermal...
Efflux pump inhibitory activity of biologically synthesized silver nanoparticles against multidrug-resistant Acinetobacter baumannii clinical isolates
, Article Journal of Basic Microbiology ; Volume 60, Issue 6 , 2020 , Pages 494-507 ; Pargol, M ; Mirzaie, A ; Karizi, S. Z ; Noorbazargan, H ; Akbarzadeh, I ; Sharif University of Technology
Wiley-VCH Verlag
2020
Abstract
This study was carried out to investigate the possible efflux pump inhibitory activity of biologically synthesized silver nanoparticles (AgNPs) against multidrug-resistant (MDR) Acinetobacter baumannii isolates. In this study, the physicochemical characteristics of synthesized AgNPs were investigated using scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), and Fourier transform infrared spectrophotometer (FTIR) methods. Subsequently, MDR A. baumannii isolates were recovered from clinical samples and the phenotypic cartwheel efflux assay and polymerase chain reaction (PCR) were used to elucidate the possible presence of efflux pump in MDR...
Streptomycin sulfate–loaded niosomes enables increased antimicrobial and anti-biofilm activities
, Article Frontiers in Bioengineering and Biotechnology ; Volume 9 , 2021 ; 22964185 (ISSN) ; Khayam, N ; Jamshidifar, E ; Pourseif, T ; Kianian, S ; Mirzaie, A ; Akbarzadeh, I ; Ren, Q ; Sharif University of Technology
Frontiers Media S.A
2021
Abstract
One of the antibiotics used to treat infections is streptomycin sulfate that inhibits both Gram-negative and -positive bacteria. Nanoparticles are suitable carriers for the direct delivery and release of drug agents to infected locations. Niosomes are one of the new drug delivery systems that have received much attention today due to their excellent biofilm penetration property and controlled release. In this study, niosomes containing streptomycin sulfate were prepared by using the thin layer hydration method and optimized based on the size, polydispersity index (PDI), and encapsulation efficiency (EE%) characteristics. It was found that the Span 60-to-Tween 60 ratio of 1.5 and the...
Folate conjugated hyaluronic acid coated alginate nanogels encapsulated oxaliplatin enhance antitumor and apoptosis efficacy on colorectal cancer cells (HT29 cell line)
, Article Toxicology in Vitro ; Volume 65 , 2020 ; Zare Karizi, S ; Safaie Javan, R ; Mirzaie, A ; Noorbazargan, H ; Akbarzadeh, I ; Rezaie, H ; Sharif University of Technology
Elsevier Ltd
2020
Abstract
Oxaliplatin (OXA) has been widely used for treatment of colorectal cancer. In this study, to enhance antitumor and apoptosis efficacy, OXA was encapsulated in a novel folate conjugated hyaluronic acid coated alginate nanogels (F/HA/AL/OXA). The F/HA/AL/OXA nanogels were prepared by cross-linking process. The physico-chemical properties of F/HA/AL/OXA nanogels were characterized using scanning electron microscopy, transmission electron microscopy, fourier transform infrared spectroscopy, dynamic light scattering, and fluorescent spectrophotometry. The in-vitro antitumor activity of free OXA, AL, HA/AL, HA/AL/OXA and F/HA/AL/OXA nanogels were assessed using MTT assay against colorectal cancer...
Preparation and optimization of ciprofloxacin encapsulated niosomes: A new approach for enhanced antibacterial activity, biofilm inhibition and reduced antibiotic resistance in ciprofloxacin-resistant methicillin-resistance Staphylococcus aureus
, Article Bioorganic Chemistry ; Volume 103 , October , 2020 ; Peirovi, N ; Akbarzadeh, I ; Moghtaderi, M ; Heidari, F ; Yeganeh, F. E ; Noorbazargan, H ; Mirzazadeh, S ; Bakhtiari, R ; Sharif University of Technology
Academic Press Inc
2020
Abstract
Ciprofloxacin is an alternative to vancomycin for treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections. The objective of this study was to optimization of niosomes encapsulated ciprofloxacin and evaluate their antibacterial and anti-biofilm efficacies against ciprofloxacin-resistant methicillin-resistant S. aureus (CR-MRSA) strains. Formulation of niosomes encapsulated ciprofloxacin were optimized by changing the proportions of Tween 60, Span 60, and cholesterol. The optimized ciprofloxacin encapsulated niosomal formulations based on Span 60 and Tween 60 were prepared and characterized using scanning electron microscopy (SEM), transmission electron microscopy (TEM) and...
Technical English for mechanical engineers
, Book ; Meghdari,Ali
Sharif University Press
2014
Abstract
Local educational institutions produce in-house English for Specific Purpose (ESP) materials according to the curriculum policies designated and developed by the Ministry of Higher Education In Iran. To this end, this book aims to be used in the Iranian setting at the tertiary level for undergraduate students majoring in Mechanical Engineering. Moreover, the style of English usage in this ESP textbook is American.
Regarding the content of the textbook, it has both thematic organizations in which the topics are relevant and includes sufficient treatment of the target language areas necessary for the students. The principle organizing approach of this textbook is theme-based. In addition,...
Regarding the content of the textbook, it has both thematic organizations in which the topics are relevant and includes sufficient treatment of the target language areas necessary for the students. The principle organizing approach of this textbook is theme-based. In addition,...
Feedback control of the neuro-musculoskeletal system in a forward dynamics simulation of stair locomotion [electronic resource]
, Article Proc. of IMechE Part H: Journal of Engineering in Medicine ; 2009, Vol. 223, No. 6, pp. 663-675 Journal of NeuroEngineering and Rehabilitation ; Volume 11, Issue 1, 30 April 2014, Article number 78 ; Meghdari, Ali ; Vossough, Gholam Reza ; Sharif University of Technology
Abstract
The aim of this study is to employ feedback control loops to provide a stable forward dynamics simulation of human movement under repeated position constraint conditions in the environment, particularly during stair climbing. A ten-degrees-of-freedom skeletal model containing 18 Hill-type musculotendon actuators per leg was employed to simulate the model in the sagittal plane. The postural tracking and obstacle avoidance were provided by the proportional—integral—derivative controller according to the modulation of the time rate change of the joint kinematics. The stability of the model was maintained by controlling the velocity of the body's centre of mass according to the desired centre of...
Design and Construction of a Soft Actuated Exoskeleton for Hand Rehabilitation of Stroke Patients
, M.Sc. Thesis Sharif University of Technology ; Ghafari, Ali (Supervisor) ; Meghdari, Ali (Supervisor)
Abstract
The main goal of this thesis is the design and development of a rehabilitation device for helping patients “to improve blood circulation” & retain and recover their abilities if possible that were lost during the stroke or a accident like that (my research in karaj/iran shows that it is possible by just movement of the specific body part). The focus is on hand in this thesis because Injuries to the hand are common and can be very debilitating since our hands are our primary means for interacting with our world. For rehabilitation in case of human hand there are several practices that should be done for patients either in home or in a rehabilitation center, time and money that is supposed to...