Sharif Digital Repository

Using the cross docking is a strategy that plays inventory coordinating role in the supply chain. At the cross docking, products of inbound trucks are unloaded, sorted, moved and loaded onto outbound trucks for delivery to different destinations. In this concept, coordination between inbound and outbound trucks considering a cross-dock system with multiple receiving and shipping dock doors. Moreover, due to justifiability of all trucks to carry multiple product types, product assignment from inbound trucks to outbound trucks is determined simultaneous to scheduling. As an exact solution approach a MIP model is presented and since the problem is shown to be NP-hard, it can only be used to... 

The aim of this research is to develop a smart mesoporous bioactive glass-based carrier for targeted drug delivery to cancer cells, particularly bone cancer cells. To achieve this, mesoporous bioactive glass nanoparticles were first synthesized, followed by surface modification with amine groups. To prevent premature drug release before reaching the target tissue and to introduce pH sensitivity, the nanoparticle pores were coated with oxidized hyaluronic acid via Schiff-base bonding with the amine groups on the surface. The use of hyaluronic acid facilitates active targeting of CD44 receptors, which are overexpressed on the surface of cancer cells compared to healthy cells. This process... 

The present work describes sensing application of modified Pt nanostructures towards detection of glucose. Modified Pt nanostructured electrodes were prepared using electrodeposition method such as chronoampermetry and potentiostatic pulse methods. The electrodeposition of Pt nanostructures was first studied by voltammetry and amperommetry techniques and then potentiostatic pulse method has been used to produce the alloyed structures of platinum. In this regard, the first electrode was proposed based on alloyed Pt/Ni nanowire arrays (NWAs) for the non-enzymatic detection of glucose. The Pt/Ni NWAs were prepared by pulse electrodeposition of Pt and Ni within a nano-pore polycarbonate (PC)... 

Any physical system is characterized with some set of quantities or parameters, knowing which, is equivalent to estimation of the system. Evaluating such parameters is usually done using tomography methods. An important question to ask, is how to increase the precision of measurement, being able to do some specific set of physical operations, say, measurement?
this question is more important in parameter estimation in quantum meanical systems. It has been shown that, quantum meanics causes a fundamental limit, on precision of estimating su parameters, escribed by the so called “antum Cramér-Rao bound”.We must note that almost all quantum meanical systems are interacting with the... 

This thesis provids a Persian End-To-End Speech Recognition system. In this system, the input is low-level features of speech signal. Deep recurrent neural networks (RNNs) and Long Short-Term Memory (LSTM) units as the RNN building blocks are used as the acoustic model. Continuous speech data is labeled by the CTC which is applied as the output layer of a recurrent neural network. By using the CTC objective function, acoustic modeling problem is simplified to just an RNN learning problem over pairs of speech and context-independent (CI) label sequences. A distinctive feature of this system is a generalized decoding approach based on weighted finite-state transducers (WFSTs), which enables... 

The aim of this project is to load analgesic drug; Paracetamol on dental implant. The implant is titanium alloy (Ti-6Al-4V). There are two kinds of samples of anodized and HA coated onto anodized. They are in the shape of the sheets in this study. The electrodeposition and anodization carried out in order to treat the two samples. Nanotubes were formed during anodic oxidation of the samples in the 1M Ammonium sulfate (NH₄)₂SO4 and 5wt% Ammonium fluoride NH4F electrolyte. They are expected to play role of carrier for the model drug; paracetamol. The results showed that HA anodized Ti-6-4 has the ability to hold higher amounts of drug and also can keep the drug for a longer time than the... 

Temerature fluctuation of the Cosmic Microwave Background (CMB) is one of the key observebles of the modern cosmology. Today, it is widely believed that quantum fluctuation that are stretched to horizon scales during a period of acceleration expansion -- at the onset of evolution of the universe-- are responsible for these perturbations. In the simplest scenarios of the inflation, a scalar field is responsible for both nearly expansional expansion of the universe and the proimordial fluctuations. In this thesis, we investigate the models of inflation with an additional light degree of freedom. In particular, we employ the method of the Effective Field Theory to study the general structure... 

There are lots of researches performed to investigate human being learning and try to model it. But, in case of huge complexity of its structure and function, almost none of so-far learning algorithms can model human learning process and, indeed, performance of human brain in real problems is much more than these algorithms. Moreover, in many cases, human is not aware or informed about internal structure or mathematical model of the present system he is working on; a child learning to walk has no information about his neuromuscular system and his brain slowly learns how to convey his little body by choosing the proper timing of muscle contractions. One of the accomplished researches in order... 

Emergence of crypto-currency and blockchain technology revolutionize supply chain processes. In addition, customer needs for more information on products or services from origin to destination, highlights the necessity of transparency, originality and traceability in supply chains. This research is aimed to develop a blockchain based system ascertaining supply chain transparency and originality. To this aim, a joint pricing and closed-loop supply chain network design problem is selected as a good platform to implement it. Due to increasing concerns on environmental issues and maximizing job opportunities, sustainability is also considered in the proposed problem. To ascertain transparency... 

In this study, chitosan-based nanoparticles were prepared due to their biocompatibility, availability, high loading capacity of drug, stimulus responsive behavior and the presence of active functional groups. Chitosan was chemically functionalized with reactive oxygen species (ROS)-responsive moiety to respond to the oxidative stess and endosomal pH in nerve injuries. To prepare nanoparticles, functinalized chitosan ionically gelated with pH-responsive polyanions with ROS-scavenging properties such as polyacrylic acid and hyaluronic acid. Then, pH- and ROS-responsive nanoparticles were used for selective transfection into reactive astrocytes and axonal regeneration in spinal cord injuries....