Sharif Digital Repository

Single Cell RNA sequencing (scRNA-seq) data provides more information about gene expression at cellular level. However, because of noise and sparsity that exist in scRNA-seq data, analysis of this data has faced to obstacles. Global normalization approach can not resolve correctly missing data that come from technical variability. So this approach cause emerging incorrect bias and dishonest conclusion about cell type. In this study we review some models for scRNA-seq data imputation,explain a new method for filtering genes and clustering data and use matrix completion algorithm for imputation data  

Rapid growth of technology and the increase in availability of fast communication means caused transportation planners to pay attention to solutions of demand management with an aproach to information technology. Replacement of traditional shopping with internet shopping can be seen as a suitable solution to reduce traffic and polution. Purpose of this research is to probe teleshopping choice and the frequency of doing that, simultaneously, using copula model as the most common aproach of joint models in recent years. In this research, the binary logit model is used to build the model for teleshopping choice and the order logit model is used to build the frequency model. The data sample is... 

Quality of Experience (QoE) indicates the overall quality of one service such as Voice over IP (VoIP) from users' point of view by considering several systems, human, and contextual factors. QoE measurement and prediction are more challenging than Quality of Service (QoS) which is only related to network parameters. There exist various objective and subjective methods for QoE prediction. This research investigates various features affecting QoE by proposing a comprehensive subjective evaluation by employing a large number of users. We show that many unconsidered factors including speaker specifications and signal properties, such as signal-to-noise ratio (SNR), can affect QoE so that the SNR... 

Phenolic compounds are hazardous pollutants that are released into environment through wastewater discharges from variety of industries. Although good biodegradability has been reported at low concentrations, but at higher concentrations phenols are known to be antibacterial. In this study the Membrane Biological Reactor (MBR) with submerged hallow fiber membrane was operated at 25±2 ºC and pH=7.5±0.5 to treat a synthetic wastewater containing high phenol concentration (up to 5.9 g/l). Removal efficiency of phenol and COD were evaluated at four various “Hydraulic Retention Times” (HRT) of 24, 12, 8 and 4 hours. To test the tolerance of the bioreactor to phenol concentration various loading... 

Many simulation optimization problems are defined in random settings and their inputs have uncertainty. Therefore, in defining an optimal solution for these problems, uncertainties should be taken into account. The primary way of dealing with this , is Robust Optimization which finds solution immune to these changing settings. Aiming at finding a new approach for simulation optimization problems, this study investigates these uncertainties and robust methods. In the optimization problem, the goal and constraints are considered with separate risk measures and a related problem is defined as follows: Minimizing the weighted sum of all risks subject to the problem constraints. To solve the... 

One of issues of human in this time is questions about epistemology. Human sometimes faced with this qustion that "Is it any knowledge for human being". Sometime he or she answers this question: yes and search for any knowledge around him or her. In the context of philosophy of science these question are very imortant. In philosophy of science one of major question is how many of factors in science is subjective and how many is objective? It is obvious that one of solution to answer this question is investigation of factors that construct the knowledege. Furthermore in this thesis I try to answer that question in context of Hikmat' Motealieh. In this context all of factors that involved in... 

Wireless Sensor Networks (WSNs) consist of sensor nodes that are connected to each other and are widely used in many applications to acquire and process information. WSN nodes are battery powered, therefore energy management is a key factor for long live network. Node radio transceiver unit uses the most part of energy resource of the node and as a result limits the network lifetime. One way to prolong lifetime of network is to utilize routing protocols to manage energy consumption. To have an energy efficient protocol, we can apply cluster organization on the network, where sensor nodes are partitioned into groups called cluster. Then, the whole cluster data is sent through Cluster Head... 

During years, supersymmetry has been a candidate for resolution of Higgs mass fine-tuning problem that is quadratic dependence of scalar mass radiative correction to UV-physics. So, supersymmetry phenomenology is of great importance. As accelerators have reached energy of 13 TeV in recent years and sparticles have not yet been observed, it is important to have a theory in hand, describing SUSY breaking dynamics with scale of SUSY breaking above the energies currently accessible to accelerators. As a result of mass-sum-rule constraint which holds in theories with spontaneous SUSY breaking at tree level and leads to light sparticles and even tachyonic directions, there are currently no... 

Biomechanical models require body posture to evaluate the risk of musculoskeletal injuries during daily/occupational activities like manual material handling (MMH). The procedure to measure body posture via motion-analysis techniques is complex, time-consuming, and limited to equipped laboratories. This study aims to develop an easy-to-use yet accurate model that predict human whole-body static posture (3D body coordinates and anatomical joint angles) during different MMH activities. Twenty healthy male right-handed individuals with body mass index between 18 and 26 performed 204 symmetric and asymmetric MMH activities. Each person reached (i.e., without any load in hands) the destinations... 

In recent years, Additive Manufacturing has been extensively used by various industries. These manufacturing processes produce components in a layer-by-layer manner; therefore, they do not impose any geometric constrains to engineers and provide designers with the freedom to design components. Nowadays, one of the primary goals of all industries is to utilize as few raw materials as possible; this way they can deal with the shortage of raw materials and improve their efficiency. Consequently, they implement topology optimization algorithms to design and produce their components. However, topology optimization algorithms result in complicated geometries that can only be fabricated by AM.... 

The problem of developing optimal pricing and inventory allocation strategies has been extensively studied over the past two decades. However, most of the literature in this area assumes that customers are myopic price-takers, and do not respond to firm pricing strategically. In this study, we present review on a class of problems that consider a firm selling a finite number of items over a finite time horizon facing stochastic demand and a group of customers who act strategically by timing their purchases. We first review the optimal purchasing policy for the customers, and pricing policy for the firm that is the best response policy to the customer’s strategic behavior. Then we present a... 

In many applications in human society, there is a need for identity recognition of people.Different methods have been developed for this purpose while using the biometrics is one of the major interests. The biometrics measure the unique physiological, anatomical and behavioural characteristics of people. Among them, face is an interesting biometric which have important advantages over other biometrics and face recognition is known as the most common method that people utilize to recognize each other. However, face recognition suffers from factors such as changes in head pose, illumination and face expression which influence the efficiency of recognition methods. The core of many recent... 

The interaction of the vortices and helicopter’s blades is the most significant source of generating the main rotor’s noise, especially in landing and rising. The kind of this noise is broadband and it is produced because of establishing the vortices behind the forward blade, their interaction with backward blade, changing their structures and creating turbulency loading. The known method for modeling of the interaction of the vortices structures and solid surfaces is the simple compounding the rod and airfoil. In this project, by using this method, the noise of the interaction of vortex and blade is modeled in the Reynolds number of 48000 with LES and FW-H Analogy as a hibrid method in...