Dose Simulation in Different Body Parts in Radiotherapy Using Fluka Monte Carlo Code on Human Phantom and Benchmarking with TL Dosimetry

, M.Sc. Thesis Sharif University of Technology Montazam, Mahnaz (Author) ; Sohrabpour, Mostafa (Supervisor) ; Mahdavi, Rabi (Supervisor)

Abstract

Radiation therapy is a treatment modality that is used in treatment of most newly diagnosed cancer patients. In this method the interaction of radiation with matter and their biological effects is used for cancer treatment. The energy and intensity of the radiation in radiotherapy should be considered in order to have a lethal effect on tumors. Linear accelerators are substitutes for previous methods of radiotherapy in all over the world. These machines can work in both electron and photon mode. The Monte Carlo technique has become ubiquitous in medical physics in the last 50 years. The range of applications is very broad in medical physics. The increased use of Monte Carlo techniques is...

Production of drug Loaded Microgels Using Microfluidic

, M.Sc. Thesis Sharif University of Technology Mehraji, Sima (Author) ; Saadatmand, Maryam (Supervisor) ; Eskandari, Mahnaz (Supervisor)

Abstract

Microfluidic systems have the ability to produce microgels with uniform size distribution and spherical shape due to the laminar flow and better control of the flow rates. Spherical microgels with same size can be used as high-potential carriers for drug release. An important challenge in the production of these drug-carrying microgels is the simultaneous process of drug loading into microgels and their production. The overall goal of this project was to produce drug-carrying microgels with uniform size distribution that show controlled drug release. To achieve this goal, various factors such as the type of polymer, the type of drug, the volume ratio of the polymer and the drug and the...

Design and Fabrication of Microfluidic System to Produce Microgel for Drug Delivery Application

, M.Sc. Thesis Sharif University of Technology Shieh, Hamed (Author) ; Bastani, Dariush (Supervisor) ; Saadatmand, Maryam (Supervisor) ; Eskandari, Mahnaz (Supervisor)

Abstract

Due to the increasing need of use of drugs and insufficient efficiency of conventional methods, drug delivery systems has gathered a lot of interests. There are different systems existing for controlled drug delivery, among which is implementation of hydrogel microparticles (microgels) as carriers with high potential. The most important factor in these systems is size distribution of drug-carrying microgels and a narrow size distribution leads to a controlled and suitable release. Due to unique characteristics of microfluidic systems, significant focus has been placed on them nowadays for production of microgels with suitable morphology and narrow size distribution. Therefore, in this study...