Sharif Digital Repository

The cold dark matter (CDM) paradigm has been successful in explaining large-scale structure formation in the universe, yet it faces significant challenges on length scales smaller than 1 Mpc and mass scales smaller than 1011 MꙨ. So the search for alternative models is ongoing. In this work, we investigate a novel dark matter model based on the dark gravitons in the Dark Dimension scenario, inspired by the Swampland program. We begin by discussing the theoretical underpinnings of the Dark Dimension scenario and how it modifies the properties of dark matter. We then calculate the growth function of matter perturbations in the linear regime, establishing the groundwork for understanding the... 

The cold dark matter (CDM) paradigm has been successful in explaining large-scale structure formation in the universe, yet it faces significant challenges on length scales smaller than 1 Mpc and mass scales smaller than $ 10^{11}\ M_\odot$. So the search for alternative models is ongoing. In this work, we investigate a novel dark matter model based on the dark gravitons in the Dark Dimension scenario, inspired by the Swampland program. We begin by discussing the theoretical underpinnings of the Dark Dimension scenario and how it modifies the properties of dark matter. We then calculate the growth function of matter perturbations in the linear regime, establishing the groundwork for... 

The purpose of this study is to assess the inhibitory effects of an appropriate nanoparticles loaded with gallic acid on the fibrillation of alpha-synuclein. Alpha-synuclein is a major component of protein plaques in synucleinopathies, particularly Parkinson’s disease. Gallic acid (GA, 3,4,5-trihydroxy benzoic acid) is a well–known small molecule which can inhibit the formation of α-synuclein fibrils. For the process of fibrillation, purified protein was incubated at 37◦C and pH 7.2. Fibrillation was analyzed by the standard fibril methods.after that investigated fabricating of gallic acid trapped in the chitosan nanoparticles and gallic acid loaded in chitosan –coated mesoporous silica... 

This research aims to develop a drug delivery system based on mesoporous silica nanoparticles (MSNPs) for hydrophobic drugs and evaluating their cytotoxicity. The internal environment of the body is aqueous, while most of effective drugs display poor aqueous solubility, resulting in insufficient bioavailability. Due to their several unique properties, such as a large surface area, tunable pore size, facile surface multi functionalization and excellent biocompatibility, MSNPs are recognized as promising and powerful tools to overcome this hurdle. In the present study, MSNPs were synthesized using template removing method and then were functionalized through grafting procedure. They were...