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Productivity Improvement in Mashhad Wheel Manufacturing Company
, M.Sc. Thesis Sharif University of Technology ; Mostofi (Supervisor)
Abstract
The present study, which is about practical methods of improving productivity in Mashhad ring factory, is presented in five chapters. In the foreword, the need for an attitude to improve productivity at the national level as well as in industry has been mentioned and has laid the groundwork for starting a discussion of productivity and practical solutions to improve it. In the first chapter, by defining productivity, considers the different perceptions of societies about productivity and finally deals with misconceptions about the concept of productivity. In the second chapter, based on committed articles from the American Society of Industrial Engineering, discusses the role of industrial...
An Efficient Data Prefetching Scheme in GPUs
, M.Sc. Thesis Sharif University of Technology ; Sarbazi Azad, Hamid (Supervisor)
Abstract
GPUs exploit memory hierarchy and thread-level parallelism (TLP) to hide off-chip memory access delay. However, GPUs can not keep TLP high during the execution of various applications, and hence, they fall short of hiding the access delay to off-chip memory. One effective approach to reducing memory access delay is prefetching. Prior research shows the positive impact of prefetching in improving the performance of GPUs. However, they fail to capture all the potential behind the prefetching in GPUs. In this thesis, we propose Snake, a new data prefetching in GPUs. Snake identifies stride distances among different memory access instructions and prefetches a chain of addresses that will be...
Comparative study of commercial media to improve GMP manufacturing of recombinant human interferon β-1a by CHO cells in perfusion bioreactor
, Article Cytotechnology ; Volume 74, Issue 6 , 2022 , Pages 669-680 ; 09209069 (ISSN) ; Karimi Mostofi, R ; Sattarzadeh, A ; Shahbazi, M ; Aghazadeh, H ; Sharif University of Technology
Springer Science and Business Media B.V
2022
Abstract
Chinese hamster ovary cells are the main cellular factories for production of a wide range of recombinant proteins in biopharmaceutical industry. Recombinant human Interferon beta-1a (rh-IFN β-1a), as a cytokine is broadly used to treat multiple sclerosis. In this work, the cell line producing rh-IFN β-1a was studied to improve cell density along with the specific expression. For this reason different cell culture experiments were done using different commercial serum-free media to find the appropriate media providing higher cell density. It was shown DMEMF12, DMEM:ProCHO5, and CHO-S-SFM II led to higher cell density and shorter doubling time. Next, using these media, fed-batch, and...
High-titer recombinant adenovirus 26 vector GMP manufacturing in HEK 293 cells with a stirred single-use bioreactor for COVID-19 vaccination purposes
, Article ACS Omega ; Volume 8, Issue 40 , 2023 , Pages 36720-36728 ; 24701343 (ISSN) ; Sattarzadeh, A ; Karimi Mostofi, R ; Dinarvand, B ; Nazarpour, M ; Sharif University of Technology
American Chemical Society
2023
Abstract
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 virus) pandemic has shown the importance of pursuing various vaccine manufacturing strategies. In the present study, the HEK 293 cells were infected with recombinant adenovirus serotype 26 (rAd26), and the effects of critical process parameters (CPPs) including viable cell density (VCD) at infection time (0.5 × 106, 0.8 × 106, 1.4 × 106, 1.8 × 106, and 2.5 × 106 cells/mL), the multiplicity of infection (MOI) = 3, 6, 9, 12, and 15, and two aeration strategies (high-speed agitation with a sparging system and low-speed agitation with an overlay system) were investigated experimentally. The results of small-scale experiments in 2 L...