Sharif Digital Repository

In this study, the effect of submerged vanes on the flow pattern and dimensions of separation zone at a 90˚ open-channel Junction were investigated. The experiments were conducted in three stages. First, for validity of data with the results of webber et al, using ADV, velocities was teken without submerged vanes.in the second stage, experiments with dye injection was performed at confluence for several initial arrangement of vanes. From 54 different arrangements, two arrangements were selected. In three stage, three dimensional velocities was teken in two arrangement selected. Due to the significant reduction the size of separation zone in one of these arrangements, with moving this... 

Content-Centric Network is a new network paradigm. In this paradigm, contents are the main element of the network, and the place holding the content is transparent to users. In other words, the concept of content’s place is eliminated. In spite of other common paradigms in which caching operation is occurred in just a few predefined nodes and also it is limited to a specific application, in this kind of network, caching operation can be occurred in all nodes, independent of the application. Furthermore, due to elimination of the concept of the content’s place, matching of same contents held in different places can be possible. So caching in such networks became an important issue. In caching... 

The aim of this research is to develop a smart mesoporous bioactive glass-based carrier for targeted drug delivery to cancer cells, particularly bone cancer cells. To achieve this, mesoporous bioactive glass nanoparticles were first synthesized, followed by surface modification with amine groups. To prevent premature drug release before reaching the target tissue and to introduce pH sensitivity, the nanoparticle pores were coated with oxidized hyaluronic acid via Schiff-base bonding with the amine groups on the surface. The use of hyaluronic acid facilitates active targeting of CD44 receptors, which are overexpressed on the surface of cancer cells compared to healthy cells. This process... 

The present work describes sensing application of modified Pt nanostructures towards detection of glucose. Modified Pt nanostructured electrodes were prepared using electrodeposition method such as chronoampermetry and potentiostatic pulse methods. The electrodeposition of Pt nanostructures was first studied by voltammetry and amperommetry techniques and then potentiostatic pulse method has been used to produce the alloyed structures of platinum. In this regard, the first electrode was proposed based on alloyed Pt/Ni nanowire arrays (NWAs) for the non-enzymatic detection of glucose. The Pt/Ni NWAs were prepared by pulse electrodeposition of Pt and Ni within a nano-pore polycarbonate (PC)... 

Any physical system is characterized with some set of quantities or parameters, knowing which, is equivalent to estimation of the system. Evaluating such parameters is usually done using tomography methods. An important question to ask, is how to increase the precision of measurement, being able to do some specific set of physical operations, say, measurement?
this question is more important in parameter estimation in quantum meanical systems. It has been shown that, quantum meanics causes a fundamental limit, on precision of estimating su parameters, escribed by the so called “antum Cramér-Rao bound”.We must note that almost all quantum meanical systems are interacting with the... 

Formation damage in petroleum engineering is an important and fundamental phenomenon. During drilling operation, penetration of either the solid phase of drilling fluid or the base-fluid into the porous medium, reduces the permeability of the formation. While most experiments in the literature have focused on core-scale and beyond, there is lack of pore-scale studies. Moreover, presence of fractures has an undeniable effect on the extent of formation damage. Thus, the main objective of this dissertation is to investigate the effects of fractures on the severity of formation damage caused by the water-based drilling fluid and the mechanisms of formation damage at the pore scale, using glass... 

F-BAR protein is one of the Bin/Amphiphysin/Rvs (BAR) superfamily proteins which contributes in curvature generation and stabilization of lipid membranes. These proteins usualy form lattices on the membrane and can sculpt the membrane. In this project the interaction of F-BAR protein with a lipid membrane is modeled using coarse grained molecular dynamics approach. In order to describe the curvature generation and stabilization we would need an appropriate coarse grained model for the lipid membrane. In this project the proposed model for the membrane describes a membrane in liquid phase with a lateral diffusion in the lipid bilayer. Depth and width of the lipids potential is determined in... 

In this study, chitosan-based nanoparticles were prepared due to their biocompatibility, availability, high loading capacity of drug, stimulus responsive behavior and the presence of active functional groups. Chitosan was chemically functionalized with reactive oxygen species (ROS)-responsive moiety to respond to the oxidative stess and endosomal pH in nerve injuries. To prepare nanoparticles, functinalized chitosan ionically gelated with pH-responsive polyanions with ROS-scavenging properties such as polyacrylic acid and hyaluronic acid. Then, pH- and ROS-responsive nanoparticles were used for selective transfection into reactive astrocytes and axonal regeneration in spinal cord injuries....