Design and Computational Evaluation of Sugar-Amino Acid Conjugates as CK2α Inhibitor

, M.Sc. Thesis Sharif University of Technology Nonanal Nahr, Milad (Author) ; Fattahi, Alireza (Supervisor)

Abstract

The aim of this study is to devise innovative compounds that impede the function of CK2α enzyme by incorporating amino acids and sugars into their molecular structure. CK2α, a catalytic subunit of CK2 enzyme, operates autonomously and is the only continuously active kinase that does not require an upstream regulator. Emerging evidence highlights CK2α's crucial role in various cancers and infectious diseases, including Covid-19, indicating that suppressing its function could provide a promising approach to improve patient outcomes. To accomplish this objective, the drug design process must take into account both pharmacokinetic and pharmacodynamic properties. Pharmacokinetics, encompassing...

A robust optimization approach for multi-objective, multi-product, multi-period, closed-loop green supply chain network designs under uncertainty and discount

, Article Journal of Industrial and Production Engineering ; Volume 37, Issue 1 , 2020 , Pages 1-22 Ghahremani Nahr, J ; Pasandideh, S. H. R ; Akhavan Niaki, S. T ; Sharif University of Technology

Taylor and Francis Ltd 2020

Abstract

One of the basic requirements of the companies to survive in real-world competitive environments is to make their supply chains as efficient as possible. Due to recent governmental regulations, environmental issues, and the development of the concept of social responsibility, the closed-loop supply chain management has been focused by many researchers. A closed-loop supply chain includes both forward and reverse supply chain networks with the purpose of combining environmental considerations with the traditional supply chain network designs through the collection of used products and activities related to their reuse. In this paper, a bi-objective, multi-period, multi-product, closed-loop...

Does the short-term boost of renewable energies guarantee their stable long-term growth? Assessment of the dynamics of feed-in tariff policy

, Article Renewable Energy ; Volume 159 , October , 2020 , Pages 1252-1268 Milad Mousavian, H ; Hamed Shakouri, G ; Mashayekhi, A. N ; Kazemi, A ; Sharif University of Technology

Elsevier Ltd 2020

Abstract

Feed-in tariff (FiT) is one of the most efficient ways that many governments throughout the world use to stimulate investment in renewable energies (REs) technology. For governments, financial management of the policy could be challenging as it needs a considerable amount of budget to support RE producers during the long remuneration period. In this paper, it has been illuminated that the early growth of REs capacity could be a temporary boost. And the socio-economic structure of the system will backlash the policy if some social mechanisms are not considered. Social tolerance for paying REs tax and potential investors’ trust emanated from budget-related mechanisms -which have rarely been...