Sharif Digital Repository

A drug can be defined as a substance made to prevent disease, cure a specific symptom, relieve pain, and reduce anomalies in the body. The process of drug designing is so laborious, complex, costly, and time-consuming that chance of failure during the lab experiment stages is high. These challenges have persuaded researchers to find new usage for existing drugs, referred to as drug repurposing, with the main advantage of reducing cost, risk, and time. To this aim, computational methods have been applied to discover hidden pharmaceutical capabilities of drugs in terms of predicting whether a particular drug can interact with a particular protein.Graph Neural Networks (GNNs) have recently... 

As part of the definition of concept drift as an online learning task, concepts change or drift as time goes by. Consequently, these changes have to be monitored and their implication for learning should be recognized. An example of concept drift detection is needed for spam filtering problem. An effective spam filter must be able to handle various changes, including changes in the user’s criteria for filtering spam, changes in message topics, and changes caused by the people sending spam messages. In this thesis, spam detection system has been considered in which emails are given sequentially and learns them one by one. As we mentioned, the purpose of this thesis is detecting spam emails.... 

Obtaining the mechanical properties of body tissues in a non-destructive manner is clinically important and has wide applications in the diagnosis and prevention of diseases. one of non-destructive methods is elastography, which requires proper modeling of the tissue and then analysis of the wave propagation in it and obtaining the propagation relations and the dispersion curves. Study of the literature revealed that many simplifications have been used in most modelings of arteries and so far the anisotropy of the artery and its layers with the effects of surrounding tissues and blood have not been studied Therefore, the aim of this study is to model the artery as a two-layer orthotropic... 

Nowadays, one of the most important desires of the human being is to reduce his living environmental pollution. Using the diluted combustion systems in new gas turbines in order to produce the minimum amount of has been done to satisfy this desire. It should be noted that reducing this amount and using the lower flame temperature will result in some consequences. The most important problem occurred in industrial and aerial gas turbines are the instability of the combustion due to dilution of the fuel to air mixture which it results in heat release fluctuations. If the heat release fluctuations and acoustic pressure are in the same phases, the amplitude of the fluctuations will increase which... 

In recent years, there have been many studies aimed at finding program defect using information of previous ones. These studies, by using the program text, previous bugs, and information related to version control and project management systems create an defect prediction model to find other defect prone areas in the program. The output of defect prediction methods is part of the program’s text, which is likely to have defects. Considering that the result of this method is just the text of the program and does not provide any extra information for finding defects to the user, these methods have not yet been applied to the software industry. On the other hand, by spreading the use of Q & A... 

The main goal of this thesis is the design and development of a rehabilitation device for helping patients “to improve blood circulation” & retain and recover their abilities if possible that were lost during the stroke or a accident like that (my research in karaj/iran shows that it is possible by just movement of the specific body part). The focus is on hand in this thesis because Injuries to the hand are common and can be very debilitating since our hands are our primary means for interacting with our world. For rehabilitation in case of human hand there are several practices that should be done for patients either in home or in a rehabilitation center, time and money that is supposed to... 

In the past few decades, shaking tables are widely used to evaluate system response of structures under seismic excitations. These devices are used without any fundamental research performed on a shaking table system as an entity model. In most of these studies for simplicity, it is assumed that there exist no considerable vibration and displacement around the shaking tables, and no attention is paid to the peripheral substances such as soil settled under the foundation.
In this thesis, result of ambient vibration test on shaking table system (solid deck, concrete foundation and soil layer) has been presented. Precise sensors known as low frequency and high accuracy accelerometers have...