Sharif Digital Repository

A method is developed for in situ generation of 1,3-dioxan-5-one derivatives 2. These compounds are simple precursors for accessing carbohydrate structures and previously had to be produced via stepwise procedures using excessive amounts of reagents. In the present work, three different derivatives of 2 were synthesized via the reaction of trialkoxyalkanes with dihydroxyacetone dimer 1 in the presence of acetic acid as the catalyst. In the same pot, derivatives of 2 were reacted with aromatic aldehydes and 30 mol% of pyrrolidine to obtain high yields of the respective bischalcones 3 within short time periods. © 2019 M. Javad Poursharifi et al., published by De Gruyter 2019  

With the advent of semantic technology, access control cannot be done in a safe way unless the access decision takes into account the semantic relationships among the entities in a semantic-aware environment. SBAC model considers this issue in its decision making process. However, time plays a crucial role in new computing environments which is not supported in the model. In this paper we introduce the Temporal Semantic Based Access Control model (TSBAC), as an extension of SBAC, which enhances the specification of user-defined authorization rules by constraining time interval and temporal expression over users' history of accesses. A formal semantics for temporal authorizations is provided... 

With the advent of semantic technology, access control cannot be done in a safe way unless the access decision takes into account the semantic relationships between entities in a semantic-aware environment. SBAC model considers this issue in the decision making process. However, time plays a crucial role in new computing environments which is not supported in this model. In this paper we introduce temporal semantic based access control model (TSBAC), as an extension of SBAC model, which enhances the specification of user-defined authorization rules by constraining time interval and temporal expression over users' history of accesses. A formal semantics for temporal authorizations is provided... 

Time plays a crucial role in access control for new computing environments, which is not supported in traditional access control models. In this paper, we propose a Generalized Temporal History Based Access Control (GTHBAC) model, aimed at integrating history-based constraints along with a generic access control model. GTHBAC enhances the specification of user-defined authorization rules by constraining time interval and temporal expression over users' history of accesses. Due to different application needs, GTHBAC uses two different time schemes, i.e., real time and logical time, in its authorization rules. A formal semantics for temporal authorizations is provided, and conflicting... 

With the advent of semantic technology' access control cannot be done in a safe way unless the access decision takes into account the semantic relationships among the entities in a semantic-aware environment. The SBAC model (Semantic Based Access Control model) considers this issue in its decision making process. However' time plays a crucial role in new computing environments'which is not supported in SBAC. In this paper' we propose the Temporal Semantic Based Access Control (TSBAC) model' as an extension of SBAC' which enhances the specification of user-defined authorization rules by constraining time interval and temporal expression over users' history of accesses. TSBAC uses logical... 

Introduction: One of the biggest impacts that the nanotechnology has made on medicine and biology, has been in the area of drug delivery systems (DDSs). Many drugs suffer from serious problems concerning insolubility, instability in biological environments, poor uptake into cells and tissues, sub-optimal selectivity for targets and unwanted side effects. Nanocarriers can be designed as DDSs to overcome many of these drawbacks. One of the most versatile building blocks to prepare these nanocarriers is the ubiquitous, readily available and inexpensive protein, serum albumin. Areas covered: This review covers the use of different types of albumin (human, bovine, rat, and chicken egg) to prepare... 

Nanotechnology has begun to play a remarkable role in various fields of science and technology. In biomedical applications, nanoparticles have opened new horizons, especially for biosensing, targeted delivery of therapeutics, and so forth. Among drug delivery systems (DDSs), smart nanocarriers that respond to specific stimuli in their environment represent a growing field. Nanoplatforms that can be activated by an external application of light can be used for a wide variety of photoactivated therapies, especially light-triggered DDSs, relying on photoisomerization, photo-cross-linking/un-cross-linking, photoreduction, and so forth. In addition, light activation has potential in photodynamic... 

There are limitations in current medications of articular cartilage injuries. Although injectable bioactive hydrogels are promising options, they have decreased biomechanical performance. Researchers should consider many factors when providing solutions to overcome these challenges. In this study, we created an injectable composite hydrogel from chitosan and human acellular cartilage extracellular matrix (ECM) particles. In order to enhance its mechanical properties, we reinforced this hydrogel with microporous microspheres composed of the same materials as the structural building blocks of the scaffold. Articular cartilage from human donors was decellularized by a combination of physical,...