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Substantial terms have been recognized on the associated risk elements, comorbidities as well as, putative pathophysiological processes of Alzheimer disease and related dementias (ADRDs) as well as, type 2 diabetes mellitus (T2DM), a few from greatest important disease from the moments. Very much is considered regarding the biology and chemistry of each predicament, nevertheless T2DM and ADRDs are an actually similar pattern developing from the similar origins of maturing or synergistic conditions connected by aggressive patho-corporeal terms and continues to be ambiguous. In this depth-critique article, we aimed to investigate all possibilities and represented a novel and applicable... 

Substantial terms have been recognized on the associated risk elements, comorbidities as well as, putative pathophysiological processes of Alzheimer disease and related dementias (ADRDs) as well as, type 2 diabetes mellitus (T2DM), a few from greatest important disease from the moments. Very much is considered regarding the biology and chemistry of each predicament, nevertheless T2DM and ADRDs are an actually similar pattern developing from the similar origins of maturing or synergistic conditions connected by aggressive patho-corporeal terms and continues to be ambiguous. In this depth-critique article, we aimed to investigate all possibilities and represented a novel and applicable... 

Natural and biodegradable polymers are of particular interest as green sources with low-cost and environmentally friendly features, and have been widely used for polymer composite development. The term “Green Composites” refers to polymer/filler systems in which polymer, filler, or sometimes both components are green in view of sources from which they are yielded or their biodegradability. Natural fibers obtained from plants, animals, and/or geological processes are a big class of green sources widely applied in green composite development. There has also been continued research on recycling of green composite as well as developing hybrid systems for advanced applications. In view of their... 

Natural and biodegradable polymers are of particular interest as green sources with low-cost and environmentally friendly features, and have been widely used for polymer composite development. The term “Green Composites” refers to polymer/filler systems in which polymer, filler, or sometimes both components are green in view of sources from which they are yielded or their biodegradability. Natural fibers obtained from plants, animals, and/or geological processes are a big class of green sources widely applied in green composite development. There has also been continued research on recycling of green composite as well as developing hybrid systems for advanced applications. In view of their... 

In this work, a green synthesis method was designed and practiced to develop bioactive and biocompatible carbon-based nanocomposites biomaterials. ZnO nanoparticles were synthesized in assistance of leaf extracts and added to a composite nanostructure composed of the reduced graphene oxide (rGO) and multi-walled carbon nanotubes (MWCNT). The resulting green nanocomposite revealed ability to make π-π interactions, hydrogen bonding, and van der Waals interactions with the doxorubicin (DOX). Then, the surface morphology of the synthesized nanocomposite was investigated, and the interrelationship between the surface morphology, relative cell viability, and drug uptake and release behavior were... 

In this work, a green synthesis method was designed and practiced to develop bioactive and biocompatible carbon-based nanocomposites biomaterials. ZnO nanoparticles were synthesized in assistance of leaf extracts and added to a composite nanostructure composed of the reduced graphene oxide (rGO) and multi-walled carbon nanotubes (MWCNT). The resulting green nanocomposite revealed ability to make π-π interactions, hydrogen bonding, and van der Waals interactions with the doxorubicin (DOX). Then, the surface morphology of the synthesized nanocomposite was investigated, and the interrelationship between the surface morphology, relative cell viability, and drug uptake and release behavior were... 

Nanoparticles and nanomaterials in cancer therapy as well as in all biomedical applications have been heavily investigated over the last decade. In this manner, green synthesized nanomaterials have been vastly considered as promising, cost effective, and environmentally friendly components. Also, green synthesis methods could reduce cytotoxicity as well as increase the biocompatibility of the final products. In this chapter, the role of nanomaterials obtained from biowaste specifically for cancer therapy is discussed. © 2023 Elsevier Ltd. All rights reserved  

Silk fibroin (SF) has been broadly applied in wound dressing fabrication because of its proper features for wound healing. In this work, we developed a carboxymethyl cellulose (CMC)/gelatin blend film with different concentrations of glycerol, and modified the optimized film with an SF layer through electrospinning process. Tensile strength and cell viability evaluation of blend films demonstrated that the glycerol content of 3% could be suitable as the substrate layer for the two-layer wound dressing. The morphology of the blend film and electrospun nanofibers was obtained from scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR). It concluded that... 

This paper proposes a new coordinated voltage control scheme to ensure voltage security of power systems. The scheme schedules reactive power injection from VAR sources, including synchronous generators and condensers, capacitor banks, switchable reactors and FACTS devices, to ensure desired loading margin of power systems for a given horizon of time. The problem is treated as voltage security constrained multi-period optimal reactive power flow (VSC-MPORPF). To incorporate scheduling of both continuous and discrete VAR sources, the VSC-MPORPF is formulated as a mixed-integer nonlinear programming problem, and is solved using generalized Benders decomposition (GBD). Multi-period formulation... 

Voltage stability is the ability of a power system to maintain acceptable voltages at all buses in the system under normal conditions and after being subjected to a disturbance. This paper employs the management of reactive power generation to improve the voltage stability margin (VSM), in the framework of optimal reactive power dispatch (ORD) problem. Scheduling of VAR sources is performed using the concept of relative value of VAR sources. The proposed methodology has been tested on the IEEE 14-bus test system. Simulation results show that after the optimal reactive power scheduling, VSM of the systems is increased considerably. In addition, it is observed that reactive power reserve is... 

Management of reactive power resources is vital for stable and secure operation of power systems in the view point of voltage stability. This paper deals with the management of on-load tap changers (OLTCs) and dynamic VAR sources (including synchronous generators, synchronous condensers, and shunt reactive power compensators) to improve voltage stability margin (VSM) of power systems. This problem is usually called optimal reactive power dispatch (ORD) in the literature. The main contribution of the paper is to introduce a new objective function for the ORD problem. The proposed objective function is derived based on a local voltage stability index, called DSY, and has a strong correlation... 

Advancements in material science and engineering, especially in the field of porous nanomaterials lead to new types of therapeutics and technologies. Among different types of porous nanomaterials, metal–organic frameworks (MOFs) have been considered the most promising inorganic nanomaterials due to their significant stability and ease of functionalization. To date, very limited research has been done on developing nanocomposites based on MOFs and MXenes. The current experiment has been performed to design a novel UiO-66 MOF and MXene nanocomposite, modified with Rosmarinus officinalis (RO) leaf extracts for co-delivery of doxorubicin (DOX)/clustered regularly interspaced short palindromic... 

This review covers the development of bioresorbable polymeric composites for applications in tissue engineering. Various commercially available bioresobable polymers are described, with emphasis on recent bioresorbable composites based on natural and synthetic polymers. Bioresorbable polymers contain hydrolyzable bonds, which are subjected to chemical degradation via either reactive hydrolysis or enzyme-catalyzed active hydrolysis. For synthetic polymers, chemical hydrolysis is the most important mode of degradation. The degradation rate can be controlled by varying the molecular weight and crystallinity. Examples of bioresorbable polymers are: polyurethane, poly(D,L)lactide,... 

This review covers the development of bioresorbable polymeric composites for applications in tissue engineering. Various commercially available bioresobable polymers are described, with emphasis on recent bioresorbable composites based on natural and synthetic polymers. Bioresorbable polymers contain hydrolyzable bonds, which are subjected to chemical degradation via either reactive hydrolysis or enzyme-catalyzed active hydrolysis. For synthetic polymers, chemical hydrolysis is the most important mode of degradation. The degradation rate can be controlled by varying the molecular weight and crystallinity. Examples of bioresorbable polymers are: polyurethane, poly(D,L)lactide,... 

With the passage of time and more advanced societies, there is a greater emergence and incidence of disease and necessity for improved treatments. In this respect, nowadays, aptamers, with their better efficiency at diagnosing and treating diseases than antibodies, are at the center of attention. Here, in this review, we first investigate aptamer function in various fields (such as the detection and remedy of pathogens, modification of nanoparticles, antibiotic delivery and gene delivery). Then, we present aptamer-conjugated nanocomplexes as the main and efficient factor in gene delivery. Finally, we focus on the targeted co-delivery of genes and drugs by nanocomplexes, as a new exciting... 

Carbosilane dendrimers are a particular type of dendrimer structure that has been used as delivery vehicles for drugs and nucleic acids. They have a defined structure according to their generation number, and their terminal groups can be rendered cationic or anionic. The cationic charges can address the limitation of electrostatic repulsion between the negatively charged phosphate groups of nucleic acids and negatively charged cell membranes. Specific drugs can be loaded into the central part of the dendrimer or attached at the exterior, and the overall positive charge may improve the efficacy of anti-inflammatory drugs. One promising feature of dendrimers is their non-toxicity both in vitro... 

The present work was aimed to account a green and eco-friendly synthesis of palladium nanoparticles using Rosmarinus officinalis leaves extracts for the first time, therefore, that can be an acceptable replacement for chemical media to improve potential biological properties. The synthesized palladium nanoparticles were fully characterized using FT-IR, XRD, FESEM, TEM and UV/Vis spectroscopy techniques. Catalytic activity was investigated by Mizoroki-Heck reaction, and optimized based on solvent, temperature and time of the reaction, and the best results were found in water as a green media without any additional reagents. Biological activity of the synthesized nanoparticles were evaluated... 

Solar heating and cooling technologies can have a vital role to play in understanding the targets in energy security, economic development, and mitigating climate change. This study aimed to investigate the performance of the combined solar cooling/heating system using a Photovoltaic Thermal collector (PVT) for residential applications. The main advantage of using PVT is the conversion of the maximum amount of solar energy into electricity and thermal energy. In this work, water is used to cool the panel and, consequently, increase the efficiency. The cooling cycle comprises a hybrid ejector-compression refrigeration cycle with two evaporator temperatures. To reduce the effect of the global... 

Searching large image databases is a time consuming process when done manually. Current CBIR methods mostly rely on training data in specific domains. When source and domain of images are unknown, unsupervised methods provide better solutions. In this work, we use a hierarchical clustering scheme to group images in an unknown and large image database. In addition, the user should provide the current class assignment of a small number of images as a feedback to the system. The proposed method uses this feedback to guess the number of required clusters, and optimizes the weight vector in an iterative manner. In each step, after modification of the weight vector, the images are reclustered. We... 

Humanity's challenges are becoming increasingly difficult, and as these challenges become more advanced, the need for effective and intelligent action becomes more apparent. Meanwhile, the novel coronavirus disease (COVID-19) pandemic, which has plagued the world, could be considered as an opportunity to take a step toward the need for atomic engineering, compared to molecular engineering, as well as to accelerate this type of research. This approach, which can be expressed in terms of picotechnology, makes it possible to identify living cell types or in general, chemical and biological surfaces using their atomic arrays, and applied for early diagnosis even treatment of the disease. © 2020...