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Synthesis of Dithiocarbamate Salts, Reaction of Divinyl Sulfone with Amines and CS2 & Polymerization of Diamines and CS2 with Michael Acceptors
, M.Sc. Thesis Sharif University of Technology ; Mahmoodi Hashemi, Mohammad (Supervisor) ; Ziyaei Halimjani, Azim (Supervisor)
Abstract
At the first part of project, different kinds of monodithiocarbamates were synthesized.In order to prepare these compounds two methods have been used:Reactions of amines and carbon disulfide in water and finally addition of Michael acceptors.Reaction of amines and carbon disulfide, then addition of alkyl halides under solvent-free conditions.Dithiocarbamate salts are prepared in ether by using CF3SO3CH3 as the methylation agent with resulted monodithiocarbamates at the first part of the project. These salts are found to be ionic liquids, which is important class of organic compounds.At the second part of project, the Michael additions of amines with divinyl sulfone are investigated in...
Evaluation and Analysis of tDCS and tACS in Improvement of Tinnitus Condition
, M.Sc. Thesis Sharif University of Technology ; Jahed, Mehran (Supervisor) ; Hani Tabatabaie, Mozhgan (Co-Supervisor) ; Asadpour, Abdureza (Co-Supervisor)
Abstract
Tinnitus is variety of sounds heard when no corresponding external sound is present. To remedy this condition, various methods have been proposed, however none have resulted in systematic and lasting results. This study aims to investigate the efficacy of non-invasive electrical stimulation techniques (tES) in the treatment of tinnitus. Stimulation parameters, including intensity, frequency, duration, and session frequency, are tailored to the individual's subjective tinnitus characteristics and treatment goals. Specifically, transcranial direct current stimulation (tDCS) is explored as a non-invasive method of electrical stimulation. In the tDCS method, electrodes are strategically...
Analysis of rTMS in Improvement of Tinnitus using EEG and fMRI
, M.Sc. Thesis Sharif University of Technology ; Jahed, Mehran (Supervisor) ; Asadpour, Abdureza (Co-Supervisor) ; Hani Tabatabaei, Mozhgan (Co-Supervisor) ; Mehrkian, Saiedeh (Co-Supervisor)
Abstract
Tinnitus means hearing a sound without an external source. Despite the research done in relation to it, it is still an unknown phenomenon and no method has been introduced to treat it. Repetitive transcranial magnetic stimulation is one of the methods that its effectiveness in decreasing tinnitus sound is still under investigation. This technology is a non-invasive method to stimulate the brain, which modulates the activity of neurons by applying successive electromagnetic pulses on the scalp. Most of the studies conducted in this field have used clinical evaluations to investigate the effect of stimulation. Relying on this method alone to evaluate the effect of stimulation cannot take a...
STAT3 as a newly emerging target in colorectal cancer therapy: tumorigenesis, therapy response, and pharmacological/nanoplatform strategies
, Article Environmental Research ; Volume 233 , 2023 ; 00139351 (ISSN) ; Abbaszadeh, S ; Rashidi, M ; Amini, N ; Talebi Anaraki, K ; Motahhary, M ; Khalilipouya, E ; Harif Nashtifani, A ; Shafiei, S ; Ramezani Farani, M ; Nabavi, N ; Salimimoghadam, S ; Aref, A. R ; Raesi, R ; Taheriazam, A ; Entezari, M ; Zha, W ; Sharif University of Technology
Academic Press Inc
2023
Abstract
Colorectal cancer (CRC) ranks as the third most aggressive tumor globally, and it can be categorized into two forms: colitis-mediated CRC and sporadic CRC. The therapeutic approaches for CRC encompass surgical intervention, chemotherapy, and radiotherapy. However, even with the implementation of these techniques, the 5-year survival rate for metastatic CRC remains at a mere 12–14%. In the realm of CRC treatment, gene therapy has emerged as a novel therapeutic approach. Among the crucial molecular pathways that govern tumorigenesis, STAT3 plays a significant role. This pathway is subject to regulation by cytokines and growth factors. Once translocated into the nucleus, STAT3 influences the...