Sharif Digital Repository

Magnesium oxide nanoparticles (MgO NPs) have emerged as potential materials for various biomedical applications due to their unique physicochemical properties, including biodegradability, biocompatibility, cationic capacity, high stability and redox properties. MgO NPs have become an attractive platform to combat microbes and may be a promising alternative to overcome challenges associated with eliminating microbial biofilms and antibiotic resistance. Hence, due to the increasing use of MgO NPs in biomedicine, new synthetic strategies for MgO NPs are necessary. MgO NPs synthesised using green methods are non-toxic, eco-friendly and have high stability for a wide range of biological, medical... 

Bimodal magnetic-fluorescent materials for diagnostic imaging needs surface-engineered nanoparticles with great biosafety, pronounced colloidal stability, high magnetic moments, and strong photoluminescence (PL) emission. This work presents polymer-coated nanoparticles (PCNPs) based on manganese ferrites covered with a thin shell of nitrogen-doped carbon dots for magnetic-resonance and fluorescent dual mode imaging of cancerous tumors in vivo. An in situ thermolysis of metal oxalates and phenylenediamine in diphenyl ether allows for the facile synthesis of hybrid magneto-fluorescent nanoparticles. They possess an average size of 55 ± 5 nm with strong and excitation-independent PL emission at... 

In recent years, key questions about the interaction of 2D MXene nanomaterials in electrochemical and biomedical applications have been raised. Most research has focused on clarifying the exclusive properties of the materials; however, only limited reports have described the biomedical applications of 2D nanomaterials. 2D MXenes are monolayer atomic nanosheets resulting from MAX phase ceramics. The hydrophilic properties, metallic conductivity, stability, and exclusive physiochemical performances make them promising materials for electrochemical and biomedical applications, including CO2 reduction, H2 evolution, energy conversion and storage, supercapacitors, stimuli-responsive drug delivery... 

Cancer is a deadly disease that has long plagued humans and has become more prevalent in recent years. The common treatment modalities for this disease have always faced many problems and complications, and this has led to the discovery of strategies for cancer diagnosis and treatment. The use of magnetic nanoparticles in the past two decades has had a significant impact on this. One of the objectives of the present study is to introduce the special properties of these nanoparticles and how they are structured to load and transport drugs to tumors. In this study, iron oxide (Fe3O4) nanoparticles with 6 nm sizes were coated with hyperbranched polyglycerol (HPG) and folic acid (FA). The... 

Dopamine is one of the most important neurotransmitters released by neurons in the central nervous system, and a variety of neurological illnesses and mental disorders are associated with impairments in the secretion and functionality of dopamine. Dopamine, depending on the type of receptors, can act as a stimulant or an inhibitor. In this study, dendrimer-conjugated dopamine was utilized as a chelating agent for Technetium-99m to investigate the organ distribution of this compound in vivo using the single-photon emission computed tomography (SPECT) technique. For this purpose, dendrimers were synthesized using polyethylene glycol diacid and citric acid precursors, and dopamine was... 

Organ-on-a-chip (OOC) systems are engineered nanobiosystems to mimic the physiochemical environment of a specific organ in the body. Among various components of OOC systems, biomimetic membranes have been regarded as one of the most important key components to develop controllable biomimetic bioanalysis systems. Here, we review the preparation and characterization of biomimetic membranes in comparison with the features of the extracellular matrix. After that, we review and discuss the latest applications of engineered biomimetic membranes to fabricate various organs on a chip, such as liver, kidney, intestine, lung, skin, heart, vasculature and blood vessels, brain, and multiorgans with... 

In this paper, the large amplitude free vibration of a cantilever Timoshenko beam is considered. To this end, first Hamilton's principle is used in deriving the partial differential equation of the beam response under the mentioned conditions. Then, implementing the Galerkin's method the partial differential equation is converted to an ordinary nonlinear differential equation. Finally, the method of multiple scales is used to determine a second order perturbation solution for the obtained ODE. The results show that nonlinearity acts in the direction of increasing the natural frequency of the thick-cantilevered beam  

In this study, novel graphene oxide/chitosan nanocomposite coatings with long term drugeluting potential are presented. The coatings are fabricated by the facile and reproducible electrophoretic deposition technique. Analysis of the prepared films shows that the graphene oxide nanosheets are exfoliated in the chitosan matrix. Fourier-transform infrared spectrometry reveals polymer attachment to the carboxylic bonds of graphene oxide, providing a strong interaction and exfoliation of the nanolayers. In vitro viability assay by human osteosarcoma cells (MG-63) demonstrates that the nanocomposite films are highly biocompatible up to 30 wt% graphene oxide, but at higher concentrations a slight... 

The prediction of rock sawability is very important in the cost estimation and the best planning of the plants. Rock sawability depends on the machine characteristics and rock mechanical properties. In this study, a new classification was developed with the respect to rock mechanical properties such as Uniaxial Compressive Strength, Brazilian tensile strength, Schmidt hammer value and Los Angeles abrasion loss. Using this system the carbonate rock sawability index (CRSi) of several types of carbonate rock was evaluated and classifi ed into fi ve categories and then a new model was developed with the respect to CRSi and machining characteristics by using the statistical analyses for... 

Considering the remarkable characteristics of nanomaterials, previous research studies investigated the effects of incorporating different types of these materials on improving the concrete properties. However, further studies are required to evaluate the complementary hybridization and synergistic influence of nanomaterials. In this research, the combined effect of adding nano silica particles (NS) and multi-walled carbon nanotubes (MWCNT) on enhancing both the compressive and flexural strengths of the cement paste was investigated. Moreover, the morphology of the interface between cement paste and aggregates was studied by scanning electron microscopy (SEM). The mixtures were prepared... 

Wireless Sensor Networks (WSNs) have been weaved into the fabric of our daily lives. The foremost impediment in the rapid development of these networks is the energy limitation which inhibits them from meeting specific application requirements. Recently, the advances in energy harvesting technology have made it possible to replenish the energy of sensors via external sources. Energy Harvesting-Wireless Sensor Networks (EH-WSNs) are being transformed from a visionary concept into reality. However, this concept is still in its infancy and calls for extensive research to cater to the needs of WSNs. For future progress of EH-WSNs, Medium Access Control (MAC) layer has undoubtedly a decisive role... 

In this paper, a new approach is presented for optimal control of large-scale chemical processes. In this approach, the chemical process is decomposed into smaller sub-systems at the first level, and a coordinator at the second level, for which a two-level hierarchical control strategy is designed. For this purpose, each sub-system in the first level can be solved separately, by using any conventional optimization algorithm. In the second level, the solutions obtained from the first level are coordinated using a new gradient-type strategy, which is updated by the error of the coordination vector. The proposed algorithm is used to solve the optimal control problem of a complex nonlinear... 

In this paper, vibration analysis of rotating laminated composite cylindrical shells using a combination of the layerwise theory and wave propagation approach is investigated. This combination enables us to study all the conventional boundary conditions in our analysis. Results obtained have been compared with those available in the literature and a good agreement has been observed. In contrast to the Equivalent Single Layer theories (ESL), the layerwise theory is constructed on the basis ofC°- continuity through the laminate thickness. For the surface of the shell, a displacement field based on the wave propagation approach is proposed. The effect of Coriolis and centrifugal accelerations... 

This paper presents a two-level optimal control for the binary distillation column. From the control point of view, the binary distillation column is a high-order system consisting of several interconnected subsystems (trays) that aim to maximize output purity. Controlling the system in a hierarchical manner not only decreases complexity and solution time but also can improve the control structure's reliability. In this study, the distillation column is decomposed into NT second-order subsystems, each representing one stage (one tray). Accordingly, the cost function is decomposed, and thus, the overall problem is converted into NT lower-order subproblems where each tray has its own... 

The safety and optimal performance of nuclear reactors require online monitoring in the core. The present paper describes a method that avoids the solution of the time-dependent neutron diffusion equation, and it uses online readings of the fixed in-core neutron detectors to reconstruct the three-dimensional (3D) neutron flux distribution. The essential idea of the nodal synthesis method is the separation of time and space-dependence of the neutron flux distribution. The time-dependent section of the flux distribution is determined by in-core neutron detector readings, and the space-dependent section is obtained from pre-computed harmonics of the neutron diffusion equation. In online... 

The safety and optimal performance of nuclear reactors require online monitoring in the core. The present paper describes a method that avoids the solution of the time-dependent neutron diffusion equation, and it uses online readings of the fixed in-core neutron detectors to reconstruct the three-dimensional (3D) neutron flux distribution. The essential idea of the nodal synthesis method is the separation of time and space-dependence of the neutron flux distribution. The time-dependent section of the flux distribution is determined by in-core neutron detector readings, and the space-dependent section is obtained from pre-computed harmonics of the neutron diffusion equation. In online... 

Colorectal cancer (CRC) ranks as the third most aggressive tumor globally, and it can be categorized into two forms: colitis-mediated CRC and sporadic CRC. The therapeutic approaches for CRC encompass surgical intervention, chemotherapy, and radiotherapy. However, even with the implementation of these techniques, the 5-year survival rate for metastatic CRC remains at a mere 12–14%. In the realm of CRC treatment, gene therapy has emerged as a novel therapeutic approach. Among the crucial molecular pathways that govern tumorigenesis, STAT3 plays a significant role. This pathway is subject to regulation by cytokines and growth factors. Once translocated into the nucleus, STAT3 influences the...