Sharif Digital Repository

Objective(s): Seizure detection during online recording of electrophysiological parameters is very important in epileptic patients. In the present study, online analysis of field potential recordings was used for detecting spontaneous seizures in epileptic animals. Materials and Methods: Epilepsy was induced in rats by pilocarpine injection. During the chronic period of the pilocarpine model, local field potential (LFP) recording was run for at least 24 hr. At the same time, video monitoring of the animals was done to determine the real time of seizure occurrence. Both power and sample entropy of LFP were used for online analysis. Results: Obtained results showed that changes in LFP power... 

Cognitive functions such as working memory require integrated activity among different brain regions. Notably, entorhinal cortex (EC) activity is associated with the successful working memory task. Olfactory bulb (OB) oscillations are known as rhythms that modulate rhythmic activity in widespread brain regions during cognitive tasks. Since the OB is structurally connected to the EC, we hypothesized that OB could modulate EC activity during working memory performance. Herein, we explored OB–EC functional connectivity during spatial working memory performance by simultaneous recording local field potentials when rats performed a Y-maze task. Our results showed that the coherence of delta,... 

Normal human breathing exhibits complex variability in both respiratory rhythm and volume. Analyzing such nonlinear fluctuations may provide clinically relevant information in patients with complex illnesses such as asthma. We compared the cycle-by-cycle fluctuations of inter-breath interval (IBI) and lung volume (LV) among healthy volunteers and patients with various types of asthma. Continuous respiratory datasets were collected from forty agematched men including 10 healthy volunteers, 10 patients with controlled atopic asthma, 10 patients with uncontrolled atopic asthma, and 10 patients with uncontrolled non-atopic asthma during 60 min spontaneous breathing. Complexity of breathing... 

Mechanical ventilation (MV) can result in long-term brain impairments that are resistant to treatment. The mechanisms underlying MV-induced brain function impairment remain unclear. Since nasal airflow modulates brain activity, here we evaluated whether reinstating airflow during MV could influence the memory performance of rats after recovery. Rats were allocated into two study groups: one group received rhythmic air-puff into the nasal cavity during MV and a control group that underwent ventilation without air-puff. During MV, air-puffs induced time-locked event potentials in OB, mPFC and vHPC and significantly increased the oscillatory activity at the air-puff frequency. Furthermore, in... 

Allergic rhinitis (AR) is a chronic inflammatory disease frequently associated with a deficit in learning and memory. Working memory is an important system for decision making and guidance, which depends on interactions between the ventral hippocampus (vHipp) and the prelimbic prefrontal cortex (plPFC). It is still unclear whether AR influences the activity and coupling of these brain areas, which consequently may impair working memory. The current study aimed to examine alterations of the vHipp-plPFC circuit in a rat model of AR. Our results show decreased working memory performance in AR animals, accompanied by a reduction of theta and gamma oscillations in plPFC. Also, AR reduces... 

Anxiety is prevalent in asthma, and is associated with disease severity and poor quality of life. However, no study to date provides direct experimental evidence for the effect of allergic inflammation on the structure and function of medial prefrontal cortex (mPFC) and amygdala, which are essential regions for modulating anxiety and its behavioral expression. We assessed the impact of ovalbumin (OVA)-induced allergic inflammation on the appearance of anxiety-like behavior, mPFC and amygdala volumes using MRI, and the mPFC-amygdala circuit activity in sensitized rats. Our findings exhibited that the OVA challenge in sensitized rats induced anxiety-like behavior, and led to more activated... 

Asthma is a chronic inflammatory disease associated with a high prevalence of psychiatric disorders. There are specific brain networks responsible for emotional processes, including two important networks associated with psychiatric problems: the default mode network (DMN), which is more active in the resting state, and the salience network (SN), which is structurally connected to DMN. Although previous studies suggested that neuro-phenotypes of asthma may be recognizable by the neural activity of brain circuits, an association between the brain's functional alterations and psychiatric impairments induced by asthma remains unknown. We aimed to assess DMN and SN activity and its association... 

Several methods have been developed in the past for analyzing the porosity and other types of well logs for large-scale porous media, such as oil reservoirs, as well as their permeability distributions. We developed a method for analyzing the porosity logs φ(h) (where h is the depth) and similar data that are often nonstationary stochastic series. In this method one first generates a new stationary series based on the original data, and then analyzes the resulting series. It is shown that the series based on the successive increments of the log y(h)=φ(h+δh)-φ(h) is a stationary and Markov process, characterized by a Markov length scale hM. The coefficients of the Kramers-Moyal expansion for... 

Yeh et al. have recently proposed a mutual authentication protocol based on EPC Class-1 Gen.-2 standard. They claim their protocol is secure against adversarial attacks and also provides forward secrecy. In this paper we show that the proposed protocol does not have cited security features properly. A powerful and practical attack is presented on this protocol whereby the whole security of the protocol is broken. Furthermore, Yeh et al.'s protocol does not assure the untraceabilitiy and backwarduntraceabilitiy attributes. We also will propose our revision to safeguard the Yeh et al.'s protocol against cited attacks  

In this paper, we show how time-sharing method may reduce transmission delay in the dynamic index coding scenario. We propose a novel time-shared dynamic index coding transmission scheme that achieves the maximum index coding gain for a complete bi-directional side information graph and formulate a constrained optimization problem to tune the transmission scheme for the minimum transmission delay. A closed-form solution is presented for the special case of two-user. We also use analytical and simulation results to provide graphical intuition for the obtained results  

This paper suggests methods for improving efficiency of a high step up high efficiency converter based on three state commutation cells. A loss analysis has been performed to identify the source of power loss. Based on this analysis, methods are presented to reduce losses in the most power dissipating elements. These methods include replacing some power diodes with large conduction losses with MOSFETs having small on-state resistance. Efficiency improvement up to %1.25 percent is verified in simulation and experimental results  

Locally multipath adaptive routing (LMAR) protocol, classified as a new reactive distance vector routing protocol for MANETs is proposed in this paper. LMAR can find an ad-hoc path without selfish nodes and wormholes using a random search algorithm in polynomial-time. Also when the primary path fails, it discovers an alternative safe path if network graph remains connected after eliminating selfish/malicious nodes. The main feature of LMAR to seek safe route free of selfish and malicious nodes in polynomial time is its searching algorithm and flooding stage that its generated traffic is equiloaded compared to single-path routing protocols but its ability to bypass the attacks is much better... 

von Willebrand factor (VWF) is a naturally collapsed protein that participates in primary haemostasis and coagulation events. The clotting process is triggered by the adsorption and conformational changes of the plasma VWFs localized to the collagen fibres found near the site of injury. We develop coarse-grained models to simulate the adsorption dynamics of VWF flowing near the adhesive collagen fibres at different shear rates and investigate the effect of factors such as interaction and cooperativity of VWFs on the success of adsorption events. The adsorption probability of a flowing VWF confined to the receptor field is enhanced when it encounters an adhered VWF in proximity to the... 

A general regression neural network technique was applied to design optimization of a liquid-liquid coaxial swirl injector. Phase Doppler Anemometry measurements were used to train the neural network. A general regression neural network was employed to predict droplet velocity and Sauter mean diameter at any axial or radial position for the operating range of a liquid-liquid coaxial swirl injector. The results predicted by neural network agreed satisfactorily with the experimental data. A general performance map of the liquid-liquid coaxial swirl (LLCS) injector was generated by converting the predicted result to actual fuel/oxidizer ratios. © 2008 WILEY-VCH Verlag GmbH & Co. KGaA  

Development of Smart Grid and deployment of smart meters in large scale has raised a lot of concerns regarding customers’ privacy. Consequently, several schemes have been proposed to overcome the above mentioned issue. These schemes mainly rely on data aggregation as a method of protecting users’ privacy from the grid operators. However, the main problem with most of these schemes is the fact that they require a large amount of processing power at the meter side. This, together with the fact that smart meters don't usually have a powerful processor, can cause the unavailability of smart meter data at the required time for operators of the grid, and at the same time prevents smart meters from... 

Real-time applications play a significant role in the area of VANET, and are mainly required for these kinds of networks. On the other hand, when the number of messages received by vehicles increases in the network, then the applied computation load becomes extremely high and consequently, delay on the message authentication process significantly increases. This paper is presented with the aim of introducing a novel cooperative message authentication (CMA) scheme for VANET, the main purpose of which is alleviating the computation load on vehicles while verifying messages by using two-part identity-based signature. The scheme enables vehicles to verify only a limited number of the total... 

A general regression neural network technique is applied for design optimization of liquid-liquid coaxial swirl injectors. Phase Doppler Anemometry measurements for velocity and SMD distributions for various Reynolds numbers are used to train the neural network to generate the injector's performance map. Excellent agreement between the predicted values and the measurements is obtained. It is observed that by reducing the number of randomly selected training samples to about one third of the number of prediction points, one may reconstruct the velocity field in the extrapolation regime with an accuracy of 93%. Copyright © 2005 by the American Institute of Aeronautics and Astronautics, Inc.... 

A general regression neural network technique is proposed for design optimization of pressure-swirl injectors. Phase doppler anemometry measurements for velocity distributions are used to train the neural network. An overall optimized value for the width of the probability is determined. The velocity field in the extrapolation regime is reconstructed with an accuracy of 93%. Excellent agreement between the predicted values and the measurements is obtained. The results indicate that the capability of performing designand optimization studies for pressure-swirl injectors with sufficient accuracy exists by applying modest amount of data in conjunction with an overall optimized value for the... 

Hybrid bioactive inorganic-organic carbon-based nanocomposites of reduced graphene oxide (rGO) nanosheets enlarged with multi-walled carbon nanotubes (MWCNTs) were decorated to provide a suitable space forin situgrowth of CoNi2S4and green-synthesized ZnO nanoparticles. The ensuing nanocarrier supplied π-π interactions between the DOX drug and a stabilizing agent derived from leaf extracts on the surface of ZnO nanoparticles and hydrogen bonds; gene delivery of (p)CRISPR was also facilitated by chitosan and alginate renewable macromolecules. Also, these polymers can inhibit the potential interactions between the inorganic parts and cellular membranes to reduce the potential cytotoxicity....