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Targeted Theranostic Delivery System Based on Liposomes Containing Graphene Quantum Dots and Drug Nanoparticles For Monitoring and Treatment of Breast Cancer
, Ph.D. Dissertation Sharif University of Technology ; Simchi, Abdolreza (Supervisor) ; Sabzevari, Omid (Supervisor)
Abstract
Theranostic liposomes have recently found a broad range of applications in nanomedicine due to stability, the high solubility of biomacromolecules, bioavailability, efficacy, and low adverse effects. However, the limitations of liposomes concerning the short systemic circulation in the body, limited controllability of the release rate, and the inability of in vivo imaging remain challenging. Herein, the development of novel hybrid ultrasound-activated piezoelectric nanoparticles based on a hybrid liposome nanocarrier composed of poly(vinylidene fluoride‐trifluoroethylene), graphene quantum dots (GQDs), and Silibinin (a hydrophobic drug) is presented. The hybrid nanoparticles are an...
Dynamics of HIV-1 Infection Models: Saturation Infection, an Eclipse Stage, CTL Immune Response
, M.Sc. Thesis Sharif University of Technology ; Hesaaraki, Mahmoud (Supervisor)
Abstract
In this thesis, three mathematical models are considered for the viral dynamics of HIV-1. The first model is an HIV infection model with saturation infection and intracellular delay, which forms a three-dimensional differential equations system, the second model includes an eclipse stage of infected cells, The viral dynamics of this model is described by four nonlinear ordinary differential equations, and finally, we study a delayed six-dimensional HIV model with CTL immune response, in fact, the main issue is the analysis of the second model (model including an eclipse stage for the infected cells).In this thesis is obtained sufficient conditions for persistence or eradication of the...
Time of concentration of surface flow in complex hillslopes
, Article Journal of Hydrology and Hydromechanics ; Volume 61, Issue 4 , 2013 , Pages 269-277 ; 0042790X (ISSN) ; Saghafian, B ; Talebi, A ; Ardakanian, R ; Sharif University of Technology
Versita
2013
Abstract
Time of concentration (TC) of surface flow in watersheds depends on the coupled response of hillslopes and stream networks. The important point in this background is to study the effects of the geometry and the shape of complex hillslopes on the time of concentration considering the degree of flow convergence (convergent, parallel or divergent) as well as the profile curvature (concave, straight or convex). In this research, the shape factor of complex hillslopes as introduced by Agnese et al. (2007) is generalized and linked to the TC. A new model for calculating TC of complex hillslopes is presented, which depends on the plan shape, the type and degree of profile curvature, the Manning...
A steady-state saturation model to determine the subsurface travel time (STT) in complex hillslopes
, Article Hydrology and Earth System Sciences ; Volume 14, Issue 6 , Jun , 2010 , Pages 891-900 ; 10275606 (ISSN) ; Talebi, A ; Ardakanian, R ; Shamsai, A ; Sharif University of Technology
2010
Abstract
The travel time of subsurface flow in complex hillslopes (hillslopes with different plan shape and profile curvature) is an important parameter in predicting the subsurface flow in catchments. This time depends on the hillslopes geometry (plan shape and profile curvature), soil properties and climate conditions. The saturation capacity of hillslopes affect the travel time of subsurface flow. The saturation capacity, and subsurface travel time of compound hillslopes depend on parameters such as soil depth, porosity, soil hydraulic conductivity, plan shape (convergent, parallel or divergent), hillslope length, profile curvature (concave, straight or convex) and recharge rate to the groundwater...
Artificial intelligence evaluation of COVID-19 restrictions and speech therapy effects on the autistic children’s behavior
, Article Scientific Reports ; Volume 13, Issue 1 , 2023 ; 20452322 (ISSN) ; Amelirad, O ; Moradi, Z ; Habibi, M ; Sharif University of Technology
Nature Research
2023
Abstract
In the present study, we aimed to quantify the effects of COVID-19 restrictions and speech treatment approaches during lockdowns on autistic children using CBCL and neuro-fuzzy artificial intelligence method. In this regard, a survey including CBCL questionnaire is prepared using online forms. In total, 87 children with diagnosed Autism spectrum disorders (ASD) participated in the survey. The influences of three treatment approaches of in-person, telehealth and public services along with no-treatment condition during lockdown were the main factors of the investigation. The main output factors were internalized and externalized problems in general and their eight subcategory syndromes. We...
Three-component coupling of boronic acids, amines, and carbon disulfide by a heterogeneous catalyst of copper (II) embedded in a highly porous and magnetic schiff base network of melamine
, Article Research on Chemical Intermediates ; Volume 49, Issue 10 , 2023 , Pages 4423-4441 ; 09226168 (ISSN) ; Kohestanian, M ; Sabzevari, A ; Pourjavadi, A ; Sharif University of Technology
Springer Science and Business Media B.V
2023
Abstract
In this work, the mesoporous magnetic heterogeneous catalyst was synthesized by anchoring copper (II) onto the nitrogen-rich poly (melamine) Schiff base networks magnetic nanocomposite. First, MNP (Fe3O4@SiO2) was functionalized with chlorosilane (CPTS). Then, the chlorine of these functionalized magnetic nanoparticles could react with the –NH2 groups of the melamine through a nucleophilic substitution reaction. Simultaneously, the condensation polymerization of melamine and benzene-1, 3, 5-tricarbaldehyde was carried out in the presence of surface-modified magnetic nanoparticles. Later, Fourier-transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), thermogravimetric analysis...
Production Study of Protease Enzyme by Immobilized Cells
,
M.Sc. Thesis
Sharif University of Technology
;
Yaghmaei, Soheila
(Supervisor)
;
Kazemi, Akhtarelmolook
(Supervisor)
Abstract
Microbial proteases are among the most important hydrolytic enzymes and havebeen studied extensively since the advent of enzymology. They are essentialconstituents of all forms of life on earth, including prokaryotes, fungi, plants andanimals.In recent years there has been a phenomenal increase in the use of alkaline protease asindustrial catalysts. Alkaline proteases (EC.3.4.21–24, 99) are defined as thoseproteases which are active in a neutral to alkaline pH range. Cell immobilization is a technique that restricts the free movements of microorganisms in the process and it has a lot of advantages including this fact that biotechnologists’ dream for using continuous system in fermentation...
Alkaline protease production by immobilized cells using B. licheniformis
, Article Scientia Iranica ; Volume 20, Issue 3 , 2013 , Pages 607-610 ; 10263098 (ISSN) ; Kazemi, A ; Nahid, P ; Yaghmaei, S ; Sabzevari, M. A ; Sharif University of Technology
2013
Abstract
In recent years there has been potential increase in the use of alkaline protease as industrial catalysts. Many major industrial and commercial applications, such as food and textile industries, and medical diagnoses, are highly dependent on the protease enzyme. In the cell immobilization technique, the free movement of microorganisms is restricted in the process, and a continuous system of fermentation can be used. In the present work, this technique has been used for alkaline protease production using different carriers, such as chitosan, corn cob and corn tassel. Enzyme activity before immobilization (72 h) was 78.3 U/ml. Corn cob, with 65% immobilization capacity and the highest enzyme...
Cobalt -mediated radical polymerization of vinyl acetate in a packed column system: simultaneous effective control of molecular weight, separation, and purification
, Article Journal of Polymer Research ; Volume 29, Issue 12 , 2022 ; 10229760 (ISSN) ; Dadkhah, A. S ; Kohestanian, M ; Mahdieh, A ; Semsarzadeh, M. A ; Sharif University of Technology
Springer Science and Business Media B.V
2022
Abstract
The simultaneous control of the molecular weight, separation, and purification of polyvinyl acetate was achieved using a cobalt-mediated radical polymerization (CMRP) in a packed column with silica gel particles (PC-CMRP). The controlled radical polymerization of VAc in the packed columns was evaluated from the linear time dependence of Ln[M]0/[M], linear increase of molecular weight with the increase in conversion, and narrow molecular weight distribution. PC-CMRP method was used to produce high-purity polymers with controlled molecular weight and narrow molecular weight distribution without requiring additional purification steps. The high ability of silica gel particles to adsorb free...
Synthesize of Graphene Nanoribbons with a Non-Zero Energy Band Gap for Inactivation of Alive Cells Using Infrared Irradiation
, M.Sc. Thesis Sharif University of Technology ; Akhavan, Omid (Supervisor)
Abstract
Graphene is a one layer atom thickness and zero energy gap so for using it in nano electronic and transistors baised on graphene it's energy gap should be opened.one of the methods for opening graphene band gap is creating nano scale boundaries or synthesize graphene nanoribbons. One of the new methods for graphene nanoribbon synthesize is longitudinal opening of carbon nanotube. In this thesis graphene nanoribbons synthesize with this method and analyze with AFM and Raman spectroscopy. Carbon nanotubes also have energy gap and IR absorption recently they used for living cell destruction. In this thesis we synthesize graphene nanoribbons and analyzing their optical absorption and use it for...
Fabrication of Graphene/TiO2 Nanowalls as Visible Lights Photocatalysts
, M.Sc. Thesis Sharif University of Technology ; Akhavan, Omid (Supervisor)
Abstract
TiO2 is known as a photocatalyst in near UV-Visible light region with better efficiency compared to other semiconductor photocatalysts. Many attempts have been done to increase the efficiency of this photocatalyst. also, application of 2D carbon nanostructures namely graphene for increasing the photocatalytic activity of TiO2 has shown positive results.
In this research, we first synthesized Graphene Oxide (GO) suspension by exfolation of graphite oxide suspension. then we fabricated TiO2 thin films on glass substrates by so-called sol-gel method. finally we fabricate Graphene Oxide/TiO2 nanowalls composite films as a photocatalyst in visible light. X-ray photoelectron spectroscopy...
In this research, we first synthesized Graphene Oxide (GO) suspension by exfolation of graphite oxide suspension. then we fabricated TiO2 thin films on glass substrates by so-called sol-gel method. finally we fabricate Graphene Oxide/TiO2 nanowalls composite films as a photocatalyst in visible light. X-ray photoelectron spectroscopy...
Fabrication of Graphene-WO3 Nanocomposites as Photocatalyst in the Visible Light Region
, M.Sc. Thesis Sharif University of Technology ; Akhavan, Omid (Supervisor)
Abstract
WO3 is known as a photocatalyst in the visible light region, but with lower efficiency compared to more interesting semiconductor photocatalysts such as TiO2 and ZnO. Many attempts have been done to increase the efficiency of this photocatalyst by incorporating metal and metal oxide nanoparticles or recently carbon nanotubes.On the other hand, application of graphene, as an unrolled carbon nanotube, for increasing the photocatalytic activity of TiO2 and ZnO has shown positive results. Furthermore, it was reported that such semiconductor photocatalysts (and very recently WO3) can photocatalytically reduce the chemically exfoliated graphene oxide sheets under UV-vis irradiation.
In this...
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Synthesis of Graphene Nanosheets for Stem Cells Applications
, M.Sc. Thesis Sharif University of Technology ; Akhavan, Omid (Supervisor)
Abstract
Graphene nanogrids fabricated by graphene nanoribbons obtained through oxidative unzipping of multi-walled carbon nanotubes, used as two-dimensional selective templates for accelerated differentiation of human mesenchymal stem cells (hMSCs), isolated from umbilical cord blood, into osteogenic lineage. The biocompatible and hydrophilic graphene nanogrids showed high actin cytoskeleton proliferations that coinciding with patterns of the nanogrids. The amounts of proliferations found are slightly better than proliferation on hydrophilic graphene oxide (GO) sheets, and significantly higher than non-uniform proliferations on hydrophobic reduced graphene oxide (rGO) sheets and polydimethylsiloxane...
Identifying the risks of Iranian Knowledge BasedFirms Using Fault Tree Analysis (FTA)
, M.Sc. Thesis Sharif University of Technology ; Fattahi, Omid (Supervisor)
Abstract
Knowledge Based Firms are considered to be important for the economic development of a country in regards to both employment growth and innovative activity. The latter is believed to contribute significantly to the increase in productivity and therefore the competitiveness of Iran’s economy. This study contributes to the above literature by investigating the factors that are believed to treat the growth of such firms in Iran. The purpose of this study is to identify functional risks of vital signs monitors via Fault Tree Analysis (FTA) method to use as a guide for manufacturers to identify and control hazards. Therefore, 30 knowledge based firms were selected as sample. Then, based on a...
Synthesis of Graphene from Waste by Chemical Exfoliation and Study of It’s Physical Characteristics
, M.Sc. Thesis Sharif University of Technology ; Akhavan, Omid (Supervisor)
Abstract
One atom thick layer of pure carbon in bonded and hexagonal lattice is named graphene. graphene has unique mechanical, optical, thermal and electrical properties and because of these properties has grabbed attention. graphene has been made from high pure graphite by different methods such as CVD(chemical vapor deposition) , chemical exfoliation , micromechanical cleavage and colloidal suspension. through these methods, green methods for synthesis of graphene, using eco-friendly reductants during synthesis of graphene instead of hydrazine and recently using waste(not graphite) are attractive for synthesis of graphene. Following this idea , a group has produced graphene from wastes such as...
The Use of Hydrogen Rich Water for Synthesis of Hydrogenized Graphene and Investigation of Its Properties
, M.Sc. Thesis Sharif University of Technology ; Akhavan, Omid (Supervisor)
Abstract
Graphene is a two dimensional lattice which is created from carbon atoms. Having special feature, it has such various medical usage, for example in diagnosing and treating cancer. Adding a particular factor to graphene could improve their efficiency. In comparis on with graphene itself, graphene oxide and reduced graphene oxide are much more successful in diagnosing and treating than others because of their higher hygroscopic. Recent studies state that hydrogenized combinations including hydrogenized graphene show desired results. Due to its higher hygroscopic and the possibility of adherence to the cells, hydrogenized graphene could be very effective in diagnosing and treating the sarcomas....
A Meta Heuristic Approach for Design of a Network System in Mass Customization
, M.Sc. Thesis Sharif University of Technology ; Fattahi, Omid (Supervisor)
Abstract
This study discusses about mass customization and optimization of supply network in which both goal considering to set the flow of raw material and final product to satisfy the customer demand. The mass customization is more important concept in this study, so that this goal is placed to the first objective. In this research, the model which contained both goal is presented. The model focus on mass customization and try to satisfy various products demand, which constitute 3 kind of speed demands. Each product can satisfy in 3 way: fast, normal, slow.In the first model the new approach present in which the speed affects all of supplying, manufacturing and distributing system. The system try...
Synthesis of Graphene Oxide and Study of its Fluorescence Properties
, M.Sc. Thesis Sharif University of Technology ; Akhavan, Omid (Supervisor)
Abstract
Graphene oxide is a single sheet of Carbon atoms which has been arranged on a two-dimensional honeycomb lattice. Functional groups such as epoxy, carboxyl and carbonyl are located on basal plane and at the edges of graphene oxide and they localize electrons on the surface of graphene oxide and open band gap in its band structure. Pure graphene has zero band gap, so existence of fluorescence properties is unlikely; but graphene oxide has fluorescence properties due to band gap in its band structure. Fluorescence properties of graphene have been used in live cell imaging and drug delivery, so study and increasing of fluorescence properties is significantly important. The purpose of this...
A Novel Reliability Model for Information Technology Web services
, M.Sc. Thesis Sharif University of Technology ; Fatahi Valilai, Omid (Supervisor)
Abstract
The Internet is often used for communication-based applications such as online banking, stock trading, and shopping where service interruption is unacceptable. Thus, analysis of the impact of the failures of hardware, software, and related services’ performance quality of the service provided to users is of importance to designers and managers in these functions. In this study, we developed a strategy to the design of a dynamic combination of file servers with the aim of providing reliability and SLA. At first, we examine the reasons for the violation of service level in file host services and datacenters, and then we introduce the criteria to measure the violation of service level on the...
Development of a novel solution to enable integration and interoperability for cloud manufacturing
, Article 6th International Conference on Changeable, September 2016 through 6 September 2016 ; Volume 52 , 2016 , Pages 6-11 ; 22128271 (ISSN) ; Fatahi Valilai, Omid ; Sharif University of Technology
Elsevier B. V
2016
Abstract
Nowadays, manufacturing enterprises have been faced with a globalized competitive environment. In this fierce condition, Cloud Manufacturing paradigm emerged as a promising concept for competition. It provides effective solutions and tools for manufacturing enterprises to collaborate in globalized market. The revolution that Cloud Manufacturing has created is based on the redefinition of the classic methods to those which are appropriate for todays' modern and globalized manufacturing environments. In parallel with cloud-based revolution, the expansion of internet-based technologies has been started. These technologies previously have been applied in many fields and resulted in...