Sharif Digital Repository

Nowadays, advanced and inexpensive pre-clinical methods for investigating the effects of anti-cancer drugs are expanding. One of the latest three-dimensional laboratory modeling for evaluating the effects of drugs is the use of tumor-on-chip technology, which actually models the physiological system of the body through three-dimensional scaffolds, multicellular cultures, and shaped vascular systems. In this study, three-dimensional culture of cancer cells was performed in the form of spheroids. A chip of U-shaped microstructures with and without gaps was used to trap cells and form cancer spheroids. We simulated the simultaneous effect of drug and oxygen concentration distribution inside the... 

The synthesis, characterization, structural and computational studies of mononuclear Re(I) tricarbonyl complexes of 2,2'-bipyridine (2,2′-bpy) and 2,9-dimethylphenanthtroline (2,9-Me2Phen), [Re(CO)3(NN)(X)], where NN=2,2′-bpy,X=Br (1) and X=–ONO (3); NN=2,9-Me2 Phen, X=Br (2) and X= –ONO (4), were reported. The complexes characterized by crystallographic and spectroscopic methods and elemental analyses. In each complex, the Re(I) center showed the distorted octahedral geometry. Single crystal X-ray diffraction data revealed the endo-nitrito (κ1–ONO) coordination in complexes 3 and 4. It has been shown that the replacement of the bromo ligand in complexes 1 and 2, either by AgOTf/NaNO2 in a... 

VLSI technology scaling has resulted in the integration of a larger number of cores in a single chip in successive technology nodes, offering a great potential to realize task-level redundancy for reliability enhancement in safety-critical applications. However, since battery technology no longer advances commensurately with integration density, multi-core platforms may have limited utility in battery-powered embedded systems. In this thesis, we propose an energy-budget-aware reliability management (enBudRM) method for multi-core embedded systems featuring hybrid energy source (with renewable and non-renewable energy sources). Our method is composed of two phases. In the offline phase, we... 

In this project three models addressed before in the references are reviewed and the stability margins of radome error slope obtained by analytical method. Then a new model who is usefull in practical applications presented. Because of complication of this model the model is simplified and stability margins for radome error slope derived in simplified model. It is also shown that simplified applicative model is similar to model purposed in ref. [6]. Then a PD controller designed to stabilize some of models reviewed in chapter 3. The equations derived before verified in continuation of the project. The effects of parameters on the stability of missile analysed by equations derived in chapter... 

Three-dimensional network-on-chip (3D NoC), the combination of NoC and die-stacking 3D IC technology, is motivated to achieve lower latency, lower power consumption, and higher network bandwidth. 3D NoCs reduce length of communication link and transmition delay by die stacking. However, the length of heat conduction path and power density per unit area increase as more dies are stacked vertically. High temperature results in longer propagation delay and increases the leakage power. If heat production in the chip is not managed, low cooling rate for these layers is a threat for the chip performance and reliability. To solve the thermal problems, thermal management schemes were proposed in the... 

The goal of this research is to convert letter to phoneme using deep neural networks. As the deep neural networks are among the best methods for speech and text processing (The highest accuracy in converting text to letter in English language is obtained by using deep neural networks too.), multilayer deep neural networks are used in this research to increase the accuracy. It should be noted that deep neural networks have not been used for converting text to phoneme in Persian language before. In this research a rule based alignment method based on our preposed rule is presented and achieved an accuracy more than 98%. Several approaches for converting word to grapheme with emphasis on the... 

Plasma Electrolytic oxidation has recently been known as a new technology in surface engineering. It is one of the low-cost techniques used for improving corrosion and wear resistance in Al-Mg alloys. The purpose of this study first is to attach aluminum and magnesium alloys safely and without any defects, and then finding the optimum coating condition in connection line to achieve most possible corrosion resistance. For this purpose, first of all optimization of Al-Mg alloys friction stir welding (FSW) condition is required. After required investigations, it was shown that the weld created between Aluminum and Magnesium sheets by the cylindrical pin moving in a rotational speed of 550... 

The advancement of Cyber-physical Systems (CPSs) has attracted attention to Mixed-Criticality Systems (MCSs), both in research and industrial designs. Mixed-criticality systems (MCSs) integrate different types of functionalities with varying levels of criticality onto the shared computing platform. The scheduling algorithms for MCSs must guarantee that all high criticality tasks are completed by their deadlines in different operation modes of the system. In addition to certification, as multi-core platforms are becoming a dominant trend in designing MCSs, simultaneous energy and reliability management, and Quality of Service (QoS) are other significant challenges in designing MCSs. Indeed,... 

Modeling and performance evaluation of the real time distributed systems is a significant problem. Stochastic activity network is one of the high level models used for this purpose. This network is an extension of generalized stochastic Petri net which is more powerful and flexible than other Petri net extensions. Checking the satisfiability of properties such as performance, dependability and user's expected properties is considerable in these models. Thus, using the approaches and generating modeling and model checking tools with the mentioned purpose is attractive. A model checker automatically checks the correctness of the system behaviors as properties against the model by getting the... 

This study has focused on the important problem of landing on a planet as an important current and future space mission. In this regard, dynamics modeling and integrated state estimation and control problems have been investigated in different views. To this aim, first a novel concurrent representation for translational and rotational kinematics has been developed based on the extension of modified Rodrigues parameters to dual space. This parameter set, called dual modified Rodrigues parameters (DMRP), is then utilized to establish an integrated roto-translational dynamic. The proposed DMRP-based kinematics and dynamics have been verified via comparison to traditional methods of... 

Prevalent deployment of Distributed Energy Resources(DERs) in the demand side of electrical energy grids has several advantages such as greenhouse gases emission reduction, mitigation of power losses in the distribution grids and abatement of the dependency on the wholesale generation companies. At the same time, it paves the way for the advent of local interactive energy trading frameworks. In the following thesis, a distributed data-driven algorithm is developed for market-clearing in a community-based local energy market. The social welfare maximization is considered as the objective of the energy trading. The production and demand of electricity are the decision variables of sellers and... 

Understanding biological systems requires extensive knowledge of individual parameters, and to study the processes of cell differentiation and cell behavior, a suitable environment must be created with the physiological conditions of the human body. For this purpose, with the knowledge of microfluidics, a microenvironment can be provided to study the behavior of cells on a small scale. The use of bone tissue model microfluidic chips is an alternative and new method in which it is possible to study the behavior of cells to differentiate into bone and to examine the toxicity of drugs, which in itself can help in the effective and successful treatment of these cases show. Therefore, in this... 

The main topic of this research is the navigation and control of a free-flying satellite with a robot manipulator while transferring and placing cargo on a space station. After connecting the cargo module, astronauts and robots need to deliver the available loads to the desired modules in a space station. Capturing an object or cargo is a critical issue studied extensively so far. However, delivery and placing of the cargo at the target point have not been investigated yet, to the best of the author’s knowledge; hence, this is a primary motivation for conducting the proposed research. After capturing the payload, the position and attitude of the manipulator with respect to the station’s... 

Cardiovascular disease (CVD) currently remains a considerable challenge for clinical treatments. CVDs account for N17.5 million deaths per year and will predictably increase to 23.6 million by 2030. The main purpose is to create human model systems to study the effect of disease mutations or drug treatment on the heart. In addition, engineered cardiac tissues are considered promising candidates to be transplanted to improve the function of diseased hearts. For engineered active tissues/organs, 3D bioprinting can fabricate complex tissue architecture with a spatiotemporal distribution of bioactive substances (cells, growth factors, and others) to better guide tissue regeneration. However,...