Sharif Digital Repository

Cancer is a life-threatening group of diseases that arises from the uncontrolled growth and division of cells in the body. Treatment options for cancer include surgery, chemotherapy, radiation therapy, immunotherapy, targeted therapy, and hormone therapy. However, resistance to anticancer drugs can develop through a variety of mechanisms, such as the upregulation of drug efflux pumps and alterations in DNA repair mechanisms. One common mechanism of drug resistance is through changes in metabolism, where cancer cells switch to alternative metabolic pathways to survive and evade the effects of anticancer drugs. The development of new drugs targeting specific molecules and pathways involved in... 

With the increasing emphasis on production of various chemicals by biotechnology industry, the establishment of optimal cell factories for the maximum production of a specific chemical product will be a serious challenge in large-scale production in this industry. Metabolic engineering is a branch of biochemical engineering that has been developed to achieve this and the approaches in it seek to address this challenge. In this study, focusing on increasing production of fatty acids by yeast cells of Saccharomyces cerevisiae, and using a combination of computational and laboratory methods to present a methodology for the optimal design of culture media. Thus, using the constraint-based... 

Malaria is one of the most important infectious diseases in the tropical and subtropical regions of the world and is caused in humans by the bite of the female Anopheles mosquito of five species of Plasmodium. According to the World Health Organization, about 229 million people worldwide were infected in 2019 by the disease, and 409,000 people died from the disease. Resistance of the parasite against drugs and resistance of vectors to insecticides and larvicides, which prevents the elimination and eradication of malaria, shows the need for new strategies, such as having an effective vaccine against this disease. In the second generation of vaccines, to develop malaria vaccines, recombinant... 

One of the major concerns in the use of light flying objects is propulsion for cruise and take off from land. Creating propulsion force is important in such way that no excessive weight is introduced, especially in case of UAVs. A common trend for propulsion in light flying objects is using propellers. Propellers are commonly driven by an external motive force and due to this force and their geometry, they convert energy from this motive force into the momentum of fluid in which they are immersed as a result a lift force is generated.In the present work, trend of propeller design with optimum performance is introduced with use of vortex theory, optimum energy loss condition or Betz condition... 

Up to early seventies, Gas turbine combustor design was very time consuming and costly process including trial and errors through test rigs. Over the time analytical-experimental relationships take place as one of the key rules in the design processes. With the increasing power of computer calculations, computational fluid dynamics find its way in the procedure. Obtaining a deeper understanding of flow conditions and geometry inside the chamber, a great reduction in production time and cost of revisions to rigs and samples were achieved. Finding a precise prediction of polluting elements like NOx (less than 10 ppm) after many run hours and enormous computing resources, CFD methods must... 

Fed-batch fermentation is a valuable and cost-effective method for bio-based production of various products such as ethanol, which has various applications in various industries.In recent years, bioethanol production has been given special attention in many countries. For this reason, the mathematical modeling of production of these products is very important for their optimal and cost-effective production. Given the transient and dynamic nature of fermentation and its specific complexity, mathematical modeling of fed-batch bioreactors is difficult and complicated. In this research, an unstructured model was used to predict the production of ethanol from blackstrap sugar cane molasses based... 

Although the moment frame can show deformable behavior against seismic loads, but its flexibility and low stiffness, especially in tall structures, cause the governance criterion to be designed. The use of eccentrically braced frames was able to solve the displacement problem to some extent, because it has the characteristics of both flexural frame systems and conccentric bracing. Different methods have been proposed to eliminate residual displacements in this type of system, one of which is the use of post tensioned cables. The aim of this study was to investigate the seismic behavior of a steel structure with a eccentrically braced frame system with post tension cable.The cables are anchor...