Sharif Digital Repository

This project presents algorithms for intelligent control of the viral load in a HIV-1 infection model. The first part of thesis was dedicated to the study of the three states model adopted to describe the HIV-1 infection. A sensitivity analysis of the model parameters was described and computer simulations were provided to show the influence of the parameters explicitly. Then, an internal model control based on neural networks was implemented on the introduced infection model with including the RTIs and PIs drugs efficacies as control input. A stable adaptive neuro-control approach was presented for affine in the control nonlinear dynamical systems, whose nonlinearities were assumed to be... 

Vaccination is one of the ways of disease control and prevention, which not only protect individuals against the disease, but also reduce the disease spread rate. Mass vaccination of individuals is not always possible due to the high cost and limitation of immunization resources. Therefore, researchers are always seeking solutions to find the persons that their immunization may have a greater impact in reduction of disease spread rate. The advent of network epidemic models and the possibility of removal the secured nodes in those models, showed that this problem is equivalent to finding a limited set of individuals that their removal will eliminate or minimize the number of people at risk of... 

This thesis focuses on the design procedures of a Type Test tunnel intended to be used for performance verification of large electrical generator air to water coolers with a dimension of 3*3 meters. Using guidelines of related standards the tunnel was designed and modified to satisfy the requirements set by installation site and manufacturing limitations. As this required some deviations from standard guide lines, the correctness of the final design was evaluated using numerical computation of flow inside the tunnel. The tunnel structure and its internal parts were analyzed for strength and deflections. Using the results of numerical computations, the other main equipments of tunnel such... 

Edit distance or Levenshtein distance is one of the most fundamental problems in computer science and engineering to measure the dissimilarity between strings.This problem is solvable in O(n^2) time using dynamic programming and in 2015 it was conditionally proven that no truly subquadratic time algorithm (\textit{i.e.}, O(n^{2-ε})) exists for edit distance.Since 2001, approximating edit distance within a constant factor was recognized as one of the biggest unsolved problems in the field of combinatorial pattern matching.This thesis designs seven approximation algorithms for edit distance and its related problems.Firstly, two quantum approximation algorithms are designed with constant... 

Three-phase electronic loads are used to test the performance of various electrical devices such as power supplies, generators, and transformers. Conventional electronic loads are composed of passive components that consume the energy, so have low power density and efficiency and to manage the produced heat, massive cooling systems are required. Nowadays, to increase efficiency and power density, three-phase regenerative electronic AC loads have been developed. To return energy to the grid and control the input power factor, the structure of these loads is based on back-to-back converters. In this project, a 35 kVA three-phase regenerative electronic AC load is designed. To control the power... 

There is an effective and functional connectivity between the central nervous system and the cardiovascular system, which is controlled by the autonomic nervous system. Investigating this connectivity and its direction can provide valuable insights into their functioning. To examine causal and directional relationships, EEG and ECG signals, which contain useful information about the activities of these two systems, are utilized. Granger causality is a popular method for estimating effective linear connectivity. However, the assumption of linearity in effective connectivity is not always valid, as nonlinear interactions also exist between the nervous and cardiovascular systems. Estimating... 

The conventional bearing-only tracking solutions are based on Kalman filter. Whenever the problem equations are nonlinear, Extended Kalman Filter (EKF) or more complicated methods are used necessarily. However, EKF suffers of being biased and unstable. Here a new recursive method based on a linear modeling of the problem is proposed, the method does not need an initial guess and outperforms the Kalman filter in the terms of accuracy, complexity and stability. Furthermore, input information needed for the proposed tracking filter is just the observer position, time and value of each angle measurements and the computation load is less than even a simple EKF. mathematical analysis, as well as... 

In this work, Hough detector has been compared with optimum detectors. We consider 2-D range-time data space, which is constructed by storing the radar returns from different range cells during several successive scans. In this space, target trajectory can be modeled as a straight line for short time intervals, and can be extracted by applying Hough transform transcendentally. In this work, a new detection method based on the likelihood ratio in the data space with Gaussian noise is introduced. ALR and GLR processors have been designed. Then formulas for probability of detection and false alarm rate is calculated, and verified via simulations. A new criterion for estimation quality is... 

Anaerobic digestion is a useful process that is very important, addition to producing methane as energy source, it can be used for treatment of solid waste and sewage sludge. This process due to the presene of chemical and biological reactions and abundant chemical species, is very complicated and sensitive, so it is very unstable against any kind of change. as for the large importance of the process, we need control and optimization. In order to improving the performance of the process and increasing biogas and methane production, we should control and optimize the process. ADM1 is principal and the most accurate model for this process, a variety of reduced order models used to design... 

Why firms does not submit several steps in their bids curve? In this paper, we present a mathematical model for the behavior of power plants in a Pay-as-Bid auction market. According to this model, in the case that the power plant has a fixed marginal cost, the optimal behavior for him is to offer only one price, but in the case of linear marginal cost, bidding one price is not an optimal price, and with increasing the slope of this function, the number of steps and their price level will increase. We also show that increasing the level of competition in the market will force the plants to lower the price level and the number of steps. The model of this paper also predicts the factors... 

Obtaining polymers with desired properties is very important from industrial point of view. Weight average molecular weight and polydispersity are two important polymer properties. It is also important to obtain a high monomer conversion. In this thesis production of polyvinyl acetate is considered. Under special conditions, the vinyl acetate reactor dynamics become oscillatory which makes the reactor control difficult. For obtaining polymer with desired properties, an objective function which includes weight average molecular weight, polydispersity and monomer conversion has been defined. Then by minimizing this objective function the optimal temperature trajectory is obtained. In this... 

Modeling and Control of Ethylene Oxide Reactor In this thesis, steady and dynamic modeling of an ethylene oxide fixed bed reactor has been studied and one dimensional pseudo homogeneous model was used for simulating the reactor. Kinetic parameters were obtained by minimizing an object function and using the genetic algorithm. A good agreement is observed between simulation and experimental results. In steady state condition, the influence of some parameters such as shell temperature, feed rate were investigated on the performance of the reactor. The heat of reaction is used to produce steam. A dynamic model for steam drum was also considered and used for control purpose. A PI controller was... 

Most of Final properties of polymers such as morphological characteristics are related to molecular weight distribution (MWD) and particle size distribution (PSD). It is possible to obtain the desired properties by controlling of these indices. In this work, modeling, simulation, and control of final properties of styrene have been considered. First, kinetic of reaction has been investigated which is a free radical type. Molecular weight distribution has been calculated by using moment method. Next, population balance equation (PBE) has been used to model PSD. For this system, mass, energy, and moment conservation equations are a set of stiff ordinary differential equations (ODEs). PBE is a... 

Time delay systems may arise in practice for a variety of reasons, such as autonomous systems (without feedback control), and the delay is the result of an intrinsic property of the system. Sometimes the delay results from feedback control action, instead from the system itself; that is, due to the nature of the system, the feedback is delayed. Another type of delays of similar effects may be incurred due to delayed measurements. In both delayed control and delayed measurement, the delay is usually considered undesirable, which has the tendency to deteriorate the system performance or even destabilize the system.

In this thesis, three types of adaptive controller are proposed for... 

This thesis focuses on modeling, simulation and control of bulk polymerization of styrene in an autorefrigerated reactor where the generated heat is removed by heat of vaporization of the monomer. By means of two mathematical models for the kinetics of reaction, static and dynamic simulations were performed. For this purpose the equilibrium points were calculated using the steady state analysis, and then the reactor temperature was controlled at the unstable point using PI and adaptive generalized predictive controller (AGPC). In order to implement the GPC scheme a process model is required to provide the process output estimate over the prediction horizon. For this purpose an auto... 

In this thesis, simulation and control of intracranial pressure and temperature has been studied. Common methods for control of intracranial pressure and temperature are hypothermia treatment and drug therapy. Hypothermia is a clinical treatment for cooling the patient body with cold water-circulating blanket to decompress intracranial pressure by decreasing body temperature. In order to simulate the patient body, two mathematical models for single-input single-output and multi-input multi-output systems that are proposed in the literature are chosen. The thermodynamic- hemodynamic model was simulated as single-input single-output system and the thermodynamic- hemodynamic- pharmacokinetic... 

In this study design of controller for a nonlinear system in the presence of state observer was investigated. First, nonlinear observers including non-adaptive and adaptive versions and their design procedures were studied. Then nonlinear adaptive controllers, based on sliding mode, feedback linearization and back-stepping techniques were implemented in the presence of observer dynamics. Two versions of adaptive law were proposed for unknown parameters identification in feedback linearization and sliding mode techniques. A new adaptive law was proposed to relax the restrictive condition that is used in adaptive observer design. The closed loop stability of back stepping technique was studied... 

Biotechnology is one of the fields that has had great advances in the past decades, and therefore controlling biological processes (bioreactors) is considered as an important issue. The purpose of current thesis is designing an adaptive controller for a bioreactor by considering input constrain and proving the stability of closed loop. A standard bioreactor has been chosen for this purpose. First a non-adaptive controller has been designed. Then an adaptive controller is designed and implemented on a bioreactor in the presence of input constraint, because in practice the system parameters are unknown. Finally by applying disturbance to the system, it has been shown that the proposed control... 

Immediate control of pandemic influenza to avoid casualties and financial losses is an important issue. In this thesis, two types of controllers including optimal controller and adaptive generalized predictive controller based on linear input-output model, with vaccine, treatment and quarantine being controlling variables, have been used to control influenza. Each controlling methods were investigated for different states including single-input single-output and multi-input single-output. Single-input single-output and multi-input single-output models are identified as online and offline using least squares method. Since it is difficult to exactly identify the model parameters, especially at...