Sharif Digital Repository

The Reliability of substation structures with consideration of earthquake uncertainties is one of the most important subjects in structural analysis in recent years. In this project we first introduce IEEE-693-2005, which is the most effective and comprehensive seismic design code for electronic substations. Also in second chapter the rudimentary aspects of Reliability Theory and methods for evaluating the reliability of substation structures is introduced. Then with modeling the most common and most important electronic substation devices in Iran, with consideration of all seismic parameters and their uncertainties, the reliability of these structures evaluated. In this project for... 

This research deals with the problem of scheduling independent preemptive jobs on identical parallel machines, to minimize the total completion time (makespan). The transportation of an interrupted job from a machine to another machine requires considering a constant transportation delay i.e., Pm|prmp(delay)| Cmax. This delay is called transportation delay. We propose a Mixed Integer Linear Programming formulation for the research problem in case of two machines i.e., P2|prmp(delay)| Cmax. Since the research problem is shown to be NP-hard, a particle swarm optimization (PSO) algorithm is applied to solve the problem approximately. Based on the frequency of using local search procedure, three... 

Recently various speaker adaptation methods in HMM-based speech synthesis are proposed. The importance of adaptation techniques is that we can design a system in which speech is generated with high quality and target speaker characteristics through limited adaptation data sets.
In this research, we focus on adaptation based on clustering and develop a new and novel method using eigenvoices in order to adapt a new speaker. We employ this approach for the first time in HSMM-based speech synthesis systems and its goal is to reduce the parameters and adaptation data of the system. In our proposed method, first some speaker dependent models are trained. For each model we combine the... 

Today, computer simulations are employed prevalently by researchers to understand biological processes. The tendency to use computational methods has been increased recently due to the high costs and errors of experimental methods. Integrins are membrane proteins that mechanically attach cells to the extra cellular matrix (ECM) and derive some behaviors such as cell migration. Moreover, integrins have biochemical functions. They transduce environment signals and trigger chemical pathways. As a result, integrins regulate cell shape, motility, etc. The investigation of integrin behavior in a real environment is very difficult due to the presence of many other proteins that interfere with the... 

Folded protein experience several conformational substates. Each substate reperesents a minimum in the free energy surface of the system. Since Myoglobin is the smallest protein that can reversibly bind to gas molecules and, it can be used as prototype for more complex systems.IR pecrtum of CO inside of myolgobin shows that distinct conformational substates can occur. It was shown that Histidine residue inside heme pocket plays an essential rolle in structural properties of substates. In this study, we used molecular dynamice simulation together with umbrella sampling method to obtain free energy profile of MbCO system. The configuration of distal Histidine (His64), CO and Heme is studied...