Sharif Digital Repository

Folded protein experience several conformational substates. Each substate reperesents a minimum in the free energy surface of the system. Since Myoglobin is the smallest protein that can reversibly bind to gas molecules and, it can be used as prototype for more complex systems.IR pecrtum of CO inside of myolgobin shows that distinct conformational substates can occur. It was shown that Histidine residue inside heme pocket plays an essential rolle in structural properties of substates. In this study, we used molecular dynamice simulation together with umbrella sampling method to obtain free energy profile of MbCO system. The configuration of distal Histidine (His64), CO and Heme is studied... 

This thesis investigates nonlinear rolling of ships and effect of anti-rolling tanks. For this purpose numerical method is used. For studying this phenomenon, a program was developed in Simulink module of commercial software, MATLAB and roll motion has been simulated. The program has been developed so it can be used for displacement commercial vessels with a typical hull form and the simulated tank is a U-shape type tank. Simulation is 1-DOF and for rolling in regular waves with different encounter angel except for head sea and following sea. Results are included of roll degree, angular velocity and acceleration of ship and tanks fluid roll, encounter wave moment on ship and moment imposed... 

Structures with time-varying electromagnetic properties can potentially yield non-reciprocity, amplification, harmonic generation, and other interesting wave propagation phenomena. To date, some studies have dealt with time-varying media and circuits, including time-varying optical ring resonators having degenerate travelling wave resonances. In time-varying ring resonators, the clockwise and counter clockwise resonances lose their degeneracy, and non-reciprocity is observed. One of the main challenges of such research is the need to induce time-variations in the entirety of the resonator or structure, which makes their implementation very limited or impossible in practice. The purpose of... 

One of the most important factors that make breast cancer such a dangerous and deadly disease is its hidden. One of the most important methods of revealing this disease is imaging. There are different types of imaging to reveal cancerous tissues (tumors), such as ultrasound, mammography, X-ray, etc. Ultrasound imaging is a cheap, convenient and accessible imaging. The aim of this project is to provide a breast cancer detection system that uses the images taken with this method according to the characteristics of ultrasonic imaging. Regarding cancer diagnosis, doctors identify the tumor with the help of their personal experience, which is based on the characteristics of the tumor image. In... 

The Self-Consolidating (Compacting) Concrete (SCC) is a high performance concrete. Due to preventing it from segregation, SCC is known by its need to higher dosage of super plasticizer and viscose modifying agents. This increases the cost and reduces the popularity of SCC in construction industry. In this thesis, the production of Rice Husk Ash (RHA) from a controlled burning process using a special designed furnace, and cement replacement feasibility in the concrete mixture by low cost RHA, as an active pozzulanic additive have been investigated. Finding an appropriate ratio of replacement with cement for RHA and further effects on mechanical properties of SCC have been evaluated. The... 

Bearing capacity of piles depends on many factors among which geometrical properties of piles, soil type, and strength properties of soil are of great importance. Based on these parameters, several approaches have been developed in order to overcome the uncertainty in the prediction of pile bearing capacity. Studies carried out in this area or research can be divided into two main categories: first, laboratory based approaches, and second, numerically based approaches. The research followed in the present study is based on numerical modeling. In this study, a single pile is initially modeled in the axisymmetric configuration and its bearing capacity is determined. The results of the model... 

% of human blood makes up of plasma, that this plasma is a rich source of proteins that can be used as biomarkers for a variety of clinical diseases and laboratory research, therefore, it is necessary that the plasma be separate by a high purity percentage. Using a centrifuge It is a common method used to separate plasma from blood, but because it requires large equipment and a large volume of blood, as well as stress caused by centrifugal force, increases the probability of damage to the biomarkers, so it has been tried today that Use methods that are easy to transport and require a small amount of blood. The idea of using the microfluidic device has been put forward for the purpose of... 

Corrosion study of the reinforced concrete is one of the most commonly investigation for the construction in civil engineering. The corrosion of embedded steel for the structures in the marine area like the Persian Gulf Sea Water needed considerable attentions. Presence of chlorides and decrease of pH in pores reinforcement depth of concrete is a serious problem. Research the corrosion rate in reinforced concrete system using fibers with a rebar is investigated. Cellulose and Carbon fiber materials are used as inhibitors. The addition of small quantities of these materials into the concrete mixture, will change the concrete permeability and the corrosion resistance rate. Tests demonstrate... 

The role of the lumbar muscles in maintaining posture and balancing externally applied loads has been studied for many years.preliminary studies used electromyograpy (EMG) to establish a relationship between trunk posture and muscle ativity.so developing a better undrestanding of the functional role of those muscles. Determination of lumbar muscle forces, will have an important role in reducing low back pain I future.For this reason,reaserchers have done many studies for understanding the resistence and function on the musulosketal system bye using of various protocls and have utilized of various biomechanical models for determining the effects of applied externally loads on lumbar... 

The Reliability of substation structures with consideration of earthquake uncertainties is one of the most important subjects in structural analysis in recent years. In this project we first introduce IEEE-693-2005, which is the most effective and comprehensive seismic design code for electronic substations. Also in second chapter the rudimentary aspects of Reliability Theory and methods for evaluating the reliability of substation structures is introduced. Then with modeling the most common and most important electronic substation devices in Iran, with consideration of all seismic parameters and their uncertainties, the reliability of these structures evaluated. In this project for... 

This research deals with the problem of scheduling independent preemptive jobs on identical parallel machines, to minimize the total completion time (makespan). The transportation of an interrupted job from a machine to another machine requires considering a constant transportation delay i.e., Pm|prmp(delay)| Cmax. This delay is called transportation delay. We propose a Mixed Integer Linear Programming formulation for the research problem in case of two machines i.e., P2|prmp(delay)| Cmax. Since the research problem is shown to be NP-hard, a particle swarm optimization (PSO) algorithm is applied to solve the problem approximately. Based on the frequency of using local search procedure, three... 

Recently various speaker adaptation methods in HMM-based speech synthesis are proposed. The importance of adaptation techniques is that we can design a system in which speech is generated with high quality and target speaker characteristics through limited adaptation data sets.
In this research, we focus on adaptation based on clustering and develop a new and novel method using eigenvoices in order to adapt a new speaker. We employ this approach for the first time in HSMM-based speech synthesis systems and its goal is to reduce the parameters and adaptation data of the system. In our proposed method, first some speaker dependent models are trained. For each model we combine the... 

Today, computer simulations are employed prevalently by researchers to understand biological processes. The tendency to use computational methods has been increased recently due to the high costs and errors of experimental methods. Integrins are membrane proteins that mechanically attach cells to the extra cellular matrix (ECM) and derive some behaviors such as cell migration. Moreover, integrins have biochemical functions. They transduce environment signals and trigger chemical pathways. As a result, integrins regulate cell shape, motility, etc. The investigation of integrin behavior in a real environment is very difficult due to the presence of many other proteins that interfere with the... 

In recent years, there have been a tremendous research performed in the field of sestems containing small scales. However, besides all advantages of such systems, microfluidic systems have extraordinary difficulties and pumping liquid drops as part of some of these systems has been very important issue. An approach related to flow control is use of surface acoustic waves (SAW), which is known as acoustofluidic device. So far, most researches have only qualitatively investigated acoustic flux phenomenon. On the other hand, computational research is ongoing more emphasizing on accuracy, optimization, and obtaining more detailed physical understanding of SAW applications. Investigation of the...