Sharif Digital Repository

Folded protein experience several conformational substates. Each substate reperesents a minimum in the free energy surface of the system. Since Myoglobin is the smallest protein that can reversibly bind to gas molecules and, it can be used as prototype for more complex systems.IR pecrtum of CO inside of myolgobin shows that distinct conformational substates can occur. It was shown that Histidine residue inside heme pocket plays an essential rolle in structural properties of substates. In this study, we used molecular dynamice simulation together with umbrella sampling method to obtain free energy profile of MbCO system. The configuration of distal Histidine (His64), CO and Heme is studied... 

The Self-Consolidating (Compacting) Concrete (SCC) is a high performance concrete. Due to preventing it from segregation, SCC is known by its need to higher dosage of super plasticizer and viscose modifying agents. This increases the cost and reduces the popularity of SCC in construction industry. In this thesis, the production of Rice Husk Ash (RHA) from a controlled burning process using a special designed furnace, and cement replacement feasibility in the concrete mixture by low cost RHA, as an active pozzulanic additive have been investigated. Finding an appropriate ratio of replacement with cement for RHA and further effects on mechanical properties of SCC have been evaluated. The... 

Many petroleum engineering operations, such as drilling, well completions, and workover, may cause an alteration in the properties of hydrocarbon-bearing formations, including porosity and permeability. Solid and fluid influx into the reservoir in an overbalanced pressure condition can cause permeability reduction from formation damage in the invaded zone. While the solid invasion is limited to a few inches away from the wellbore, the fluids will invade significantly deeper into the formation. Therefore, the invasion of fluids may be considered as the primary mechanism that causes the near-wellbore damage. Correct quantification of the damage is an important component for predicting well... 

Corrosion study of the reinforced concrete is one of the most commonly investigation for the construction in civil engineering. The corrosion of embedded steel for the structures in the marine area like the Persian Gulf Sea Water needed considerable attentions. Presence of chlorides and decrease of pH in pores reinforcement depth of concrete is a serious problem. Research the corrosion rate in reinforced concrete system using fibers with a rebar is investigated. Cellulose and Carbon fiber materials are used as inhibitors. The addition of small quantities of these materials into the concrete mixture, will change the concrete permeability and the corrosion resistance rate. Tests demonstrate... 

The Reliability of substation structures with consideration of earthquake uncertainties is one of the most important subjects in structural analysis in recent years. In this project we first introduce IEEE-693-2005, which is the most effective and comprehensive seismic design code for electronic substations. Also in second chapter the rudimentary aspects of Reliability Theory and methods for evaluating the reliability of substation structures is introduced. Then with modeling the most common and most important electronic substation devices in Iran, with consideration of all seismic parameters and their uncertainties, the reliability of these structures evaluated. In this project for... 

This research deals with the problem of scheduling independent preemptive jobs on identical parallel machines, to minimize the total completion time (makespan). The transportation of an interrupted job from a machine to another machine requires considering a constant transportation delay i.e., Pm|prmp(delay)| Cmax. This delay is called transportation delay. We propose a Mixed Integer Linear Programming formulation for the research problem in case of two machines i.e., P2|prmp(delay)| Cmax. Since the research problem is shown to be NP-hard, a particle swarm optimization (PSO) algorithm is applied to solve the problem approximately. Based on the frequency of using local search procedure, three... 

Recently various speaker adaptation methods in HMM-based speech synthesis are proposed. The importance of adaptation techniques is that we can design a system in which speech is generated with high quality and target speaker characteristics through limited adaptation data sets.
In this research, we focus on adaptation based on clustering and develop a new and novel method using eigenvoices in order to adapt a new speaker. We employ this approach for the first time in HSMM-based speech synthesis systems and its goal is to reduce the parameters and adaptation data of the system. In our proposed method, first some speaker dependent models are trained. For each model we combine the... 

Today, computer simulations are employed prevalently by researchers to understand biological processes. The tendency to use computational methods has been increased recently due to the high costs and errors of experimental methods. Integrins are membrane proteins that mechanically attach cells to the extra cellular matrix (ECM) and derive some behaviors such as cell migration. Moreover, integrins have biochemical functions. They transduce environment signals and trigger chemical pathways. As a result, integrins regulate cell shape, motility, etc. The investigation of integrin behavior in a real environment is very difficult due to the presence of many other proteins that interfere with the... 

This thesis investigates nonlinear rolling of ships and effect of anti-rolling tanks. For this purpose numerical method is used. For studying this phenomenon, a program was developed in Simulink module of commercial software, MATLAB and roll motion has been simulated. The program has been developed so it can be used for displacement commercial vessels with a typical hull form and the simulated tank is a U-shape type tank. Simulation is 1-DOF and for rolling in regular waves with different encounter angel except for head sea and following sea. Results are included of roll degree, angular velocity and acceleration of ship and tanks fluid roll, encounter wave moment on ship and moment imposed... 

Using an efficient method to manage inventory systems is always a challenging issue in supply chain optimization. In supply chains including perishable goods, it is possible to reduce waste and other costs by identifying uncertain demand patterns and managing inventory levels at different stages of the supply chain. Considering the uncertainty and complex conditions of supply chains in the real world, in order to create a suitable model to express these conditions, various uncertain factors must be considered, each of which affects the supply chain inventory level in some way. In this research, a multi-level perishable supply chain model with uncertain demand, lead time and deterioration... 

One of the most simple questions of particle physics, which is still unanswered, is whether neutrino and antineutrino are the same particles or not. The answer to this question has many implications for the physics beyond the Standard Model, supersymmetric theories and unified theories.
In this thesis we first introduce Majorana fermion, the best candidate for which is neutrino. Then its implications for going beyond the standard Model have been discussed. At present time, the most important experiment which can prove this guess is neutrinoless double beta decay which has been studied in details in this thesis. The study of the theoretical and experimental aspects of neutrinoless double...