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An analytical model for prediction of controlled release from bulk biodegrading polymer microspheres
, Article Asian Journal of Pharmaceutical and Clinical Research ; Volume 11, Issue 3 , March , 2018 , Pages 432-437 ; 09742441 (ISSN) ; Sharif University of Technology
Innovare Academics Sciences Pvt. Ltd
2018
Abstract
Objective: a convenient numerical model has been developed to predict release profile of different types of agents from bulk biodegrading polymer microspheres, including magnitude methods are less accurate than analytical methods. Usually, this study used analytical solutions for the model and compared the analytical results with numerical solution and experimental data. Methods: The objective drug controlled release profiles were modeled based on a four-phase pattern. Then, a specific formulation was considered based on Fick’s second law. After calculating various parameters, the equations were solved using an analytical method. Results: Comparison results showed that analytical solution...
Design and fabrication of injectable microcarriers composed of acellular cartilage matrix and chitosan
, Article Journal of Biomaterials Science, Polymer Edition ; Volume 29, Issue 6 , 2018 , Pages 683-700 ; 09205063 (ISSN) ; Mashayekhan, S ; Sharif University of Technology
Taylor and Francis Inc
2018
Abstract
Cartilage is an avascular tissue with limited self-repair ability. Since the methods for treatment of cartilage defects have not been effective, new therapies based on tissue engineering are considered over the recent years. In this study, human cartilage tissue was decellularized and porous injectable microcarriers (MCs) composed of acellular extracellular matrix (ECM) of cartilage tissue and chitosan (CS), with different ECM weight ratios, were fabricated by electrospraying technique to be used in the treatment of articular cartilage defects. Various properties of ECM/CS MCs such as microstructure, mechanical strength, water uptake behaviour, and biodegradability rate were investigated....
Design and Fabrication of Scaffold Composed of Acellular Cartilage Matrix and Chitosan
, M.Sc. Thesis Sharif University of Technology ; Mashayekhan, Shohreh (Supervisor) ; Hasanzadeh, Zabihollah (Supervisor)
Abstract
Cartilage is an avascular tissue, having limited ability to repair itself. Since the methods for treatment of cartilage defects have been not effective, in recent years, new therapies based on tissue engineering are considered.This paper reports on the development of porous microcarriers composed of acellular matrix of cartilage and natural polymer chitosan. Microcarriers were prepared by electrospray method. Results of mechanical tests, SEM imaging, water uptake behaviour, biodegradation test, and MTT assay demonstrated that the microcarriers composed of 2% (wt) chitosan and 1% (wt) ECM has the best potential for growth and proliferation of primary chondrocyte cells. These results...
Radar Directional Finding by Interferometric Method in 2-18 GHzBW
, M.Sc. Thesis Sharif University of Technology ; Farzane, Frohar (Supervisor) ; Pezeshk, Amir Mansor (Co-Advisor)
Abstract
One of the important jobs of ESM and Elint receiver is to find the direction of arrival of the targets. Also DOA estimation has applications in guiding missiles and jammers location, position finding using of multiple DF systems which are placed in different locations is the most important use of this type of system.
A DF system has multiple parts: receiver, algorithm and arrays of antennas.
Amplitude comparison algorithms are more simple but on the other hand phase comparison algorithms prepare more accurate estimation. In this thesis these algorithms are simulated and to each other. And it will be concluded that, in the application being test, the "MUSIC" algorithm is the best....
A DF system has multiple parts: receiver, algorithm and arrays of antennas.
Amplitude comparison algorithms are more simple but on the other hand phase comparison algorithms prepare more accurate estimation. In this thesis these algorithms are simulated and to each other. And it will be concluded that, in the application being test, the "MUSIC" algorithm is the best....