Sharif Digital Repository

Nowadays, advanced and inexpensive pre-clinical methods for investigating the effects of anti-cancer drugs are expanding. One of the latest three-dimensional laboratory modeling for evaluating the effects of drugs is the use of tumor-on-chip technology, which actually models the physiological system of the body through three-dimensional scaffolds, multicellular cultures, and shaped vascular systems. In this study, three-dimensional culture of cancer cells was performed in the form of spheroids. A chip of U-shaped microstructures with and without gaps was used to trap cells and form cancer spheroids. We simulated the simultaneous effect of drug and oxygen concentration distribution inside the... 

Traditional classification techniques of machine learning assume that data have stationary distributions. This assumption for recent challenges where tremendous amount of data are generated at unprecedented rates with evolving patterns, is not true anymore. Classification of data streams has become an important area of machine learning, as the number of applications facing these challenges increases. Examples of such data streams applications include text streams, surveillance video streams, credit card fraud detection, market basket analysis, information filtering, computer security, etc. An appropriate method for such problems should adapt to drifting concepts by revising and refining the... 

Isn’t our universe ,which includes everything that is causally connected to us, a tiny and negligible part of wider and diverse “multiple universes”? Although the multiverse idea has been considered by scientists recently, it had been discussed by philosophers and theologians in the past.
Many of our physical theories,whether being accepted like General Relativity, or speculative like string theory, lead naturally to the multiverse idea .The idea of multiverse is also brought forth to take care of the fine tuning observed in cosmology, in connection with the so – called anthropic principle.
This idea appeared in order to answer to some problems of quantum mechanics, string theory... 

Duplex stainless steels and advanced high strength steels are both known as new materials in automobile industry applications. Process of resistance spot welding is the main process in welding of auto-body structures. Hence investigating the welding metallurgy and weldability of similar and dissimilar joints of duplex stainless steels and advanced high strength steel are crucial. The purpose of this study is to analyse the relationship between welding process and geometric characteristic of weld nugget, phase transformations of Weld nugget and heat affected zone, mechanical properties (i.e force bearing capacity and energy absorption capability) and failure mode (interfatial or pullout). in... 

Mixed-criticality embedded systems, as the next-generation of safety-critical systems, are increasingly employed in industry due to consolidating functionalities with varying criticality levels onto the same computing platform. Also, cost reduction and performance improvement encourage adoption of multicore platforms in these systems. Technology scaling, battery-supplied design and heavy computation in mixed-criticality systems necessitates employing energy management techniques. Due to the degrading effects of these techniques on the system’s reliability, reducing energy consumption without sacrificing the reliability requirement is a vital challenge in mixed-criticality systems, in... 

Passive wideband reconnaissance receivers, listen to the radio and radar signals in the environment and estimate their important parameters such as direction of arrival (DOA). The wideband attribute for these receivers is to refer to their ability to receive wideband signals.Due to the use of processing gain, LPI radars reduce their transmitted signal power to see and not to be seen. On the other hand reconnaissance receivers can not have much processing gain, because they do not know the nature of the transmitted signal; Therefore, to increase the operational range of these systems, it is necessary to increase the signal to noise power ratio (SNR). This thesis examines the use of antenna... 

We have reported a new and efficient synthesis of tetrahydrothiopyrano [2,3-b]indole skeletons via unique tandem reaction of indoline-2-thiones to Baylis-Hillman adduct acetates. This protocol is a very mild and simple method for construction heterocycles in a one-step process. This is a convenient and diastereoselective synthesis of methyl 4-aryl-2,3,4,9-tetrahydrothiopyrano[2,3-b]indole-3-carboxylate systems in the presence of K2CO3 in acetonitrile. The major benefits of the current study are the one-pot procedure, high yields and diastereoselectivity, short reaction times and the similarity of the products to the biologically active moieties.
In addition 1, 4-diazabicyclo [2.2.2]... 

About a century, “Eye Tracking” has been studied, and it has two definitions: • The process of measuring the point of gaze (where one is looking). • The process of measuring the motion of an eye relative to the head. Eye tracking technology has been used in many fields such as psychology. However, applications of this technology has been recently considered in marketing, computer interfacing, entertainment, training and so forth. Since pupil is a distinc area in eye images, pupil detection is one of the effective solutions of eye tracking. In most of the pupil detection approaches, the edge points of the pupil contour are detected firstly, and then the optimal ellipse is fitted to them.... 

Modeling and performance evaluation of the real time distributed systems is a significant problem. Stochastic activity network is one of the high level models used for this purpose. This network is an extension of generalized stochastic Petri net which is more powerful and flexible than other Petri net extensions. Checking the satisfiability of properties such as performance, dependability and user's expected properties is considerable in these models. Thus, using the approaches and generating modeling and model checking tools with the mentioned purpose is attractive. A model checker automatically checks the correctness of the system behaviors as properties against the model by getting the... 

This study has focused on the important problem of landing on a planet as an important current and future space mission. In this regard, dynamics modeling and integrated state estimation and control problems have been investigated in different views. To this aim, first a novel concurrent representation for translational and rotational kinematics has been developed based on the extension of modified Rodrigues parameters to dual space. This parameter set, called dual modified Rodrigues parameters (DMRP), is then utilized to establish an integrated roto-translational dynamic. The proposed DMRP-based kinematics and dynamics have been verified via comparison to traditional methods of... 

Prevalent deployment of Distributed Energy Resources(DERs) in the demand side of electrical energy grids has several advantages such as greenhouse gases emission reduction, mitigation of power losses in the distribution grids and abatement of the dependency on the wholesale generation companies. At the same time, it paves the way for the advent of local interactive energy trading frameworks. In the following thesis, a distributed data-driven algorithm is developed for market-clearing in a community-based local energy market. The social welfare maximization is considered as the objective of the energy trading. The production and demand of electricity are the decision variables of sellers and... 

Understanding biological systems requires extensive knowledge of individual parameters, and to study the processes of cell differentiation and cell behavior, a suitable environment must be created with the physiological conditions of the human body. For this purpose, with the knowledge of microfluidics, a microenvironment can be provided to study the behavior of cells on a small scale. The use of bone tissue model microfluidic chips is an alternative and new method in which it is possible to study the behavior of cells to differentiate into bone and to examine the toxicity of drugs, which in itself can help in the effective and successful treatment of these cases show. Therefore, in this... 

The main topic of this research is the navigation and control of a free-flying satellite with a robot manipulator while transferring and placing cargo on a space station. After connecting the cargo module, astronauts and robots need to deliver the available loads to the desired modules in a space station. Capturing an object or cargo is a critical issue studied extensively so far. However, delivery and placing of the cargo at the target point have not been investigated yet, to the best of the author’s knowledge; hence, this is a primary motivation for conducting the proposed research. After capturing the payload, the position and attitude of the manipulator with respect to the station’s...