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To Make the Membrane for Drug Retard Release by Supercritical System
, M.Sc. Thesis Sharif University of Technology ; Goodarznia, Iraj (Supervisor)
Abstract
In this study the main goal is to prepare a membrane to perform delayed drug release and absorbtion in the human body. To do so the supercritical method was used. A well-known biodegradable polymer was used. These kinds of polymers are used in drug delivery, wound dressing or scaffolding for cell culture. A membrane produced out of these kin of polymers is expected to have a good accordance with the goals.Ploy Vinyl alcohol, having very good bio degradable characteristics was used as the main polymer and Poly Ethylene Glycol (PEG) was used as an additive to make changes in the membrane structure. Also Dimethyl Sulfoxide, a polar solvent having the capability of solving both polymers is used....
Developing seedless growth of atomically thin semiconductor layers: Application to transition metal dichalcogenides
, Article Ceramics International ; Volume 44, Issue 13 , 2018 , Pages 15795-15803 ; 02728842 (ISSN) ; Sovizi, S ; Ghanbari, H ; Simchi, A ; Aboudzadeh, N ; Sharif University of Technology
Elsevier Ltd
2018
Abstract
Controlled growth of atomic monolayers of IV-VII transition metal dichalcogenides (TMDs) has provided unprecedented opportunities to fabricate modern optoelectronic nanodevices. However, synthesis of large-area and high quality two-dimensional TMDs is still challenging. We have synthesized WS2 and MoS2 nanosheets by atmospheric pressure chemical vapor deposition (APCVD) at wide-range of processing conditions. The nanostructures were analyzed by optical and confocal microscopy, atomic force microscopy, Raman spectroscopy, and X-ray diffraction to determine the thickness, lateral size and structure of the deposits. Through designing and performing of a set of controlled experiments as well as...
Experimental investigation of operating conditions for preparation of PVA-PEG blend membranes using supercritical CO2
, Article Journal of Supercritical Fluids ; Vol. 95 , November , 2014 , pp. 603-609 ; ISSN: 08968446 ; Nejad-Sadeghi, M ; Goodarznia, I ; Sharif University of Technology
2014
Abstract
Poly(vinyl alcohol)-polyethylene glycol, PVA-PEG, blended membrane were prepared using supercritical fluid assisted phase-inversion method, in which scCO2 was used as the anti-solvent. Poly(vinyl alcohol) was utilized as the main polymer, polyethylene glycol as the additive, and dimethyl sulfoxide (DMSO) as the solvent of these polymers. Taguchi method was used to investigate the effect of some operating parameters on the morphology of the membranes. The L16 orthogonal array was selected under the following conditions: pressure (100, 135, 165 and 200 bar), temperature (40, 45, 50 and 55°C) and PEG weight percent (0, 0.33, 0.66, and 1%). Total polymer concentration of solutions in all...
Nano drug-delivery systems for management of AIDS: liposomes, dendrimers, gold and silver nanoparticles
, Article Nanomedicine ; Volume 18, Issue 3 , 2023 , Pages 279-302 ; 17435889 (ISSN) ; Mousazadeh, M ; Taji, S ; Bahmani, A ; Khashayar, P ; Azimzadeh, M ; Mostafavi, E ; Sharif University of Technology
Newlands Press Ltd
2023
Abstract
AIDS causes increasing mortality every year. With advancements in nanomedicine, different nanomaterials (NMs) have been applied to treat AIDS and overcome its limitations. Among different NMs, nanoparticles (NPs) can act as nanocarriers due to their enhanced solubility, sustained release, targeting abilities and facilitation of drug-dose reductions. This review discusses recent advancements in therapeutics for AIDS/HIV using various NMs, mainly focused on three classifications: polymeric, liposomal and inorganic NMs. Polymeric dendrimers, polyethylenimine-NPs, poly(lactic-co-glycolic acid)-NPs, chitosan and the use of liposomal-based delivery systems and inorganic NPs, including gold and...
Hardware Implementation of Spiking Neural Networks
, M.Sc. Thesis Sharif University of Technology ; Shabany, Mahdi (Supervisor) ; Hashemi, Matin (Co-Supervisor)
Abstract
Spiking neural networks (SNNs) are third generation of neural networks. Similar to traditional neural networks, SNNs are comprised neurons. However, not only structure but also information processing is inspired by animal neural systems. SNNs can be called the most similar networks to animal neural systems. In such networks, the information is processed based on propagation of spike signals through the network. The type of data flow in these networks leads to being low-power when they are implemented on hardware. Therefore,there has been a upward trend in hardware implementation of them, like their FPGA implementations, for applications such as Big Data and Machine Learning. In this thesis,...
Gold nanorods for drug and gene delivery: An overview of recent advancements
, Article Pharmaceutics ; Volume 14, Issue 3 , 2022 ; 19994923 (ISSN) ; Mousazadeh, M ; Taji, S ; Bahmani, A ; Zarepour, A ; Zarrabi, A ; Sharifi, E ; Azimzadeh, M ; Sharif University of Technology
MDPI
2022
Abstract
Over the past few decades, gold nanomaterials have shown great promise in the field of nanotechnology, especially in medical and biological applications. They have become the most used nanomaterials in those fields due to their several advantageous. However, rod-shaped gold nanoparticles, or gold nanorods (GNRs), have some more unique physical, optical, and chemical properties, making them proper candidates for biomedical applications including drug/gene delivery, photothermal/photodynamic therapy, and theranostics. Most of their therapeutic applications are based on their ability for tunable heat generation upon exposure to near-infrared (NIR) radiation, which is helpful in both...
Synthesize and Characterization of 2D WS2 Nano-layers for Next Generation Optoelectronic Devices
, M.Sc. Thesis Sharif University of Technology ; Simchi, Abdolreza (Supervisor)
Abstract
Transition Metal Dichalcogenids (TMD) are types of 2D materials that exibit wide range of electronic, optical, mechanical, chemical, and thermal properties. These materials with MX2 general formula, have atract attentions with respect to their unusual properties because of their very limited dimensions. Their tunable properties and materials availibility make them attractive for wide range of applications. In recent years, chemical vapor deposition (CVD) methods are promising in preparing high quality TMD with scalable size, controllable thickness, and very excellent electronic properties. Also, chalenges are remaining in synthesis and transfering of TMD are difficulty for most of...
Seedless growth of two-dimensional disc-shaped WS2 layers by chemical vapor deposition
, Article Materials Chemistry and Physics ; Volume 257 , 2021 ; 02540584 (ISSN) ; Ghanbari, H ; Simchi, A ; Maghsoumi, A ; Sharif University of Technology
Elsevier Ltd
2021
Abstract
Chemical processing of two-dimensional (2D) transition metal dichalcogenides has attracted immense attention due to their unique optical, electrical, and catalytic properties. In this paper, we show that under special conditions during seedless chemical vapor deposition (CVD), it is possible to grow large-area 2D WS2 layers with disc-shaped morphology, which has been scarcely reported. Detailed characterizations of the CVD-grown layers by Raman spectroscopy, atomic force microscopy, transmission electron microscopy, and X-ray photoelectron spectroscopy have revealed that a gradient in the precursor concentration in the gas phase and strain energy in the deposited hexagonal clusters favor...
Physicomechanical properties of spark plasma sintered carbon nanotube-containing ceramic matrix nanocomposites
, Article Nanoscale ; Volume 9, Issue 35 , 2017 , Pages 12779-12820 ; 20403364 (ISSN) ; Sovizi, S ; Azarniya, A ; Rahmani Taji Boyuk, M. R ; Varol, T ; Nithyadharseni, P ; Madaah Hosseini, H. R ; Ramakrishna, S ; Reddy, M. V ; Sharif University of Technology
2017
Abstract
Recently, a wide variety of research works have focused on carbon nanotube (CNT)-ceramic matrix nanocomposites. In many cases, these novel materials are produced through conventional powder metallurgy methods including hot pressing, conventional sintering, and hot isostatic pressing. However, spark plasma sintering (SPS) as a novel and efficient consolidation technique is exploited for the full densification of high-temperature ceramic systems. In these binary nanocomposites, CNTs are added to ceramic matrices to noticeably modify their inferior properties and SPS is employed to produce fully dense compacts. In this review, a broad overview of these systems is provided and the potential...
Plasma Processing and Treatment of 2D Transition Metal Dichalcogenides: Tuning Properties and Defect Engineering
, Article Chemical Reviews ; Volume 123, Issue 24 , 2023 , Pages 13869-13951 ; 00092665 (ISSN) ; Angizi, S ; Ahmad Alem, A ; Goodarzi, R ; Rahmani Taji Boyuk, M. R ; Ghanbari, H ; Szoszkiewicz, R ; Simchi, A ; Kruse, P ; Sharif University of Technology
American Chemical Society
2023
Abstract
Two-dimensional transition metal dichalcogenides (TMDs) offer fascinating opportunities for fundamental nanoscale science and various technological applications. They are a promising platform for next generation optoelectronics and energy harvesting devices due to their exceptional characteristics at the nanoscale, such as tunable bandgap and strong light-matter interactions. The performance of TMD-based devices is mainly governed by the structure, composition, size, defects, and the state of their interfaces. Many properties of TMDs are influenced by the method of synthesis so numerous studies have focused on processing high-quality TMDs with controlled physicochemical properties....
Temperature-responsive smart nanocarriers for delivery of therapeutic agents: applications and recent advances
, Article ACS Applied Materials and Interfaces ; Volume 8, Issue 33 , 2016 , Pages 21107-21133 ; 19448244 (ISSN) ; Sahandi Zangabad, P ; Ghasemi, A ; Amiri, M ; Bahrami, M ; Malekzad, H ; Ghahramanzadeh Asl, H ; Mahdieh, Z ; Bozorgomid, M ; Ghasemi, A ; Rahmani Taji Boyuk, M. R ; Hamblin, M. R ; Sharif University of Technology
American Chemical Society
2016
Abstract
Smart drug delivery systems (DDSs) have attracted the attention of many scientists, as carriers that can be stimulated by changes in environmental parameters such as temperature, pH, light, electromagnetic fields, mechanical forces, etc. These smart nanocarriers can release their cargo on demand when their target is reached and the stimulus is applied. Using the techniques of nanotechnology, these nanocarriers can be tailored to be target-specific, and exhibit delayed or controlled release of drugs. Temperature-responsive nanocarriers are one of most important groups of smart nanoparticles (NPs) that have been investigated during the past decades. Temperature can either act as an external...
The relationship between an EFL teacher's gender and students' willingness to communicate
, Article International Journal of Communication and Linguistic Studies ; Volume 10, Issue 4 , 2013 , Pages 17-29 ; 23277882 (ISSN) ; Pakzadian, S. S
Common Ground Publishing
2013
Abstract
Learning a foreign language encompasses a process of trial and error that can lead to the progression of the learner's interlanguage, meaning that the learners make use of their language knowledge that receives feedback and brings about progress through diagnosis of the problems and being corrected by the teacher. Therefore, there exists a need to analyze the underlying reasons causing the students to remain taciturn with a low willingness to communicate (WTC) during a language class. There has been much work done investigating the role of the learner's stable personal characteristics (traits) along with their situational changes at a specific time (states) that influence the student's...
An automated simple algorithm for realistic pore network extraction from micro-tomography images
, Article Journal of Petroleum Science and Engineering ; Vol. 123, issue , 2014 , pp. 164-171 ; ISSN: 09204105 ; Jamshidi, S ; Salehi, S
2014
Abstract
Using 3-D scanned data to analyze and extract pore network plays a vital role in investigation of porous media's characteristics. In this paper, a new simple method is developed to detect pores and throats for analyzing the connectivity and permeability of the network. This automated method utilizes some of the common and well-known image processing functions which are widely accessible by researchers and this has led to an easy algorithm implementation. In this method, after polishing and quality control of images, using city-block distance function and watershed segmentation algorithm, pores and throats are detected and 3-D network is produced. This method can also be applied on 2-D images...
Discrimination of heart arrhythmias using novel features in heart rate phase space
, Article Computing in Cardiology ; Volume 40 , Sept , 2013 , Pages 1035-1038 ; 23258861 (ISSN); 9781479908844 (ISBN) ; Rezaei, S ; Salavatian, S
2013
Abstract
In this paper, we try to recognize and distinguish different groups of arrhythmia using novel features which have been obtained from the heart rate's phase space in recent years. For this purpose, we used Triangular Phase Space Mapping (TPSM) and Parabolic Phase Space Mapping (PPSM). For recognition, we used three groups of 15 subjects using the Physionet database (Arrhythmia, Congestive Heart Failure (CHF), and Atrial Fibrillation (AF)) with Normal Sinus Rhythm (NSR). The obtained features discriminate arrhythmia from NSR by p
An intelligent hybrid classification algorithm integrating fuzzy rule-based extraction and harmony search optimization: Medical diagnosis applications
, Article Knowledge-Based Systems ; Volume 220 , 2021 ; 09507051 (ISSN) ; Abdullah, S ; Akhavan Niaki, S. T ; Banihashemi, S ; Sharif University of Technology
Elsevier B.V
2021
Abstract
Uncertainty is a critical factor in medical datasets needed to be overcome for increasing diagnosis efficiency. This paper proposes an intelligent classification algorithm comprising a fuzzy rule-based approach, a harmony search (HS) algorithm, and a heuristic algorithm to classify medical datasets intelligently. Two fuzzy approaches, as well as orthogonal and triangular fuzzy sets, are first utilized to define the attributes of data. Then, an HS algorithm is integrated with a heuristic to generate fuzzy rules to select the best rules in the fuzzy rule-based systems. Moreover, to improve the performance of the proposed classification approach, a three-phase parameter tuning approach is...
Performance evaluation of shared hosting security methods
, Article Proc. of the 11th IEEE Int. Conference on Trust, Security and Privacy in Computing and Communications, TrustCom-2012 - 11th IEEE Int. Conference on Ubiquitous Computing and Communications ; 2012 , Pages 1310-1315 ; 9780769547459 (ISBN) ; Arshad, S ; Khoshkdahan, S ; Sharif University of Technology
2012
Abstract
Shared hosting is a kind of web hosting in which multiple websites reside on one webserver. It is cost-effective and makes the administration easier for websites' owners. However, shared hosting has some performance and security issues. In default shared hosting configuration, all websites' scripts are executed under the webserver's user account regardless of their owners. Therefore, a website is able to access other websites' resources. This security problem arises from lack of proper isolation between different websites hosted on the same webserver. In this survey, we have examined different methods for handling mentioned security issue. Also we evaluated the performance of mentioned...
The behaviour of an artificially cemented sandy gravel
, Article Geotechnical and Geological Engineering ; Volume 23, Issue 5 , 2005 , Pages 537-560 ; 09603182 (ISSN) ; Hosseini, S. M ; Toll, D. G ; Yasrebi, S. S ; Sharif University of Technology
2005
Abstract
The major section of the city of Tehran, Iran has been developed on cemented coarse-grained alluvium. This deposit consists of gravely sand to sandy gravel with some cobbles and is dominantly cemented by carbonaceous materials. In order to understand the mechanical behaviour of this soil, a series of undrained triaxial compression tests and unconfined compression tests were performed on uncemented and artificially cemented samples. Portland cement type I was used as the cementation agent for preparing artificially cemented samples. Uncemented samples and lightly cemented samples (1.5% cement) tested at high confining pressure showed contractive behaviour accompanied with positive excess pore...
An imperialist competitive algorithm approach for multi-objective optimization of direct coupling photovoltaic-electrolyzer systems
, Article International Journal of Hydrogen Energy ; Vol. 39, Issue 33 , 11 November , 2014 , pp. 18743-18757 ; ISSN: 03603199 ; Sayedin, F ; Khavas, S. S
2014
Abstract
In the context of sustainable clean hydrogen production pathways, photovoltaic-electrolyzer systems are one of the most promising alternatives for acquiring hydrogen from renewable energy sources. In fact, determining the optimal set of design and operating variables are always a key issue while coupling directly renewable electricity sources to PEM electrolyzers. Few previous studies have attempted to find the optimal size and operational condition of directly coupled photovoltaic-electrolyzer (PV/El) systems in order to maximize the hydrogen production or to minimize energy transfer loss between photovoltaic devices and the electrolyzer. Nevertheless an easy and efficient approach still...
Kalman filter based packet loss replacement in presence of additive noise
, Article 2012 25th IEEE Canadian Conference on Electrical and Computer Engineering: Vision for a Greener Future, CCECE 2012 ; 2012 ; 9781467314336 (ISBN) ; Ghorshi, S ; Tahaei, A
2012
Abstract
A major problem in real-time packet-based communication systems, is misrouted or delayed packets which results in degraded perceived voice quality. If packets are not available on time, the packets are considered as lost. The easiest solution in a network terminal receiver is to replace silence for the duration of lost speech segments. In a high quality communication system, to avoid degradation in speech quality due to packet loss, a suitable method or algorithm is needed to replace the missing segments of speech. In this paper, we introduce an adaptive filter for replacement of lost speech segment. In this method Kalman filter as a state-space based method will be used to predict the...
Investigation of Mesh Sensitivity Influence to Determine Crack Characteristic by Finite Element Methods
, Article Journal of Failure Analysis and Prevention ; Volume 16, Issue 3 , 2016 , Pages 506-512 ; 15477029 (ISSN) ; Mirjavadi, S. S ; Asli, S. A ; Sharif University of Technology
Springer New York LLC
2016
Abstract
In this research, an extended finite element model has been investigated. Investigation of opening and closure stress always has been one of the difficult parameters to analysis of results; therefore, the utilization of finite element methods would be a good and logical alternative for this purpose. In addition, linear elastic fracture criteria are used for validation of numerical results from the simulation. In this work, a detailed analysis of the influence of different parameters in the results of a specific specimen with a semi-elliptical tooling groove in terms of closure and opening stress is presented, and the impact of optimum element size in fracture characteristic in various load...